Biventricular Impairment and Ventricular Interdependence in Patients With Alcoholic Cardiomyopathy: Insights Through Cardiac Magnetic Resonance Imaging

• Published in: Journal of magnetic resonance imaging Vol. 61; no. 1; pp. 289 - 302
• Main Authors: Wang, Jin, Yang, Zhi‐Gang, Fang, Han, Yan, Wei‐Feng, Shen, Meng‐Ting, Guo, Ying‐Kun, Jiang, Li, Jiang, Yu, Min, Chen‐Yan, Li, Yuan
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.01.2025; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; alcoholic cardiomyopathy; Cardiomyopathy; Cardiomyopathy, Alcoholic - diagnostic imaging; Case-Control Studies; Congestive heart failure; Contrast Media; Echo-Planar Imaging; Female; Field strength; Gadolinium; Heart diseases; Heart Ventricles - diagnostic imaging; Heart Ventricles - physiopathology; Humans; Impairment; late gadolinium enhancement; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Medical imaging; Microvasculature; Middle Aged; Multivariable control; Perfusion; Population studies; Recovery; Regression analysis; Regression models; Retrospective Studies; Statistical analysis; Statistical tests; strain; Strain rate; Structure-function relationships; Ventricle; ventricular interdependence; strain; alcoholic cardiomyopathy; magnetic resonance imaging; perfusion; late gadolinium enhancement; ventricular interdependence
• DOI: 10.1002/jmri.29350
• ISSN: 1053-1807; 1522-2586

Background Alcoholic cardiomyopathy (ACM) can lead to progressive cardiac dysfunction and heart failure, but little is known about biventricular impairment and ventricular interdependence (VI) in ACM patients. Purpose To use cardiac MRI to investigate biventricular impairment and VI in ACM patients. Study Type Retrospective. Population Forty‐one male patients with ACM and 45 sex‐ and age‐matched controls. Field Strength/Sequence 3.0 T/balanced steady‐state free precession sequence, inversion recovery prepared echo‐planar imaging sequence and phase‐sensitive inversion recovery sequence. Assessment Biventricular structure, function, and global strain (encompassing peak strain [PS], peak systolic, and diastolic strain rate), PS of interventricular septal (IVS), microvascular perfusion (including upslope and time to maximum signal intensity [TTM]), late gadolinium enhancement (LGE), and baseline characteristics were compared between the controls and ACM patients. Statistical Tests Student's t‐test, Mann–Whitney U test, Pearson's correlation, and multivariable linear regression models with a stepwise selection procedure. A two‐tailed P value <0.05 was deemed as statistically significant. Results Compared to control subjects, ACM patients showed significantly biventricular adverse remodeling, reduced left ventricle (LV) global upslope and prolonged global TTM, and the presence of LGE. ACM patients were characterized by a significant decline in all global strain within the LV, right ventricle (RV), and IVS compared with the controls. RV global PS was significantly associated with LV global PS and IVS PS in radial, circumferential, and longitudinal directions. Multivariable analyses demonstrated the longitudinal PS of IVS was significantly correlated with RV global radial PS (β = 0.614) and circumferential PS (β = 0.545). Additionally, RV global longitudinal PS (GLPS) was significantly associated with radial PS of IVS (β = −0.631) and LV GLPS (β = 1.096). Data Conclusion ACM patients exhibited biventricular adverse structural alterations and impaired systolic and diastolic function. This cohort also showed reduced LV microvascular perfusion, the presence of LGE, and unfavorable VI. Evidence Level 3 Technical Efficacy Stage 3