The Discovery of Phenylbenzamide Derivatives as Grb7-Based Antitumor Agents

• Published in: ChemMedChem Vol. 8; no. 2; pp. 280 - 288
• Main Authors: Ambaye, Nigus D., Gunzburg, Menachem J., Lim, Reece C. C., Price, John T., Wilce, Matthew C. J., Wilce, Jacqueline A.
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.02.2013; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Subjects: Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Benzamides - chemistry; Benzamides - pharmacology; Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - metabolism; Calorimetry; Cell Line, Tumor; Cell Proliferation - drug effects; Female; Grb7; GRB7 Adaptor Protein - antagonists & inhibitors; GRB7 Adaptor Protein - chemistry; GRB7 Adaptor Protein - metabolism; Humans; Medical research; Molecular Docking Simulation; phenylbenzamides; SH2 domain; src Homology Domains - drug effects; virtual screening

Grb7 is a non‐catalytic protein, the overexpression of which has been associated with the proliferative and migratory potentials of cancer cells. Virtual screening strategies involving a shape‐based similarity search, molecular docking, and 2D‐similarity searches complemented by experimental binding...