Induction of cell apoptosis in 3T3-L1 pre-adipocytes by flavonoids is associated with their antioxidant activity

Obesity is biologically characterized at the cellular level by an increase in the number and size of adipocytes differentiated from fibroblastic pre‐adipocytes in adipose tissue. In this study, we focused on the relationship between the influence of flavonoids on cell population growth and their ant...

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Published inMolecular nutrition & food research Vol. 50; no. 11; pp. 1072 - 1079
Main Authors Hsu, Chin-Lin, Yen, Gow-Chin
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.11.2006
WILEY‐VCH Verlag
Wiley-VCH-Verl
Subjects
3T3-L1 Cells
Adipocytes - cytology
Adipocytes - drug effects
Animals
Antioxidant
Antioxidants - pharmacology
Apoptosis
Apoptosis - drug effects
Biological and medical sciences
Cell Division - drug effects
Flavonoids
Flavonoids - pharmacology
Food industries
Fundamental and applied biological sciences. Psychology
L-Lactate Dehydrogenase - metabolism
Membrane Potential, Mitochondrial - drug effects
Mice
Pre-adipocytes
Quercetin
Quercetin - pharmacology
Reactive Oxygen Species
Spectrometry, Fluorescence
Adipocyte
Polyphenol
Induction
Quercetin
Antioxidant
ptosis / Flavonoids / Pre-adipocytes / Quercetin
Flavonoid
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Abstract Obesity is biologically characterized at the cellular level by an increase in the number and size of adipocytes differentiated from fibroblastic pre‐adipocytes in adipose tissue. In this study, we focused on the relationship between the influence of flavonoids on cell population growth and their antioxidant activity. The results showed that the inhibition of flavonoids (naringenin, rutin, hesperidin, resveratrol, naringin and quercetin) on 3T3‐L1 pre‐adipocytes was 28.3, 8.1, 11.1, 33.2, 5.6 and 71.5%, respectively. In oxygen radical absorbance capacity (ORAC) assay, quercetin had the highest ORACROO value among the six flavonoids tested. Apoptosis assays showed that quercetin increased apoptotic cells in time‐ and dose‐dependent manner. Treatment of cells with quercetin decreased the mitochondrial membrane potential in the courses of time and dose. The cell apoptosis/necrosis assay showed that quercetin increased the number of apoptotic cells, but not necrotic cells. Quercetin treatment of cells caused a significant time‐ and dose‐dependent increase in the caspase‐3 activity. Western analysis indicated that treatment of quercetin markedly down‐regulated PARP and Bcl‐2 proteins, and activated caspase‐3, Bax, and Bak proteins. These results indicate that quercetin efficiently inhibits cell population growth and induction of apoptosis in 3T3‐L1 pre‐adipocytes.
AbstractList Obesity is biologically characterized at the cellular level by an increase in the number and size of adipocytes differentiated from fibroblastic pre‐adipocytes in adipose tissue. In this study, we focused on the relationship between the influence of flavonoids on cell population growth and their antioxidant activity. The results showed that the inhibition of flavonoids (naringenin, rutin, hesperidin, resveratrol, naringin and quercetin) on 3T3‐L1 pre‐adipocytes was 28.3, 8.1, 11.1, 33.2, 5.6 and 71.5%, respectively. In oxygen radical absorbance capacity (ORAC) assay, quercetin had the highest ORACROO value among the six flavonoids tested. Apoptosis assays showed that quercetin increased apoptotic cells in time‐ and dose‐dependent manner. Treatment of cells with quercetin decreased the mitochondrial membrane potential in the courses of time and dose. The cell apoptosis/necrosis assay showed that quercetin increased the number of apoptotic cells, but not necrotic cells. Quercetin treatment of cells caused a significant time‐ and dose‐dependent increase in the caspase‐3 activity. Western analysis indicated that treatment of quercetin markedly down‐regulated PARP and Bcl‐2 proteins, and activated caspase‐3, Bax, and Bak proteins. These results indicate that quercetin efficiently inhibits cell population growth and induction of apoptosis in 3T3‐L1 pre‐adipocytes.
Obesity is biologically characterized at the cellular level by an increase in the number and size of adipocytes differentiated from fibroblastic pre-adipocytes in adipose tissue. In this study, we focused on the relationship between the influence of flavonoids on cell population growth and their antioxidant activity. The results showed that the inhibition of flavonoids (naringenin, rutin, hesperidin, resveratrol, naringin and quercetin) on 3T3-L1 pre-adipocytes was 28.3, 8.1, 11.1, 33.2, 5.6 and 71.5%, respectively. In oxygen radical absorbance capacity (ORAC) assay, quercetin had the highest ORAC(ROO) value among the six flavonoids tested. Apoptosis assays showed that quercetin increased apoptotic cells in time- and dose-dependent manner. Treatment of cells with quercetin decreased the mitochondrial membrane potential in the courses of time and dose. The cell apoptosis/necrosis assay showed that quercetin increased the number of apoptotic cells, but not necrotic cells. Quercetin treatment of cells caused a significant time- and dose-dependent increase in the caspase-3 activity. Western analysis indicated that treatment of quercetin markedly down-regulated PARP and Bcl-2 proteins, and activated caspase-3, Bax, and Bak proteins. These results indicate that quercetin efficiently inhibits cell population growth and induction of apoptosis in 3T3-L1 pre-adipocytes.Obesity is biologically characterized at the cellular level by an increase in the number and size of adipocytes differentiated from fibroblastic pre-adipocytes in adipose tissue. In this study, we focused on the relationship between the influence of flavonoids on cell population growth and their antioxidant activity. The results showed that the inhibition of flavonoids (naringenin, rutin, hesperidin, resveratrol, naringin and quercetin) on 3T3-L1 pre-adipocytes was 28.3, 8.1, 11.1, 33.2, 5.6 and 71.5%, respectively. In oxygen radical absorbance capacity (ORAC) assay, quercetin had the highest ORAC(ROO) value among the six flavonoids tested. Apoptosis assays showed that quercetin increased apoptotic cells in time- and dose-dependent manner. Treatment of cells with quercetin decreased the mitochondrial membrane potential in the courses of time and dose. The cell apoptosis/necrosis assay showed that quercetin increased the number of apoptotic cells, but not necrotic cells. Quercetin treatment of cells caused a significant time- and dose-dependent increase in the caspase-3 activity. Western analysis indicated that treatment of quercetin markedly down-regulated PARP and Bcl-2 proteins, and activated caspase-3, Bax, and Bak proteins. These results indicate that quercetin efficiently inhibits cell population growth and induction of apoptosis in 3T3-L1 pre-adipocytes.
Obesity is biologically characterized at the cellular level by an increase in the number and size of adipocytes differentiated from fibroblastic pre-adipocytes in adipose tissue. In this study, we focused on the relationship between the influence of flavonoids on cell population growth and their antioxidant activity. The results showed that the inhibition of flavonoids (naringenin, rutin, hesperidin, resveratrol, naringin and quercetin) on 3T3-L1 pre-adipocytes was 28.3, 8.1, 11.1, 33.2, 5.6 and 71.5%, respectively. In oxygen radical absorbance capacity (ORAC) assay, quercetin had the highest ORAC(ROO) value among the six flavonoids tested. Apoptosis assays showed that quercetin increased apoptotic cells in time- and dose-dependent manner. Treatment of cells with quercetin decreased the mitochondrial membrane potential in the courses of time and dose. The cell apoptosis/necrosis assay showed that quercetin increased the number of apoptotic cells, but not necrotic cells. Quercetin treatment of cells caused a significant time- and dose-dependent increase in the caspase-3 activity. Western analysis indicated that treatment of quercetin markedly down-regulated PARP and Bcl-2 proteins, and activated caspase-3, Bax, and Bak proteins. These results indicate that quercetin efficiently inhibits cell population growth and induction of apoptosis in 3T3-L1 pre-adipocytes.
Obesity is biologically characterized at the cellular level by an increase in the number and size of adipocytes differentiated from fibroblastic pre‐adipocytes in adipose tissue. In this study, we focused on the relationship between the influence of flavonoids on cell population growth and their antioxidant activity. The results showed that the inhibition of flavonoids (naringenin, rutin, hesperidin, resveratrol, naringin and quercetin) on 3T3‐L1 pre‐adipocytes was 28.3, 8.1, 11.1, 33.2, 5.6 and 71.5%, respectively. In oxygen radical absorbance capacity (ORAC) assay, quercetin had the highest ORAC ROO value among the six flavonoids tested. Apoptosis assays showed that quercetin increased apoptotic cells in time‐ and dose‐dependent manner. Treatment of cells with quercetin decreased the mitochondrial membrane potential in the courses of time and dose. The cell apoptosis/necrosis assay showed that quercetin increased the number of apoptotic cells, but not necrotic cells. Quercetin treatment of cells caused a significant time‐ and dose‐dependent increase in the caspase‐3 activity. Western analysis indicated that treatment of quercetin markedly down‐regulated PARP and Bcl‐2 proteins, and activated caspase‐3, Bax, and Bak proteins. These results indicate that quercetin efficiently inhibits cell population growth and induction of apoptosis in 3T3‐L1 pre‐adipocytes.
Author Yen, Gow-Chin
Hsu, Chin-Lin
Author_xml – sequence: 1
  givenname: Chin-Lin
  surname: Hsu
  fullname: Hsu, Chin-Lin
  organization: Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan. Fax: +886-4-2285-4378
– sequence: 2
  givenname: Gow-Chin
  surname: Yen
  fullname: Yen, Gow-Chin
  email: gcyen@nchu.edu.tw
  organization: E-mail: gcyen@nchu.edu.tw
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Keywords Adipocyte
Polyphenol
Induction
Quercetin
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ptosis / Flavonoids / Pre-adipocytes / Quercetin
Flavonoid
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PublicationDate_xml – month: 11
  year: 2006
  text: November 2006
PublicationDecade 2000
PublicationPlace Weinheim
PublicationPlace_xml – name: Weinheim
– name: Germany
PublicationTitle Molecular nutrition & food research
PublicationTitleAlternate Mol. Nutr. Food Res
PublicationYear 2006
Publisher WILEY-VCH Verlag
WILEY‐VCH Verlag
Wiley-VCH-Verl
Publisher_xml – name: WILEY-VCH Verlag
– name: WILEY‐VCH Verlag
– name: Wiley-VCH-Verl
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Snippet Obesity is biologically characterized at the cellular level by an increase in the number and size of adipocytes differentiated from fibroblastic pre‐adipocytes...
Obesity is biologically characterized at the cellular level by an increase in the number and size of adipocytes differentiated from fibroblastic pre-adipocytes...
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SubjectTerms 3T3-L1 Cells
Adipocytes - cytology
Adipocytes - drug effects
Animals
Antioxidant
Antioxidants - pharmacology
Apoptosis
Apoptosis - drug effects
Biological and medical sciences
Cell Division - drug effects
Flavonoids
Flavonoids - pharmacology
Food industries
Fundamental and applied biological sciences. Psychology
L-Lactate Dehydrogenase - metabolism
Membrane Potential, Mitochondrial - drug effects
Mice
Pre-adipocytes
Quercetin
Quercetin - pharmacology
Reactive Oxygen Species
Spectrometry, Fluorescence
Title Induction of cell apoptosis in 3T3-L1 pre-adipocytes by flavonoids is associated with their antioxidant activity
URI https://api.istex.fr/ark:/67375/WNG-8CTPSLCJ-0/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fmnfr.200600040
https://www.ncbi.nlm.nih.gov/pubmed/17039455
https://www.proquest.com/docview/68124079
Volume 50
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