Development of a Generic Physiologically-Based Pharmacokinetic Model for Lactation and Prediction of Maternal and Infant Exposure to Ondansetron via Breast Milk

• Published in: Clinical pharmacology and therapeutics Vol. 111; no. 5; p. 1111
• Main Authors: Job, Kathleen M, Dallmann, André, Parry, Samuel, Saade, George, Haas, David M, Hughes, Brenna, Berens, Pamela, Chen, Jia-Yu, Fu, Christina, Humphrey, Kelsey, Hornik, Christoph, Balevic, Stephen, Zimmerman, Kanecia, Watt, Kevin
• Format: Journal Article
• Language: English
• Published: United States 01.05.2022
• Subjects: Breast Feeding; Female; Humans; Infant; Lactation; Milk, Human; Ondansetron - adverse effects; Postpartum Period

Ondansetron is commonly used in breastfeeding mothers to treat nausea and vomiting. There is limited information in humans regarding safety of ondansetron exposure to nursing infants and no adequate study looking at ondansetron pharmacokinetics during lactation. We developed a generic physiologicall...