Targeting of the circadian clock via CK1δ/ε to improve glucose homeostasis in obesity

• Published in: Scientific reports Vol. 6; no. 1; p. 29983
• Main Authors: Cunningham, Peter S., Ahern, Siobhán A., Smith, Laura C., da Silva Santos, Carla S., Wager, Travis T., Bechtold, David A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.07.2016; Nature Publishing Group
• Subjects: 59/5; 631/378/1385/1330; 631/443/319/1557; 631/443/319/1642/393; 64/60; 96/106; Adipose Tissue, White - metabolism; Adipose Tissue, White - pathology; Animals; Behavior, Animal; Casein Kinase Idelta - metabolism; Casein Kinase Iepsilon - metabolism; Circadian Clocks - genetics; Circadian Rhythm; CLOCK Proteins - genetics; CLOCK Proteins - metabolism; Diet, High-Fat; Gene Expression Regulation; Glucose - metabolism; Gonads - metabolism; Homeostasis; Humanities and Social Sciences; Hypothalamus - metabolism; Inflammation - pathology; Male; Mice, Inbred C57BL; Mice, Obese; multidisciplinary; Obesity - metabolism; Organ Specificity - genetics; PPAR alpha - metabolism; Science

Growing evidence indicates that disruption of our internal timing system contributes to the incidence and severity of metabolic diseases, including obesity and type 2 diabetes. This is perhaps not surprising since components of the circadian clockwork are tightly coupled to metabolic processes acros...