Drug sensitivity and isoenzyme type in cloned lines of Plasmodium falciparum

Plasmodium falciparum clones (derived by limiting dilution from recent isolates from Africa and Brazil) characterized for pyrimethamine and chloroquine sensitivity and/or isoenzyme type, different levels of drug sensitivity among clones

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Bibliographic Details
Published inThe American journal of tropical medicine and hygiene Vol. 33; no. 2; pp. 212 - 219
Main Authors Graves, P.M, Carter, R, Keystone, J.S, Seeley, D.C., jr
Format Journal Article
LanguageEnglish
Published United States 01.03.1984
Subjects
Africa
Animals
Brazil
Chloroquine - pharmacology
Clone Cells - drug effects
Clone Cells - enzymology
clones
Dose-Response Relationship, Drug
drug resistance
Drug Resistance, Microbial
enzymes
genetics
Glucose-6-Phosphate Isomerase - classification
Isoenzymes - classification
Plasmodium falciparum
Plasmodium falciparum - drug effects
Plasmodium falciparum - enzymology
Protozoa
Pyrimethamine - pharmacology
Treatment and control
variation
Brazil
Africa
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Abstract Plasmodium falciparum clones (derived by limiting dilution from recent isolates from Africa and Brazil) characterized for pyrimethamine and chloroquine sensitivity and/or isoenzyme type, different levels of drug sensitivity among clones
AbstractList Clones have been derived by limiting dilution from recent isolates of Plasmodium falciparum from Africa and Brazil. These clones have been characterized for pyrimethamine and chloroquine sensitivity and/or isoenzyme type. Clones obtained from an isolate containing a mixture of GPI isoenzyme types were found to have (with one exception) only GPI-1 or GPI-2. Clones differing 1,000-fold in pyrimethamine resistance were derived from a single isolate from Brazil which was resistant to both pyrimethamine and chloroquine. Several levels of chloroquine sensitivity were observed in the isolates studied. All clones showed levels of chloroquine sensitivity similar to that of their parent isolates. The KZ1 isolate from East Africa had an intermediate level of chloroquine resistance and a flat dose-response curve and each of its clones had a similar dose-response curve, indicating that the intermediate level of chloroquine resistance did not result from the KZ1 isolate's being a mixture of clones with high and low sensitivity.
Plasmodium falciparum clones (derived by limiting dilution from recent isolates from Africa and Brazil) characterized for pyrimethamine and chloroquine sensitivity and/or isoenzyme type, different levels of drug sensitivity among clones
Author Keystone, J.S
Graves, P.M
Seeley, D.C., jr
Carter, R
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/6370002$$D View this record in MEDLINE/PubMed
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Snippet Plasmodium falciparum clones (derived by limiting dilution from recent isolates from Africa and Brazil) characterized for pyrimethamine and chloroquine...
Clones have been derived by limiting dilution from recent isolates of Plasmodium falciparum from Africa and Brazil. These clones have been characterized for...
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SubjectTerms Africa
Animals
Brazil
Chloroquine - pharmacology
Clone Cells - drug effects
Clone Cells - enzymology
clones
Dose-Response Relationship, Drug
drug resistance
Drug Resistance, Microbial
enzymes
genetics
Glucose-6-Phosphate Isomerase - classification
Isoenzymes - classification
Plasmodium falciparum
Plasmodium falciparum - drug effects
Plasmodium falciparum - enzymology
Protozoa
Pyrimethamine - pharmacology
Treatment and control
variation
Title Drug sensitivity and isoenzyme type in cloned lines of Plasmodium falciparum
URI https://www.ncbi.nlm.nih.gov/pubmed/6370002
Volume 33
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