Discovery of a non-cationic cell penetrating peptide derived from membrane-interacting human proteins and its potential as a protein delivery carrier

• Published in: Scientific reports Vol. 5; no. 1; p. 11719
• Main Authors: Young Kim, Hyo, Young Yum, Soo, Jang, Goo, Ahn, Dae-Ro
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.06.2015; Nature Publishing Group
• Subjects: 631/61/2297; 631/61/2298; 631/92/152; 631/92/611; Amino Acid Sequence; Animals; Annexins - chemistry; beta-Galactosidase - metabolism; Cations; Cell Membrane - metabolism; Cell-Penetrating Peptides - chemistry; Cell-Penetrating Peptides - pharmacology; Circular Dichroism; Drug Carriers; Drug Delivery Systems; Drug Design; Endocytosis - drug effects; HeLa Cells; Humanities and Social Sciences; Humans; Intracellular Space - metabolism; Membrane Proteins - chemistry; Mice; Molecular Sequence Data; multidisciplinary; Protein Conformation; Protein Isoforms - metabolism; Protein Stability; Protein Transport; RAW 264.7 Cells; Science; Subcellular Fractions - metabolism

Cell penetrating peptides (CPPs) are peptides that can be translocated into cells and used as a carrier platform for the intracellular uptake of cargo molecules. Subject to the source of CPP sequences and their positively charged nature, the cytotoxicity and immunogenicity of conventional CPPs needs...