Noradrenergic Regulation of Cognitive Flexibility: No Effects of Stress, Transcutaneous Vagus Nerve Stimulation, and Atomoxetine on Task-switching in Humans

• Published in: Journal of cognitive neuroscience Vol. 32; no. 10; pp. 1881 - 1895
• Main Authors: Tona, Klodiana-Daphne, Revers, Hans, Verkuil, Bart, Nieuwenhuis, Sander
• Format: Journal Article
• Language: English
• Published: One Rogers Street, Cambridge, MA 02142-1209, USA MIT Press 01.10.2020; MIT Press Journals, The
• Subjects: Atomoxetine Hydrochloride; Bayes Theorem; Bayesian analysis; Between-subjects design; Cognition; Cognitive ability; Cross-Over Studies; Cues; Double-Blind Method; Flexibility; Humans; Neuromodulation; Norepinephrine; Reaction Time; Vagus nerve; Vagus Nerve Stimulation

Cognitive flexibility allows us to adaptively switch between different responsibilities in important domains of our daily life. Previous work has elucidated the neurochemical basis underlying the ability to switch responses to a previously nonreinforced exemplar and to switch between attentional set...