Targeted screening of an anti-inflammatory polypeptide from Rhopilema esculentum Kishinouye cnidoblasts and elucidation of its mechanism in alleviating ulcerative colitis based on an analysis of the gut microbiota and metabolites

• Published in: Food science and human wellness Vol. 13; no. 3; pp. 1336 - 1347
• Main Authors: Wang, Ziyan, Shi, Qiuyue, Feng, Ying, Han, Jiaojiao, Lu, Chenyang, Zhou, Jun, Wang, Zhonghua, Su, Xiurong
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.05.2024; Key Laboratory of Aquaculture Biotechnology(Ningbo University),Ministry of Education,Ningbo University,Ningbo 315000,China%College of Life Sciences,Tonghua Normal University,Tonghua 134000,China%Shandong Beiyou Biotechnology Co.,Ltd.,Weifang 261000,China; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products,Ningbo University,Ningbo 315000,China; School of Marine Science,Ningbo University,Ningbo 315000,China; Tsinghua University Press
• Subjects: arachidonic acid; blood serum; Cnidoblasts; digestive system; food science; glycerophospholipids; humans; intestinal microorganisms; ligands; linoleic acid; Marine bioactive polypeptides; metabolism; metabolites; metabolome; Metagenome; metagenomics; necrosis; neoplasms; polypeptides; protective effect; Rhopilema esculentum Kishinouye; Serum metabolome; Ulcerative colitis; Marine bioactive polypeptides; Rhopilema esculentum Kishinouye; Cnidoblasts; Serum metabolome; Metagenome; Ulcerative colitis

Ulcerative colitis (UC) is a recurrent inflammatory bowel disease that imposes a severe burden on families and society. In recent years, exploiting the potential of marine bioactive peptides for the treatment of diseases has become a topic of intense research interest. This study revealed the mechan...