Inhibition of Serum- and Calcium-Induced Differentiation of Human Keratinocytes by HPV16 E6 Oncoprotein: Role of p53 Inactivation

• Published in: Virology (New York, N.Y.) Vol. 237; no. 2; pp. 296 - 306
• Main Authors: Sherman, Levana, Jackman, Anna, Itzhaki, Hagar, Stöppler, Melissa Conrad, Koval, Debbie, Schlegel, Richard
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 27.10.1997
• Subjects: Blood Proteins - pharmacology; Calcium - pharmacology; Cell Differentiation - drug effects; Cells, Cultured; Gene Expression Regulation, Viral; Humans; Keratinocytes - cytology; Keratinocytes - physiology; Keratinocytes - virology; Oncogene Proteins, Viral - genetics; Repressor Proteins; Transfection; Tumor Suppressor Protein p53 - genetics

We have recently shown that human papillomavirus (HPV16) E6 oncoprotein exhibits two separate biological activities in genital keratinocytes (PHKs). E6 protein by itself is capable of inducing colonies of proliferating cells resistant to serum and calcium-induced differentiation, whereas both E6 and...