6β-Hydroxycortisol Is an Endogenous Probe for Evaluation of Drug–Drug Interactions Involving a Multispecific Renal Organic Anion Transporter, OAT3/SLC22A8, in Healthy Subjects - Imamura, Yuichiro; Tsuruya, Yuri; Damme, Katja; Heer, Dominik; Kumagai, Yuji; Maeda, Kazuya; Murayama, Nobuyuki; Okudaira, Noriko; Kurihara, Atsushi; Izumi, Takashi; Sugiyama, Yuichi; Kusuhara, Hiroyuki (Drug metabolism and disposition, 2014)
Keywords: Adult; Animals; Biomarkers - blood; Biomarkers - urine; Cell Culture Techniques; Drug Interactions; Female; Healthy Volunteers; HEK293 Cells; Humans; Hydrocortisone - analogs & derivatives; Hydrocortisone - blood; Hydrocortisone - urine; Kidney - drug effects; Kidney - metabolism; Male; Metabolic Clearance Rate; Mice; Mice, Knockout; Organic Anion Transporters, Sodium-Independent - genetics; Organic Anion Transporters, Sodium-Independent - metabolism; Organic Cation Transport Proteins - genetics; Organic Cation Transport Proteins - metabolism; Pharmaceutical Preparations - metabolism; Substrate Specificity; Young Adult; CLrenal sec; OCT; OAT; CLtot; AUCcortisol; MATE; X6β-OHF; DDI; 11β-HSD; hOAT; MPP; AUC; HEK; LC-MS/MS; 6β-OHF; CL6β-OHF; DX-619; AUC6β-OHF; CLrenal; PO