In Vitro and In Vivo Characterization of 13 CYP2C9 Allelic Variants Found in Chinese Han Population

• Published in: Drug metabolism and disposition Vol. 43; no. 4; pp. 561 - 569
• Main Authors: Hu, Guo-Xin, Pan, Pei-Pei, Wang, Zeng-Shou, Yang, Li-Ping, Dai, Da-Peng, Wang, Shuang-Hu, Zhu, Guang-Hui, Qiu, Xiang-Jun, Xu, Tao, Luo, Jun, Lian, Qing-Quan, Ge, Ren-Shan, Cai, Jian-Ping
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2015
• Subjects: Alleles; Animals; Area Under Curve; Asian People - genetics; Chlorocebus aethiops; Chromatography, High Pressure Liquid; COS Cells; Cytochrome P-450 CYP2C9 - genetics; Gene Frequency - genetics; Genetic Variation; Genetics, Population; Genotype; Humans; Plasmids; Tolbutamide - blood; Tolbutamide - urine; Transfection; ORF; ADME; t1/2; CYP; PCR; AUC; CL/F

Our previous study detected totally 35 CYP2C9 allelic variants in 2127 Chinese subjects, of whom 21 novel alleles were reported for the first time in Chinese populations. The aim of the present study was to characterize the 13 CYP2C9 allelic variants both in vitro and in vivo. Different types of CYP...