Effect of chewing gum containing nicotine and caffeine on energy expenditure and substrate utilization in men

• Published in: The American journal of clinical nutrition Vol. 77; no. 6; pp. 1442 - 1447
• Main Authors: Jessen, Anna B, Toubro, Søren, Astrup, Arne
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Clinical Nutrition 01.06.2003; American Society for Clinical Nutrition, Inc
• Subjects: Adult; adverse effects; Biological and medical sciences; Caffeine; Caffeine - administration & dosage; Chewing Gum; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Synergism; Effects; Energy; energy expenditure; Energy Metabolism - drug effects; Fundamental and applied biological sciences. Psychology; glucose; Humans; long term effects; Male; Men; Nicotine; Nicotine - administration & dosage; Nicotine - adverse effects; oxidation; Respiration - drug effects; respiratory quotient; Thermogenesis - drug effects; weight gain; cigarette smoking; caffeine; respiratory quotient; smoking cessation; weight control; carbohydrate oxidation; weight management; fatty acid oxidation; energy expenditure; Nicotine

Background: Nicotine replacement therapy limits weight gain after smoking cessation. This finding is partly attributable to the thermogenic effect of nicotine, which may be enhanced by caffeine. Objective: We assessed the acute thermogenic effects of chewing gum containing different doses of nicotin...