Association between a Protein Polymorphism in the Start Codon of the Vitamin D Receptor Gene and Severe Diabetic Retinopathy in C-Peptide-Negative Type 1 Diabetes

• Published in: The journal of clinical endocrinology and metabolism Vol. 90; no. 8; pp. 4803 - 4808
• Main Authors: Taverna, Mariano J., Selam, Jean-Louis, Slama, Gérard
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Oxford University Press 01.08.2005; Endocrine Society
• Subjects: Adult; Alleles; Associated diseases and complications; Biological and medical sciences; C-Peptide - blood; Calcitriol; Case-Control Studies; Codon, Initiator; Diabetes; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - epidemiology; Diabetes Mellitus, Type 1 - genetics; Diabetes. Impaired glucose tolerance; Diabetic Nephropathies - blood; Diabetic Nephropathies - epidemiology; Diabetic Nephropathies - genetics; Diabetic retinopathy; Diabetic Retinopathy - blood; Diabetic Retinopathy - epidemiology; Diabetic Retinopathy - genetics; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; European Continental Ancestry Group - genetics; Female; Gene frequency; Gene polymorphism; Glycated Hemoglobin A - metabolism; Humans; Male; Medical sciences; Middle Aged; Peptides; Polymorphism; Polymorphism, Genetic; Receptors, Calcitriol - genetics; Restriction fragment length polymorphism; Retina; Retinopathy; Risk Factors; Severity of Illness Index; Transcription initiation; Translation initiation; Vitamin D receptors; Vitamin D3; White people; Endocrinopathy; Immunopathology; Retinopathy; Genetic variability; Autoimmune disease; Genotype; C-Peptide; Eye disease; Codon; Gene; Vitamin D; Type 1 diabetes; Genetics; Endocrinology; Polymorphism; Biological receptor

Context: The vitamin D (VD) receptor (VDR) is extensively expressed in retina. The plasma concentration of 1,25-dihydroxyvitamin D3 has been inversely correlated with the severity of diabetic retinopathy (DR), which raises the possibility that VD, through its antiinflammatory, antioxidant, antiproli...