Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer

• Published in: Nature genetics Vol. 48; no. 10; pp. 1142 - 1150
• Main Authors: Guo, Haiyang, Ahmed, Musaddeque, Zhang, Fan, Yao, Cindy Q, Li, SiDe, Liang, Yi, Hua, Junjie, Soares, Fraser, Sun, Yifei, Langstein, Jens, Li, Yuchen, Poon, Christine, Bailey, Swneke D, Desai, Kinjal, Fei, Teng, Li, Qiyuan, Sendorek, Dorota H, Fraser, Michael, Prensner, John R, Pugh, Trevor J, Pomerantz, Mark, Bristow, Robert G, Lupien, Mathieu, Feng, Felix Y, Boutros, Paul C, Freedman, Matthew L, Walsh, Martin J, He, Housheng Hansen
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.10.2016; Nature Publishing Group
• Subjects: 13/1; 13/106; 38; 38/23; 38/43; 38/77; 631/208/205/2138; 631/67/589/466; Agriculture; Androgens; Animal Genetics and Genomics; Animals; Binding sites; Biomedicine; Cancer genetics; Cancer Research; Cell growth; Cell Line, Tumor; Chromatin - metabolism; Development and progression; Enhancer Elements, Genetic; Epigenetics; Gene Expression Regulation, Neoplastic; Gene Function; Genes; Genetic aspects; Genetic Predisposition to Disease; Genetic research; Genome-Wide Association Study; Genomes; Genomics; Genotype; Grants; Health aspects; Health risks; Human Genetics; Humans; Male; Mice; Mice, Inbred NOD; Polymorphism, Single Nucleotide; Prostate cancer; Prostatic Neoplasms - genetics; Proteins; Receptors, Androgen - metabolism; Regulation; Risk Factors; RNA polymerase; RNA, Long Noncoding - genetics; Signal Transduction; Single nucleotide polymorphisms; Studies; Transcription factors; Transcription Factors - metabolism; Xenograft Model Antitumor Assays

Housheng Hansen He and colleagues perform an integrated analysis and identify 45 candidate long noncoding RNAs (lncRNAs) associated with prostate cancer risk. They further show that a prostate cancer risk allele in the 8q24 region results in upregulation of the lncRNA PCAT1, which promotes prostate...