Physicochemical analysis of electrostatic foundation for DNA–protein interactions in chromatin transformations

• Published in: PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY Vol. 95; no. 1; pp. 23 - 49
• Main Authors: Korolev, Nikolay, Vorontsova, Olga V., Nordenskiöld, Lars
• Format: Journal Article Publication
• Language: English
• Published: England Elsevier Ltd 01.09.2007
• Subjects: Chromatin - genetics; Chromatin - metabolism; DNA - chemistry; DNA - genetics; DNA - metabolism; Epigenetic regulation; Histone chaperones; Histones - genetics; Histones - metabolism; Histone–DNA interactions; Molecular Chaperones - genetics; Molecular Chaperones - metabolism; Nuclear Proteins - chemistry; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Nucleosome assembly; Nucleosomes - genetics; Nucleosomes - metabolism; Phosphorylation; Polyelectrolyte complexes; RNA Polymerase II - genetics; RNA Polymerase II - metabolism; Static Electricity; Thermodynamics; Transcription, Genetic; Epigenetic regulation; Histone chaperones; Nucleosome assembly; Polyelectrolyte complexes; Histone–DNA interactions

Electrostatic interactions between DNA and DNA-packaging proteins, the histones, contribute substantially to stability of eukaryotic chromatin on all levels of its organization and are particularly important in formation of its elementary structural unit, the nucleosome. The release of DNA from the...