Understanding arsenic toxicity: Implications for environmental exposure and human health
Arsenic is a trace element and a metalloid which is prominently known as an environmental hazard. At present, rising health apprehensions are linked to emanating from a wide array of industrial, chemical, residential, agricultural, and technological sources, leading to extensive pollution of water,...
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| Published in | Journal of hazardous materials letters Vol. 5; p. 100090 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier B.V
01.11.2024
Elsevier |
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| Online Access | Get full text |
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| Abstract | Arsenic is a trace element and a metalloid which is prominently known as an environmental hazard. At present, rising health apprehensions are linked to emanating from a wide array of industrial, chemical, residential, agricultural, and technological sources, leading to extensive pollution of water, soil, and air ecosystems including flora, fauna and humans. It poses significant harm to biological organisms upon acute and chronic exposure. In this review, we delve into the reported experimental data that elaborates on arsenic as a toxicant, with particular emphasis on its occurrence, metabolism and diverse molecular mechanisms involved. It also includes the major molecular mechanisms leading to systemic toxicity with special emphasis on shedding light on the intricate ways it disrupts the nervous system.
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●Arsenic (As), a potent neurotoxicant shows negative effects on biological species.●Experimental studies provided significant insights into its molecular toxicities.●Arsenic's potential toxicity and its connection to neurodegenerative diseases and developmental disorders underscore the importance of comprehensive research and awareness to mitigate associated health risks. |
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| AbstractList | Arsenic is a trace element and a metalloid which is prominently known as an environmental hazard. At present, rising health apprehensions are linked to emanating from a wide array of industrial, chemical, residential, agricultural, and technological sources, leading to extensive pollution of water, soil, and air ecosystems including flora, fauna and humans. It poses significant harm to biological organisms upon acute and chronic exposure. In this review, we delve into the reported experimental data that elaborates on arsenic as a toxicant, with particular emphasis on its occurrence, metabolism and diverse molecular mechanisms involved. It also includes the major molecular mechanisms leading to systemic toxicity with special emphasis on shedding light on the intricate ways it disrupts the nervous system.
[Display omitted]
●Arsenic (As), a potent neurotoxicant shows negative effects on biological species.●Experimental studies provided significant insights into its molecular toxicities.●Arsenic's potential toxicity and its connection to neurodegenerative diseases and developmental disorders underscore the importance of comprehensive research and awareness to mitigate associated health risks. Arsenic is a trace element and a metalloid which is prominently known as an environmental hazard. At present, rising health apprehensions are linked to emanating from a wide array of industrial, chemical, residential, agricultural, and technological sources, leading to extensive pollution of water, soil, and air ecosystems including flora, fauna and humans. It poses significant harm to biological organisms upon acute and chronic exposure. In this review, we delve into the reported experimental data that elaborates on arsenic as a toxicant, with particular emphasis on its occurrence, metabolism and diverse molecular mechanisms involved. It also includes the major molecular mechanisms leading to systemic toxicity with special emphasis on shedding light on the intricate ways it disrupts the nervous system. |
| ArticleNumber | 100090 |
| Author | Singh, Dhirendra Pratap kaur, Ravidarshdeep Mehta, Tejal Garkal, Atul Bangar, Priyanka Sarode, Lopmudra Rawal, Rakesh |
| Author_xml | – sequence: 1 givenname: Ravidarshdeep surname: kaur fullname: kaur, Ravidarshdeep organization: Department of Biochemistry and Forensic Science, University School of Sciences, Gujarat University, Ahmedabad, Gujarat 380009, India – sequence: 2 givenname: Atul surname: Garkal fullname: Garkal, Atul organization: Department of Pharmaceutics, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat 382481, India – sequence: 3 givenname: Lopmudra surname: Sarode fullname: Sarode, Lopmudra organization: Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra 440033, India – sequence: 4 givenname: Priyanka surname: Bangar fullname: Bangar, Priyanka organization: Department of Pharmaceutics, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat 382481, India – sequence: 5 givenname: Tejal surname: Mehta fullname: Mehta, Tejal organization: Department of Pharmaceutics, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat 382481, India – sequence: 6 givenname: Dhirendra Pratap surname: Singh fullname: Singh, Dhirendra Pratap email: singh.dpratap@icmr.gov.in organization: Division of Biosciences, ICMR, National Institute of Occupational Health, Meghani Nagar, Ahmedabad, Gujarat 380016, India – sequence: 7 givenname: Rakesh orcidid: 0000-0002-7985-1187 surname: Rawal fullname: Rawal, Rakesh email: rakeshmrawal@gmail.com organization: Department of Biochemistry and Forensic Science, University School of Sciences, Gujarat University, Ahmedabad, Gujarat 380009, India |
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| Keywords | Hazardous materials Trace element Neurotoxicant Arsenic Toxic metals |
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