Obesity is a determinant of asthma control independent of inflammation and lung mechanics

• Published in: Chest Vol. 140; no. 3; p. 659
• Main Authors: Farah, Claude S, Kermode, Jessica A, Downie, Sue R, Brown, Nathan J, Hardaker, Kate M, Berend, Norbert, King, Gregory G, Salome, Cheryl M
• Format: Journal Article
• Language: English
• Published: United States 01.09.2011
• Subjects: Adrenal Cortex Hormones - administration & dosage; Adult; Asthma - drug therapy; Asthma - epidemiology; Asthma - physiopathology; Asthma - prevention & control; Body Mass Index; Bronchial Hyperreactivity; Bronchial Provocation Tests; Comorbidity; Female; Humans; Male; Middle Aged; Multivariate Analysis; Obesity - epidemiology; Obesity - physiopathology; Plethysmography; Respiratory Function Tests; Spirometry

It is unclear why obesity is associated with worse asthma control. We hypothesized that (1) obesity affects asthma control independent of spirometry, airway inflammation, and airway hyperresponsiveness (AHR) and (2) residual symptoms after resolution of inflammation are due to obesity-related change...