Secretion of β-lactam antibiotics in pure human pancreatic juice

• Published in: The American journal of surgery Vol. 150; no. 3; pp. 333 - 335
• Main Authors: Gregg, James A., Maher, Louise, DeGirolami, Paola C.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.09.1985; Elsevier
• Subjects: Acute Disease; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Bacterial Infections - prevention & control; Biological and medical sciences; Cefoxitin - administration & dosage; Cefoxitin - metabolism; Cefoxitin - therapeutic use; Cephalothin - administration & dosage; Cephalothin - metabolism; Cephalothin - therapeutic use; Cholangiopancreatography, Endoscopic Retrograde; Chronic Disease; Humans; Medical sciences; Pancreatic Juice - metabolism; Pancreatic Juice - microbiology; Pancreatitis - drug therapy; Pancreatitis - metabolism; Pancreatitis - microbiology; Pharmacology. Drug treatments; Premedication; Secretin; Human; Antibiotic; Digestive system; Pancreatitis; Metabolism; Pancreas; Pharmacokinetics

The secretion of cephalothin and cefoxitin in stimulated pure pancreatic juice was studied in 13 persons after intravenous administration of antibiotics. Of all these studied, three had acute relapsing pancreatitis, five chronic pancreatitis, and five were control subjects. Antibiotic levels were me...