Paranode length in the prefrontal cortex of subjects with major depression and rats under chronic unpredictable stress

• Published in: Journal of affective disorders Vol. 373; pp. 158 - 165
• Main Authors: Miguel-Hidalgo, José Javier, Kelly, Isabella, Rajkowska, Grazyna
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.03.2025
• Subjects: Adult; Aged; Aged, 80 and over; Aging; Animals; Cell Adhesion Molecules, Neuronal - metabolism; Depression; Depressive Disorder, Major - pathology; Disease Models, Animal; Female; Glia; Humans; Male; Microscopy, Confocal; Middle Aged; Myelin; Nerve Fibers, Myelinated - pathology; Nerve Growth Factors - metabolism; Prefrontal cortex; Prefrontal Cortex - pathology; Psychiatric/Mental Health; Rats; Stress; Stress, Psychological - pathology; White matter; Young Adult; Myelin; Aging; Depression; Prefrontal cortex; Glia; White matter; Stress

Experimental studies of major depressive disorder (MDD) and stress reveal connectivity disturbances of the prefrontal cortex (PFC) that may involve molecular and morphological changes in myelin and the axons it enwraps. These alterations may also affect the nodes of Ranvier (NR), myelin-bare axon st...