Investigation of the effect of the dual orexin receptor antagonist almorexant on ophthalmological, spermatogenic, and hormonal variables in healthy male subjects - Dingemanse, Jasper; Charef, Pascal; Black, Jed; Gouws, Chris (Biomedicine & pharmacotherapy, 2021)
Keywords: Acetamides - administration & dosage; Acetamides - adverse effects; Acetamides - blood; Acetamides - pharmacokinetics; Administration, Oral; Adult; Almorexant; Biomarkers - blood; Double-Blind Method; Drug Administration Schedule; Healthy Volunteers; Hormones; Hormones - blood; Humans; Isoquinolines - administration & dosage; Isoquinolines - adverse effects; Isoquinolines - blood; Isoquinolines - pharmacokinetics; Lacrimal Apparatus - drug effects; Lacrimal Apparatus - physiology; Male; Meibomian gland; Ophthalmology; Orexin; Orexin Receptor Antagonists - administration & dosage; Orexin Receptor Antagonists - adverse effects; Orexin Receptor Antagonists - blood; Orexin Receptor Antagonists - pharmacokinetics; Patient Safety; Prospective Studies; Risk Assessment; Sleep Aids, Pharmaceutical - administration & dosage; Sleep Aids, Pharmaceutical - adverse effects; Sleep Aids, Pharmaceutical - blood; Sleep Aids, Pharmaceutical - pharmacokinetics; South Africa; Spermatogenesis; Spermatogenesis - drug effects; Tears; Time Factors; Young Adult; South Africa; Hormones; Ophthalmology; Spermatogenesis; Meibomian gland; Orexin; Almorexant