Correlations of patch test reactivity and the repeated open application test (ROAT)/provocative use test (PUT)

• Published in: Food and chemical toxicology Vol. 42; no. 11; pp. 1719 - 1725
• Main Authors: Villarama, Clarissa D., Maibach, Howard I.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.11.2004; New York, NY Elsevier Science
• Subjects: Acrolein - adverse effects; Acrolein - analogs & derivatives; Biological and medical sciences; Chromium - adverse effects; Dermatitis, Allergic Contact - diagnosis; Dose-Response Relationship, Immunologic; Eugenol - adverse effects; Eugenol - analogs & derivatives; Formaldehyde - adverse effects; Humans; Maximum Allowable Concentration; Medical sciences; Patch Tests - methods; Patch Tests - standards; Provocative use test (PUT); Repeated open application tests (ROAT); Reproducibility of Results; Resins, Plant - adverse effects; Sensitivity and Specificity; Serial dilution patch tests; Terpenes - adverse effects; Time Factors; Toxicology; Repeated open application tests (ROAT); Serial dilution patch tests; Provocative use test (PUT); Dilution; Patch; Skin test

The clinical relevance of patch test reactions is often difficult to determine. Use tests have been developed to further evaluate the significance of patch test results. We review studies that have defined correlations between the threshold concentrations at patch testing and the outcome of use test...