Deleterious role of trace elements – Silica and lead in the development of chronic kidney disease

• Published in: Chemosphere (Oxford) Vol. 177; pp. 239 - 249
• Main Authors: Mascarenhas, Starlaine, Mutnuri, Srikanth, Ganguly, Anasuya
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2017
• Subjects: Adult; Anthropometry; Anti-Inflammatory Agents, Non-Steroidal - chemistry; Apoptosis; bioavailability; biomarkers; Biomarkers - blood; blood; blood glucose; Blood Glucose - analysis; cations; Cell Cycle; Cell Line; Cell Line, Tumor; Cell Proliferation; Central America; chronic exposure; CKDu; Creatinine - blood; developing countries; diabetes; drinking water; Drinking Water - analysis; Emerging-contaminant-silica; Environmental-nephrotoxins; etiology; Female; Groundwater; Groundwater - analysis; HEK293 Cells; Humans; Hydrogen-Ion Concentration; hypertension; India; kidney diseases; Lead; Lead - analysis; Lead - blood; Male; Metals - chemistry; nephrotoxicity; nonsteroidal anti-inflammatory agents; Renal Insufficiency, Chronic - chemically induced; Renal Insufficiency, Chronic - epidemiology; Risk Factors; silica; Silicon Dioxide - analysis; Sri Lanka; Trace Elements - analysis; Trace-elements; Urea - blood; Central America; Sri Lanka; India; TDS; CKDu; FACS; A498; MTT; BIS; HEK; DMEM; FITC; GFR; Groundwater; Environmental-nephrotoxins; APHA; Lead; PI; Emerging-contaminant-silica; ICP-MS; CTN; CKD; NSAID's; Trace-elements; SiO2; BMI; WHO

Chronic-Kidney-Disease of Unknown-etiology (CKDu) has been reported in developing-countries like Sri-Lanka, India and Central-America without sparing the Indian sub-district (namely Canacona) located in south-Goa. The disease etiology is unlinked to common causes of diabetes and hypertension and ass...