Microglia in epilepsy
Epilepsy is one of most common chronic neurological disorders, and the antiseizure medications developed by targeting neurocentric mechanisms have not effectively reduced the proportion of patients with drug-resistant epilepsy. Further exploration of the cellular or molecular mechanism of epilepsy i...
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| Published in | Neurobiology of disease Vol. 185; p. 106249 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier
01.09.2023
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Epilepsy is one of most common chronic neurological disorders, and the antiseizure medications developed by targeting neurocentric mechanisms have not effectively reduced the proportion of patients with drug-resistant epilepsy. Further exploration of the cellular or molecular mechanism of epilepsy is expected to provide new options for treatment. Recently, more and more researches focus on brain network components other than neurons, among which microglia have attracted much attention for their diverse biological functions. As the resident immune cells of the central nervous system, microglia have highly plastic transcription, morphology and functional characteristics, which can change dynamically in a context-dependent manner during the progression of epilepsy. In the pathogenesis of epilepsy, highly reactive microglia interact with other components in the epileptogenic network by performing crucial functions such as secretion of soluble factors and phagocytosis, thus continuously reshaping the landscape of the epileptic brain microenvironment. Indeed, microglia appear to be both pro-epileptic and anti-epileptic under the different spatiotemporal contexts of disease, rendering interventions targeting microglia biologically complex and challenging. This comprehensive review critically summarizes the pathophysiological role of microglia in epileptic brain homeostasis alterations and explores potential therapeutic or modulatory targets for epilepsy targeting microglia. |
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| AbstractList | Epilepsy is one of most common chronic neurological disorders, and the antiseizure medications developed by targeting neurocentric mechanisms have not effectively reduced the proportion of patients with drug-resistant epilepsy. Further exploration of the cellular or molecular mechanism of epilepsy is expected to provide new options for treatment. Recently, more and more researches focus on brain network components other than neurons, among which microglia have attracted much attention for their diverse biological functions. As the resident immune cells of the central nervous system, microglia have highly plastic transcription, morphology and functional characteristics, which can change dynamically in a context-dependent manner during the progression of epilepsy. In the pathogenesis of epilepsy, highly reactive microglia interact with other components in the epileptogenic network by performing crucial functions such as secretion of soluble factors and phagocytosis, thus continuously reshaping the landscape of the epileptic brain microenvironment. Indeed, microglia appear to be both pro-epileptic and anti-epileptic under the different spatiotemporal contexts of disease, rendering interventions targeting microglia biologically complex and challenging. This comprehensive review critically summarizes the pathophysiological role of microglia in epileptic brain homeostasis alterations and explores potential therapeutic or modulatory targets for epilepsy targeting microglia. |
| ArticleNumber | 106249 |
| Author | Xu, Da Deng, Xue-Jun Yu, Cheng |
| Author_xml | – sequence: 1 givenname: Cheng surname: Yu fullname: Yu, Cheng organization: Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, Hubei Province 430022, China – sequence: 2 givenname: Xue-Jun surname: Deng fullname: Deng, Xue-Jun organization: Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, Hubei Province 430022, China – sequence: 3 givenname: Da surname: Xu fullname: Xu, Da email: 498688793@qq.com organization: Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, Hubei Province 430022, China. Electronic address: 498688793@qq.com |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37536386$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_3390_brainsci14010071 crossref_primary_10_3390_life14050582 crossref_primary_10_1016_j_prp_2024_155146 crossref_primary_10_1007_s10571_023_01429_2 crossref_primary_10_1016_j_neubiorev_2024_105731 crossref_primary_10_3389_frdem_2024_1404841 crossref_primary_10_3390_ijms25136894 |
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| Keywords | epilepsy phagocytosis crosstalk neuroinflammation neurogenesis drug-resistance activation microglia oxidative stress |
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