Structure-based design of small peptide inhibitors of protein kinase CK2 subunit interaction

• Published in: Biochemical journal Vol. 408; no. 3; pp. 363 - 373
• Main Authors: Laudet, Béatrice, Barette, Caroline, Dulery, Vincent, Renaudet, Olivier, Dumy, Pascal, Metz, Alexandra, Prudent, Renaud, Deshiere, Alexandre, Dideberg, Otto, Filhol, Odile, Cochet, Claude
• Format: Journal Article
• Language: English
• Published: England Portland Press 15.12.2007; Portland Press Ltd
• Subjects: Amino Acid Sequence; Base Sequence; Casein Kinase II; Casein Kinase II - antagonists & inhibitors; Casein Kinase II - chemistry; Casein Kinase II - genetics; Casein Kinase II - metabolism; Catalysis; Crystallography, X-Ray; DNA Primers; HeLa Cells; Humans; Life Sciences; Ligands; Mutagenesis, Site-Directed; Peptides; Peptides - chemistry; Peptides - metabolism; Peptides - pharmacology; Protein Conformation; Protein Kinase Inhibitors; Protein Kinase Inhibitors - chemistry; Protein Kinase Inhibitors - metabolism; Protein Kinase Inhibitors - pharmacology; Recombinant Proteins; Recombinant Proteins - antagonists & inhibitors; Recombinant Proteins - chemistry; Recombinant Proteins - genetics; Recombinant Proteins - metabolism; Structure-Activity Relationship; Surface Plasmon Resonance; Life Sciences

X-ray crystallography studies, as well as live-cell fluorescent imaging, have recently challenged the traditional view of protein kinase CK2. Unbalanced expression of catalytic and regulatory CK2 subunits has been observed in a variety of tissues and tumours. Thus the potential intersubunit flexibil...