Low concentrations of dibromoacetic acid and N-nitrosodimethylamine induce several stimulatory effects in the invertebrate model Caenorhabditis elegans

• Published in: Chemosphere (Oxford) Vol. 124; pp. 122 - 128
• Main Authors: Baberschke, Nora, Steinberg, Christian E.W., Saul, Nadine
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2015
• Subjects: Acetates - toxicity; Animals; Body Size - drug effects; Caenorhabditis elegans - drug effects; Caenorhabditis elegans - physiology; Dibromoacetic acid; Dimethylnitrosamine - toxicity; Dose-Response Relationship, Drug; Down-regulation; Energy conservation; Energy Metabolism - drug effects; Environmental Pollutants - toxicity; Gene transcription; Genes; Invertebrates; Life history traits; Life span; Longevity - drug effects; Low concentrations; N-nitrosodimethylamine; Stimulatory effects; Stress concentration; Stresses; Toxic; Toxicology; Stimulatory effects; Life history traits; N-nitrosodimethylamine; Dibromoacetic acid; Down-regulation; Gene transcription

•Dibromoacetic acid and N-nitrosodimethylamine are ubiquitously distributed.•Both are considered toxic and carcinogenic at high concentrations.•Stimulatory effects on C. elegans were detected at relatively low concentrations.•DBAA and NDMA have life-extending effects and increase body length.•The do...