Pharmacokinetics and Dose Proportionality of Fentanyl Effervescent Buccal Tablets in Healthy Volunteers

• Published in: Clinical pharmacokinetics Vol. 44; no. 12; pp. 1279 - 1286
• Main Authors: Darwish, Mona, Tempero, Kenneth, Kirby, Mary, Thompson, Jeffrey
• Format: Journal Article
• Language: English
• Published: Auckland Adis international 01.01.2005; Wolters Kluwer Health, Inc
• Subjects: Administration, Buccal; Adult; Analgesics; Analgesics, Opioid - administration & dosage; Analgesics, Opioid - adverse effects; Analgesics, Opioid - blood; Analgesics, Opioid - pharmacokinetics; Biological and medical sciences; Cross-Over Studies; Female; Fentanyl - administration & dosage; Fentanyl - adverse effects; Fentanyl - blood; Fentanyl - pharmacokinetics; Healthy Volunteers; Humans; Male; Medical sciences; Neuropharmacology; Pharmacology. Drug treatments; Tablets; Human; Agonist; Healthy subject; μ Opioid receptor; Oral administration; Fentanyl; Opiates; Narcotic analgesic; Effervescent form; Dose activity relation; Dosage form; Tablet; Pharmacokinetics
• ISSN: 0312-5963
• DOI: 10.2165/00003088-200544120-00006

Fentanyl effervescent buccal tablets (FEBT) are designed to enhance the rate and efficiency of fentanyl absorption through the buccal mucosa. This study was undertaken to characterise the pharmacokinetics and assess the dose proportionality of FEBT in healthy volunteers within the potential therapeu...