Genetic polymorphism of CYP2C9 in a Vietnamese Kinh population

• Published in: Therapeutic drug monitoring Vol. 27; no. 2; p. 208
• Main Authors: Lee, Sang Seop, Kim, Kang-Mi, Thi-Le, Huong, Yea, Sung-Su, Cha, In-June, Shin, Jae-Gook
• Format: Journal Article
• Language: English
• Published: United States 01.04.2005
• Subjects: Alleles; Aryl Hydrocarbon Hydroxylases - genetics; Aryl Hydrocarbon Hydroxylases - metabolism; Asian Continental Ancestry Group - ethnology; Asian Continental Ancestry Group - genetics; Cytochrome P-450 CYP2C9; Genetic Carrier Screening - methods; Humans; Pharmacogenetics; Polymerase Chain Reaction - methods; Polymorphism, Genetic - genetics; Vietnam - ethnology
• DOI: 10.1097/01.ftd.0000153402.91854.42
• ISSN: 0163-4356

Cytochrome P450 2C9 (CYP2C9) shows genetic polymorphism with high interethnic variation, but no report has addressed the genetic polymorphism in the Vietnamese population. In the present study, the distribution of 2 common allelic variations of CYP2C9 was investigated in Vietnamese Kinh population, a major ethnic group in Vietnam. Genomic DNA from 157 Vietnamese subjects was amplified by polymerase chain reaction, and the presence of CYP2C9*2 and CYP2C9*3 allelic variants was determined by pyrosequencing. Among 157 Vietnamese subjects, no subject with the CYP2C9*2 allele was detected, but 7 subjects were heterozygous for the CYP2C9*3 allele. The allele frequency of CYP2C9*3 was 2.2% in the Vietnamese Kinh population. This genotype distribution was well correlated with previous reports suggesting no occurrence of CYP2C9*2 in Asians. These results suggest that CYP2C9*2 may be absent in Vietnamese Kinh population and that CYP2C9*3 is major allelic variant that causes interindividual variation of drug responses to CYP2C9 substrate drugs in the Vietnamese Kinh population.