Excessive ethanol consumption under exposure to lead intensifies disorders in bone metabolism: A study in a rat model

• Published in: Chemico-biological interactions Vol. 203; no. 2; pp. 486 - 501
• Main Authors: Kupraszewicz, Elżbieta, Brzóska, Malgorzata M.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 25.04.2013
• Subjects: adverse effects; alcohol abuse; alcohol drinking; Alcohol Drinking - adverse effects; alkaline phosphatase; animal models; Animals; blood; blood serum; Bone Density; Bone Density - drug effects; Bone Diseases; Bone Diseases - chemically induced; Bone Diseases - metabolism; Bone Diseases - pathology; Bone Diseases - physiopathology; bone formation; Bone mineral status; Bone Remodeling; Bone Remodeling - drug effects; Bone turnover; Calciotropic hormones; calcitonin; calcium; Calcium - blood; Calcium - urine; chemically induced; collagen; Disease Models, Animal; drinking water; drug effects; Drug Interactions; Environmental Pollutants; Environmental Pollutants - blood; Environmental Pollutants - metabolism; Environmental Pollutants - toxicity; Ethanol; Ethanol - adverse effects; femur; Femur - drug effects; Femur - metabolism; Femur - pathology; Femur - physiopathology; hormonal regulation; humans; inorganic phosphorus; Lead; Lead - blood; Lead - metabolism; Lead - toxicity; Male; metabolism; mineral content; Mineral metabolism; Organ Size; Organ Size - drug effects; Organophosphorus Compounds; Organophosphorus Compounds - blood; Organophosphorus Compounds - urine; osteocalcin; Parathyroid Hormone; Parathyroid Hormone - blood; pathology; physiopathology; Rats; Rats, Wistar; resorption; risk; skeleton; toxicity; transcription factor NF-kappa B; urine; xenobiotics; s-ALP; ALP; PTH; CTX; OPG; 1,25(OH)2D; organic comp; Calciotropic hormones; Et; Pb; sRANKL; DW; OC; Ca/Pi; Ca/DW; Lead; bC-ALP; Pi; bT-ALP; AW/OW; PINP; WW; Ethanol; OW; Bone turnover; Mineral metabolism; AW/DW; CT; 25OHD; AW; Ca/AW; mineral comp; Bone mineral status; Ca

► Exposure to lead (Pb) or/and ethanol (Et) disturbs bone metabolism in male rats. ► Et abuse under exposure to Pb increases the risk of bone damage. ► Excessive Et consumption decreases Pb accumulation in the skeleton. ► Destroying of the RANK/RANKL/OPG system is involved in interactive action of P...