Optimal Selection of SNP Markers for Disease Association Studies

• Published in: Human heredity Vol. 58; no. 3/4; pp. 190 - 202
• Main Authors: Halldórsson, Bjarni V., Istrail, Sorin, De La Vega, Francisco M.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2004
• Subjects: Algorithms; Alleles; Disease; Genetic Diseases, Inborn - genetics; Genetic Markers; Genetic Predisposition to Disease; Genetic Techniques; Genetics; Genotype; Genotype & phenotype; Haplotypes; Heredity; Humans; Linkage Disequilibrium; Models, Genetic; Models, Statistical; Multivariate Analysis; Polymorphism; Polymorphism, Single Nucleotide; Principal Component Analysis; Software; Time Factors; Association mapping; Single nucleotide polymorphism; Haplotype tagging; Minimum informative subset; Linkage disequilibrium; htSNP

Genetic association studies with population samples hold the promise of uncovering the susceptibility genes underlying the heritability of complex or common disease. Most association studies rely on the use of surrogate markers, single-nucleotide polymorphism (SNP) being the most suitable due to the...