Transcriptional investigation of the toxic mechanisms of perfluorooctane sulfonate in rats based on an RNA-Seq approach

• Published in: Chemosphere (Oxford) Vol. 329; p. 138629
• Main Authors: Wang, Tianrun, Zhao, Xuying, Liu, Tianze, Zhang, Jiguang, Qiu, Jing, Li, Mei, Weng, Rui
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2023
• Subjects: Alkanesulfonic Acids - chemistry; animal models; Animals; B-lymphocytes; body weight changes; endoplasmic reticulum; Environmental Pollutants - metabolism; Environmental Pollutants - toxicity; Fluorocarbons - chemistry; genes; Hub genes; kidneys; liver; Liver - metabolism; metabolism; myeloid leukemia; perfluorooctane sulfonic acid; Persistent organic pollutants; PFOS; phagocytosis; protein-protein interactions; quantitative polymerase chain reaction; Rats; RNA-Seq; sequence analysis; Signalling pathway; spliceosomes; toxicity; transcription (genetics); transcriptomics; ultrastructure; Signalling pathway; Hub genes; Persistent organic pollutants; PFOS

Perfluorooctane sulfonate (PFOS) was widely used in industrial applications before it was listed as a persistent organic pollutant by the Conference of the Parties in the Stockholm Convention in 2009. Although the potential toxicity of PFOS has been studied, its toxic mechanisms remain largely undef...