Pharmacokinetic comparison between quercetin and quercetin 3-O-β-glucuronide in rats by UHPLC-MS/MS

• Published in: Scientific reports Vol. 6; no. 1; p. 35460
• Main Authors: Yang, Le-Le, Xiao, Na, Li, Xiao-Wei, Fan, Yong, Alolga, Raphael N., Sun, Xiao-Yue, Wang, Shi-Lei, Li, Ping, Qi, Lian-Wen
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.10.2016; Nature Publishing Group
• Subjects: 140/131; 631/1647/296; 631/92/349; 639/638/11; Administration, Oral; Animals; Chromatography, High Pressure Liquid - methods; Humanities and Social Sciences; Injections, Intravenous; Male; multidisciplinary; Quercetin - administration & dosage; Quercetin - analogs & derivatives; Quercetin - blood; Quercetin - chemistry; Quercetin - pharmacokinetics; Rats, Sprague-Dawley; Reproducibility of Results; Science; Tandem Mass Spectrometry - methods; Tissue Distribution

Quercetin is a natural flavonoid widely distributed in human diet and functional foods. Quercetin 3- O - β -glucuronide (Q3G) is present in wine and some medicinal plants. Quercetin and Q3G may be metabolized from each other in vivo . While quercetin has been the subject of many studies, the pharmac...