Pharmacokinetic comparison between quercetin and quercetin 3-O-β-glucuronide in rats by UHPLC-MS/MS
Quercetin is a natural flavonoid widely distributed in human diet and functional foods. Quercetin 3- O - β -glucuronide (Q3G) is present in wine and some medicinal plants. Quercetin and Q3G may be metabolized from each other in vivo . While quercetin has been the subject of many studies, the pharmac...
Saved in:
| Published in | Scientific reports Vol. 6; no. 1; p. 35460 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
24.10.2016
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Quercetin is a natural flavonoid widely distributed in human diet and functional foods. Quercetin 3-
O
-
β
-glucuronide (Q3G) is present in wine and some medicinal plants. Quercetin and Q3G may be metabolized from each other
in vivo
. While quercetin has been the subject of many studies, the pharmacokinetic profiles of quercetin and Q3G (in animals) have not yet been compared. Herein, we prepared a column-based method for rapid isolation of Q3G from
Nelumbo nucifera
. Then, we developed an UHPLC-MS/MS method to compare the pharmacokinetics of quercetin and Q3G. Our results showed that the plasma concentration-time curves of quercetin and Q3G show two maxima (
T
max
1
≈ 0.75 h,
T
max
2
≈ 5 h). After oral administration of 100 mg/kg quercetin or 100 mg/kg Q3G in rats, predominantly Q3G was detected in plasma with
AUC
at 39529.2 ± 6108.2 mg·h·L
−1
or 24625.1 ± 1563.8 mg·h·L
−1
, 18-fold higher than quercetin with
AUC
at 1583.9 ± 583.3 mg·h·L
−1
or 1394.6 ± 868.1 mg·h·L
−1
, respectively. After intravenous injection of 10 mg/kg in rats, Q3G showed extensive tissue uptake in kidney (409.2 ± 118.4 ng/g), liver (166.1 ± 52.9 ng/g), heart (97.7 ± 22.6 ng/g), and brain (5.8 ± 1.2 ng/g). In conclusion, we have shown that Q3G is a major active component in plasma and tissue for oral administration of quercetin or Q3G. |
|---|---|
| AbstractList | Quercetin is a natural flavonoid widely distributed in human diet and functional foods. Quercetin 3-
O
-
β
-glucuronide (Q3G) is present in wine and some medicinal plants. Quercetin and Q3G may be metabolized from each other
in vivo
. While quercetin has been the subject of many studies, the pharmacokinetic profiles of quercetin and Q3G (in animals) have not yet been compared. Herein, we prepared a column-based method for rapid isolation of Q3G from
Nelumbo nucifera
. Then, we developed an UHPLC-MS/MS method to compare the pharmacokinetics of quercetin and Q3G. Our results showed that the plasma concentration-time curves of quercetin and Q3G show two maxima (
T
max
1
≈ 0.75 h,
T
max
2
≈ 5 h). After oral administration of 100 mg/kg quercetin or 100 mg/kg Q3G in rats, predominantly Q3G was detected in plasma with
AUC
at 39529.2 ± 6108.2 mg·h·L
−1
or 24625.1 ± 1563.8 mg·h·L
−1
, 18-fold higher than quercetin with
AUC
at 1583.9 ± 583.3 mg·h·L
−1
or 1394.6 ± 868.1 mg·h·L
−1
, respectively. After intravenous injection of 10 mg/kg in rats, Q3G showed extensive tissue uptake in kidney (409.2 ± 118.4 ng/g), liver (166.1 ± 52.9 ng/g), heart (97.7 ± 22.6 ng/g), and brain (5.8 ± 1.2 ng/g). In conclusion, we have shown that Q3G is a major active component in plasma and tissue for oral administration of quercetin or Q3G. Quercetin is a natural flavonoid widely distributed in human diet and functional foods. Quercetin 3-O-β-glucuronide (Q3G) is present in wine and some medicinal plants. Quercetin and Q3G may be metabolized from each other in vivo. While quercetin has been the subject of many studies, the pharmacokinetic profiles of quercetin and Q3G (in animals) have not yet been compared. Herein, we prepared a column-based method for rapid isolation of Q3G from Nelumbo nucifera. Then, we developed an UHPLC-MS/MS method to compare the pharmacokinetics of quercetin and Q3G. Our results showed that the plasma concentration-time curves of quercetin and Q3G show two maxima (T ≈ 0.75 h, T ≈ 5 h). After oral administration of 100 mg/kg quercetin or 100 mg/kg Q3G in rats, predominantly Q3G was detected in plasma with AUC at 39529.2 ± 6108.2 mg·h·L or 24625.1 ± 1563.8 mg·h·L , 18-fold higher than quercetin with AUC at 1583.9 ± 583.3 mg·h·L or 1394.6 ± 868.1 mg·h·L , respectively. After intravenous injection of 10 mg/kg in rats, Q3G showed extensive tissue uptake in kidney (409.2 ± 118.4 ng/g), liver (166.1 ± 52.9 ng/g), heart (97.7 ± 22.6 ng/g), and brain (5.8 ± 1.2 ng/g). In conclusion, we have shown that Q3G is a major active component in plasma and tissue for oral administration of quercetin or Q3G. |
| ArticleNumber | 35460 |
| Author | Sun, Xiao-Yue Li, Ping Qi, Lian-Wen Yang, Le-Le Xiao, Na Li, Xiao-Wei Wang, Shi-Lei Fan, Yong Alolga, Raphael N. |
| Author_xml | – sequence: 1 givenname: Le-Le surname: Yang fullname: Yang, Le-Le organization: State Key Laboratory of Natural Medicines, China Pharmaceutical University – sequence: 2 givenname: Na surname: Xiao fullname: Xiao, Na organization: State Key Laboratory of Natural Medicines, China Pharmaceutical University – sequence: 3 givenname: Xiao-Wei surname: Li fullname: Li, Xiao-Wei organization: State Key Laboratory of Natural Medicines, China Pharmaceutical University – sequence: 4 givenname: Yong surname: Fan fullname: Fan, Yong organization: State Key Laboratory of Natural Medicines, China Pharmaceutical University – sequence: 5 givenname: Raphael N. surname: Alolga fullname: Alolga, Raphael N. organization: State Key Laboratory of Natural Medicines, China Pharmaceutical University – sequence: 6 givenname: Xiao-Yue surname: Sun fullname: Sun, Xiao-Yue organization: State Key Laboratory of Natural Medicines, China Pharmaceutical University – sequence: 7 givenname: Shi-Lei surname: Wang fullname: Wang, Shi-Lei organization: State Key Laboratory of Natural Medicines, China Pharmaceutical University – sequence: 8 givenname: Ping surname: Li fullname: Li, Ping organization: State Key Laboratory of Natural Medicines, China Pharmaceutical University – sequence: 9 givenname: Lian-Wen surname: Qi fullname: Qi, Lian-Wen organization: State Key Laboratory of Natural Medicines, China Pharmaceutical University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27775094$$D View this record in MEDLINE/PubMed |
| BookMark | eNptkdFOwjAUhhuDEUQufAGzW00qXbeu242JISomEEiQ66XtOihuLXabhtfyQXwmS1CCht6c9pzv_5v85xy0tNESgEsf3fooiPuVleuAhBE6AR2MQgJxgHHr4N4GvapaIXcITkI_OQNtTCklKAk7IJsumS2ZMK9Ky1oJT5hyzayqjPa4rD-k1N5bI61wQ-0xnR28AjiBX59wUTSisUarTHqua1ldeXzjzYfT0QCOZ_3x7AKc5qyoZO-ndsH88eFlMISjydPz4H4EReijGhIu85iHkue5iHIkkI85ZRnCcZYQTKiPqAj8KIxELCjncZZzh7EEUUxkkoRBF9ztfNcNL2UmpK4tK9K1VSWzm9Qwlf6daLVMF-Y9JYgSmmBncHVosFf-5uWA6x0grKlc8vke8VG6XUe6X4dj-_9YoWpWK7P9WxVHFTc7ReVc9ULadGUaq11kR-BvC4qdvw |
| CitedBy_id | crossref_primary_10_1038_s41598_024_61779_9 crossref_primary_10_1002_bkcs_11926 crossref_primary_10_3390_cancers14246258 crossref_primary_10_1038_s41593_019_0372_9 crossref_primary_10_1007_s10787_024_01566_0 crossref_primary_10_1039_D1OB01275D crossref_primary_10_1248_cpb_c20_00562 crossref_primary_10_1002_jssc_202100906 crossref_primary_10_1515_ntrev_2022_0548 crossref_primary_10_1126_sciadv_adr1719 crossref_primary_10_3390_ijms23010433 crossref_primary_10_29235_1814_6023_2022_19_2_219_229 crossref_primary_10_1002_efd2_137 crossref_primary_10_3390_ijms252212091 crossref_primary_10_1002_bmc_4016 crossref_primary_10_3390_molecules25204592 crossref_primary_10_1007_s11130_020_00852_w crossref_primary_10_1016_j_humgen_2024_201372 crossref_primary_10_1021_acsomega_3c00429 crossref_primary_10_1590_fst_35518 crossref_primary_10_1080_27697061_2022_2089403 crossref_primary_10_1016_j_fct_2020_111606 crossref_primary_10_1016_j_jddst_2017_05_007 crossref_primary_10_1021_acs_jafc_9b01782 crossref_primary_10_1039_D2FO03122A crossref_primary_10_1038_s41598_017_02895_7 crossref_primary_10_1080_15440478_2023_2290856 crossref_primary_10_1016_j_jep_2019_112204 crossref_primary_10_3390_molecules27041319 crossref_primary_10_1590_fst_87322 crossref_primary_10_1016_j_indcrop_2019_111473 crossref_primary_10_3389_fphar_2021_707687 crossref_primary_10_1021_acs_jafc_2c05836 crossref_primary_10_1002_bio_4638 crossref_primary_10_3390_ph15081019 crossref_primary_10_1002_cbdv_202400752 crossref_primary_10_3390_antiox12051136 crossref_primary_10_3390_pharmaceutics15082036 crossref_primary_10_1002_smll_202409748 crossref_primary_10_3390_antiox11091811 crossref_primary_10_1002_jssc_202001068 crossref_primary_10_3136_fstr_FSTR_D_21_00264 crossref_primary_10_3390_antiox10060909 crossref_primary_10_1007_s40495_024_00388_6 crossref_primary_10_1016_j_prmcm_2023_100339 crossref_primary_10_3390_pharmaceutics13060782 crossref_primary_10_1016_j_cjac_2022_100125 crossref_primary_10_1055_s_0044_1791559 crossref_primary_10_2174_1389557523666230214101821 crossref_primary_10_3390_molecules23102514 crossref_primary_10_1016_j_jep_2018_06_003 crossref_primary_10_3390_antibiotics12061013 crossref_primary_10_3389_fphar_2022_909945 crossref_primary_10_1186_s12906_018_2418_z crossref_primary_10_1016_j_intimp_2017_12_022 crossref_primary_10_3390_molecules23071542 crossref_primary_10_7717_peerj_6665 crossref_primary_10_3389_fendo_2024_1445750 crossref_primary_10_3389_fvets_2023_1218025 |
| Cites_doi | 10.1254/jphs.10R38FM 10.1021/jf9808527 10.1016/j.abb.2014.05.025 10.1016/j.freeradbiomed.2004.01.002 10.1179/135100099101534800 10.1016/S0014-5793(99)01160-6 10.1007/BF00597593 10.1016/S0891-5849(01)00522-6 10.1006/abbi.2000.2123 10.1002/mnfr.201200569 10.1080/10715760100301421 10.1016/S0014-5793(97)01367-7 10.1016/j.bcp.2011.08.010 10.1016/j.lfs.2005.04.072 10.1016/S0891-5849(00)00416-0 10.1016/j.bmc.2004.10.020 10.1079/BJN20061809 10.1016/S0014-5793(97)00467-5 10.1002/mnfr.201100378 10.1021/jf010713g 10.1093/jn/131.7.1938 10.1016/j.bbrc.2013.10.168 10.1093/ajcn/80.1.15 10.1021/jf3001857 10.1016/j.ijpharm.2006.12.046 10.1038/sj.bjp.0704064 10.1124/dmd.31.6.805 10.1016/j.aca.2012.02.051 10.1080/10715760000301181 10.1016/S0006-2952(03)00039-X 10.1007/s00394-015-0862-9 10.1096/fj.12-212118 10.1016/j.chroma.2011.12.098 10.1016/S0891-5849(01)00803-6 10.1016/S0014-5793(98)00367-6 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2016 Copyright © 2016, The Author(s) 2016 The Author(s) |
| Copyright_xml | – notice: The Author(s) 2016 – notice: Copyright © 2016, The Author(s) 2016 The Author(s) |
| DBID | C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 5PM |
| DOI | 10.1038/srep35460 |
| DatabaseName | SpringerOpen Free (Free internet resource, activated by CARLI) CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
| DatabaseTitleList | CrossRef MEDLINE |
| Database_xml | – sequence: 1 dbid: C6C name: Springer Nature Link OA Free Journals url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 2045-2322 |
| ExternalDocumentID | PMC5075792 27775094 10_1038_srep35460 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Comparative Study |
| GroupedDBID | 0R~ 3V. 4.4 53G 5VS 7X7 88A 88E 88I 8FE 8FH 8FI 8FJ AAFWJ AAJSJ AAKDD ABDBF ABUWG ACGFS ACSMW ACUHS ADBBV ADRAZ AENEX AEUYN AFKRA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI C6C CCPQU DIK DWQXO EBD EBLON EBS EJD ESX FYUFA GNUQQ GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE KQ8 LK8 M0L M1P M2P M48 M7P M~E NAO OK1 PIMPY PQQKQ PROAC PSQYO RNT RNTTT RPM SNYQT UKHRP AASML AAYXX AFPKN CITATION PHGZM PHGZT CGR CUY CVF ECM EIF NPM 5PM PJZUB PPXIY PQGLB |
| ID | FETCH-LOGICAL-c410t-5bef8b4ebffc6f0c012b7ad028d95257107c31646c8c7bb8dfb6f0a90725e9943 |
| IEDL.DBID | M48 |
| ISSN | 2045-2322 |
| IngestDate | Thu Aug 21 18:05:54 EDT 2025 Wed Feb 19 02:44:05 EST 2025 Tue Jul 01 04:02:09 EDT 2025 Thu Apr 24 23:06:10 EDT 2025 Fri Feb 21 02:38:28 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c410t-5bef8b4ebffc6f0c012b7ad028d95257107c31646c8c7bb8dfb6f0a90725e9943 |
| Notes | These authors contributed equally to this work. |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1038/srep35460 |
| PMID | 27775094 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_5075792 pubmed_primary_27775094 crossref_primary_10_1038_srep35460 crossref_citationtrail_10_1038_srep35460 springer_journals_10_1038_srep35460 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 20161024 2016-10-24 |
| PublicationDateYYYYMMDD | 2016-10-24 |
| PublicationDate_xml | – month: 10 year: 2016 text: 20161024 day: 24 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Scientific reports |
| PublicationTitleAbbrev | Sci Rep |
| PublicationTitleAlternate | Sci Rep |
| PublicationYear | 2016 |
| Publisher | Nature Publishing Group UK Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group |
| References | Manach (CR31) 1997; 409 Kashiwada (CR7) 2005; 13 Moon, Tsushida, Nakahara, Terao (CR20) 2001; 30 Sesink, O’Leary, Hollman (CR15) 2001; 131 Shirai, Moon, Tsushida, Terao (CR9) 2001; 49 Chen (CR23) 2012; 724 Kitanov (CR6) 1988; 24 Plumb, Price, Williamson (CR8) 1999; 4 Day, Gee, DuPont, Johnson, Williamson (CR12) 2003; 65 CR36 Ishizawa (CR3) 2011; 115 Spencer (CR14) 1999; 458 Walle (CR10) 2004; 36 Hollman (CR25) 1997; 418 Morand, Manach, Crespy, Remesy (CR29) 2000; 33 Menendez (CR19) 2011; 55 Lee, Mitchell (CR28) 2012; 18 Duarte (CR2) 2001; 133 Petri (CR11) 2003; 31 Kwon (CR27) 2007; 337 Yeh, Lin, Lin, Li, Chuang (CR30) 2016; 55 Manach (CR17) 1998; 426 Sun, Simonyi, Sun (CR1) 2002; 32 Satue-Gracia, Andres-Lacueva, Lamuela-Raventos, Frankel (CR5) 1999; 47 Xing, Chen, Zhong (CR26) 2005; 78 Chen (CR24) 2012; 1227 Terao (CR21) 2001; 35 Ohara (CR35) 2013; 441 Murota, Shimizu, Chujo, Moon, Terao (CR13) 2000; 384 Russo, Spagnuolo, Tedesco, Bilotto, Russo (CR4) 2012; 83 Mullen, Edwards, Crozier (CR22) 2006; 96 Day, Bao, Morgan, Williamson (CR16) 2000; 29 Ishisaka, Mukai, Terao, Shibata, Kawai (CR34) 2014; 557 Pasinetti (CR33) 2013; 27 Kroon (CR32) 2004; 80 Guo (CR18) 2013; 57 Y Kashiwada (BFsrep35460_CR7) 2005; 13 JPE Spencer (BFsrep35460_CR14) 1999; 458 K Ohara (BFsrep35460_CR35) 2013; 441 S Chen (BFsrep35460_CR23) 2012; 724 J Lee (BFsrep35460_CR28) 2012; 18 GM Kitanov (BFsrep35460_CR6) 1988; 24 GW Plumb (BFsrep35460_CR8) 1999; 4 PCH Hollman (BFsrep35460_CR25) 1997; 418 C Manach (BFsrep35460_CR17) 1998; 426 M Shirai (BFsrep35460_CR9) 2001; 49 J Xing (BFsrep35460_CR26) 2005; 78 MT Satue-Gracia (BFsrep35460_CR5) 1999; 47 ALA Sesink (BFsrep35460_CR15) 2001; 131 SL Yeh (BFsrep35460_CR30) 2016; 55 M Russo (BFsrep35460_CR4) 2012; 83 C Menendez (BFsrep35460_CR19) 2011; 55 XD Guo (BFsrep35460_CR18) 2013; 57 BFsrep35460_CR36 JH Moon (BFsrep35460_CR20) 2001; 30 T Walle (BFsrep35460_CR10) 2004; 36 AJ Day (BFsrep35460_CR12) 2003; 65 C Morand (BFsrep35460_CR29) 2000; 33 AY Sun (BFsrep35460_CR1) 2002; 32 SH Kwon (BFsrep35460_CR27) 2007; 337 J Duarte (BFsrep35460_CR2) 2001; 133 K Ishizawa (BFsrep35460_CR3) 2011; 115 GM Pasinetti (BFsrep35460_CR33) 2013; 27 A Ishisaka (BFsrep35460_CR34) 2014; 557 S Chen (BFsrep35460_CR24) 2012; 1227 N Petri (BFsrep35460_CR11) 2003; 31 AJ Day (BFsrep35460_CR16) 2000; 29 C Manach (BFsrep35460_CR31) 1997; 409 PA Kroon (BFsrep35460_CR32) 2004; 80 J Terao (BFsrep35460_CR21) 2001; 35 W Mullen (BFsrep35460_CR22) 2006; 96 K Murota (BFsrep35460_CR13) 2000; 384 23097297 - FASEB J. 2013 Feb;27(2):769-81 24216107 - Biochem Biophys Res Commun. 2013 Nov 29;441(4):929-34 23504962 - Mol Nutr Food Res. 2013 Jun;57(6):1037-45 10481070 - FEBS Lett. 1999 Sep 17;458(2):224-30 15213022 - Am J Clin Nutr. 2004 Jul;80(1):15-21 10794609 - J Agric Food Chem. 1999 Jun;47(6):2198-202 11118813 - Free Radic Biol Med. 2000 Dec 15;29(12):1234-43 22483220 - Anal Chim Acta. 2012 Apr 29;724:127-35 11811543 - Free Radic Res. 2001 Dec;35(6):925-31 12663055 - Biochem Pharmacol. 2003 Apr 1;65(7):1199-206 9600261 - FEBS Lett. 1998 Apr 24;426(3):331-6 21436601 - J Pharmacol Sci. 2011;115(4):466-70 11435510 - J Nutr. 2001 Jul;131(7):1938-41 12756216 - Drug Metab Dispos. 2003 Jun;31(6):805-13 22439822 - J Agric Food Chem. 2012 Apr 18;60(15):3874-81 24893148 - Arch Biochem Biophys. 2014 Sep 1;557:11-7 15598565 - Bioorg Med Chem. 2005 Jan 17;13(2):443-8 9414116 - FEBS Lett. 1997 Nov 24;418(1-2):152-6 16107266 - Life Sci. 2005 Nov 26;78(2):140-6 25691233 - Eur J Nutr. 2016 Feb;55(1):413-22 15019968 - Free Radic Biol Med. 2004 Apr 1;36(7):829-37 10496415 - Redox Rep. 1999;4(3):123-7 9199494 - FEBS Lett. 1997 Jun 2;409(1):12-6 11325801 - Br J Pharmacol. 2001 May;133(1):117-24 11200097 - Free Radic Res. 2000 Nov;33(5):667-76 22265782 - J Chromatogr A. 2012 Mar 2;1227:145-53 11841921 - Free Radic Biol Med. 2002 Feb 15;32(4):314-8 11714366 - J Agric Food Chem. 2001 Nov;49(11):5602-8 11368329 - Arch Biochem Biophys. 2000 Dec 15;384(2):391-7 17280808 - Int J Pharm. 2007 Jun 7;337(1-2):148-54 16869998 - Br J Nutr. 2006 Jul;96(1):107-16 22144045 - Mol Nutr Food Res. 2011 Dec;55(12):1780-90 21856292 - Biochem Pharmacol. 2012 Jan 1;83(1):6-15 11368925 - Free Radic Biol Med. 2001 Jun 1;30(11):1274-85 |
| References_xml | – volume: 115 start-page: 466 year: 2011 end-page: 470 ident: CR3 article-title: Metabolism of quercetin and its protective effect against Arteriosclerosis publication-title: J Pharmacol Sci doi: 10.1254/jphs.10R38FM – volume: 47 start-page: 2198 year: 1999 end-page: 2202 ident: CR5 article-title: Spanish sparkling wines (cavas) as inhibitors of human low-density lipoprotein oxidation publication-title: J Agric Food Chem doi: 10.1021/jf9808527 – volume: 557 start-page: 11 year: 2014 end-page: 17 ident: CR34 article-title: Specific localization of quercetin-3-O-glucuronide in human brain publication-title: Arch Biochem Biophys doi: 10.1016/j.abb.2014.05.025 – volume: 36 start-page: 829 year: 2004 end-page: 837 ident: CR10 article-title: Absorption and metabolism of flavonoids publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2004.01.002 – volume: 4 start-page: 123 year: 1999 end-page: 127 ident: CR8 article-title: Antioxidant properties of flavonol glycosides from green beans publication-title: Redox Rep doi: 10.1179/135100099101534800 – volume: 458 start-page: 224 year: 1999 end-page: 230 ident: CR14 article-title: The small intestine can both absorb and glucuronidate luminal flavonoids publication-title: Febs Lett doi: 10.1016/S0014-5793(99)01160-6 – volume: 24 start-page: 119 year: 1988 end-page: 120 ident: CR6 article-title: Miquelianin and other polyphenols from Hypericum hirsutum publication-title: Chem Nat Compd doi: 10.1007/BF00597593 – volume: 30 start-page: 1274 year: 2001 end-page: 1285 ident: CR20 article-title: Identification of quercetin 3-O-beta-D-glucuronide as an antioxidative metabolite in rat plasma after oral administration of quercetin publication-title: Free Radical Bio Med doi: 10.1016/S0891-5849(01)00522-6 – volume: 384 start-page: 391 year: 2000 end-page: 397 ident: CR13 article-title: Efficiency of absorption and metabolic conversion of quercetin and its glucosides in human intestinal cell line Caco-2 publication-title: Arch Biochem Biophys doi: 10.1006/abbi.2000.2123 – volume: 57 start-page: 1037 year: 2013 end-page: 1045 ident: CR18 article-title: Quercetin and quercetin-3-O-glucuronide are equally effective in ameliorating endothelial insulin resistance through inhibition of reactive oxygen species-associated inflammation publication-title: Mol Nutr Food Res doi: 10.1002/mnfr.201200569 – volume: 35 start-page: 925 year: 2001 end-page: 931 ident: CR21 article-title: Protection by quercetin and quercetin 3-O-beta-glueuronide of peroxynitrite-induced antioxidant consumption in human plasma low-density lipoprotein publication-title: Free Radic Res doi: 10.1080/10715760100301421 – volume: 418 start-page: 152 year: 1997 end-page: 156 ident: CR25 article-title: Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man publication-title: Febs Lett doi: 10.1016/S0014-5793(97)01367-7 – volume: 83 start-page: 6 year: 2012 end-page: 15 ident: CR4 article-title: The flavonoid quercetin in disease prevention and therapy: Facts and fancies publication-title: Biochem Pharmacol doi: 10.1016/j.bcp.2011.08.010 – volume: 78 start-page: 140 year: 2005 end-page: 146 ident: CR26 article-title: Absorption and enterohepatic circulation of baicalin in rats publication-title: Life Sci doi: 10.1016/j.lfs.2005.04.072 – volume: 29 start-page: 1234 year: 2000 end-page: 1243 ident: CR16 article-title: Conjugation position of quercetin glucuronides and effect on biological activity publication-title: Free Radical Bio Med doi: 10.1016/S0891-5849(00)00416-0 – volume: 13 start-page: 443 year: 2005 end-page: 448 ident: CR7 article-title: Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations with related alkaloids publication-title: Bioorg Med Chem doi: 10.1016/j.bmc.2004.10.020 – volume: 96 start-page: 107 year: 2006 end-page: 116 ident: CR22 article-title: Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions publication-title: Brit J Nutr doi: 10.1079/BJN20061809 – volume: 409 start-page: 12 year: 1997 end-page: 16 ident: CR31 article-title: Bioavailability of rutin and quercetin in rats publication-title: Febs Letters doi: 10.1016/S0014-5793(97)00467-5 – volume: 55 start-page: 1780 year: 2011 end-page: 1790 ident: CR19 article-title: Vascular deconjugation of quercetin glucuronide: the flavonoid paradox revealed? publication-title: Mol Nutr Food Res doi: 10.1002/mnfr.201100378 – volume: 49 start-page: 5602 year: 2001 end-page: 5608 ident: CR9 article-title: Inhibitory effect of a quercetin metabolite, quercetin 3-O-beta-D-glucuronide, on lipid peroxidation in liposomal membranes publication-title: J Agric Food Chem doi: 10.1021/jf010713g – volume: 131 start-page: 1938 year: 2001 end-page: 1941 ident: CR15 article-title: Quercetin gluouronides but not glucosides are present in human plasma after consumption of quercetin-3-glucoside or quercetin-4 ‘-glucoside publication-title: J Nutr doi: 10.1093/jn/131.7.1938 – volume: 441 start-page: 929 year: 2013 end-page: 934 ident: CR35 article-title: Quercetin-3-O-glucuronide induces ABCA1 expression by LXR alpha activation in murine macrophages publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2013.10.168 – volume: 80 start-page: 15 year: 2004 end-page: 21 ident: CR32 article-title: How should we assess the effects of exposure to dietary polyphenols ? publication-title: Am. J. Clin. Nutr doi: 10.1093/ajcn/80.1.15 – volume: 18 start-page: 3874 year: 2012 end-page: 3881 ident: CR28 article-title: Pharmacokinetics of quercetin absorption from apples and onions in healthy humans publication-title: J Agric Food Chem doi: 10.1021/jf3001857 – volume: 337 start-page: 148 year: 2007 end-page: 154 ident: CR27 article-title: Comparison of oral bioavailability of genistein and genistin in rats publication-title: International J Pharm doi: 10.1016/j.ijpharm.2006.12.046 – volume: 133 start-page: 117 year: 2001 end-page: 124 ident: CR2 article-title: Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats publication-title: Br J Pharmacol doi: 10.1038/sj.bjp.0704064 – volume: 31 start-page: 805 year: 2003 end-page: 813 ident: CR11 article-title: Absorption/metabolism of sulforaphane and quercetin, and regulation of phase II enzymes, in human jejunum publication-title: Drug Metab Dispos doi: 10.1124/dmd.31.6.805 – volume: 724 start-page: 127 year: 2012 end-page: 135 ident: CR23 article-title: Simultaneous qualitative assessment and quantitative analysis of flavonoids in various tissues of lotus (Nelumbo nucifera) using high performance liquid chromatography coupled with triple quad mass spectrometry publication-title: Anal Chim Acta doi: 10.1016/j.aca.2012.02.051 – volume: 33 start-page: 667 year: 2000 end-page: 676 ident: CR29 article-title: Quercetin 3-O-beta-glucoside is better absorbed than other quercetin forms and is not present in rat plasma publication-title: Free Radic Res doi: 10.1080/10715760000301181 – volume: 65 start-page: 1199 year: 2003 end-page: 1206 ident: CR12 article-title: Absorption of quercetin-3-glucoside and quercetin-4 ‘-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter publication-title: Biochem Pharmacol doi: 10.1016/S0006-2952(03)00039-X – volume: 55 start-page: 413 year: 2016 end-page: 422 ident: CR30 article-title: Comparing the metabolism of quercetin in rats, mice and gerbils publication-title: Eur J Nutr doi: 10.1007/s00394-015-0862-9 – volume: 27 start-page: 769 year: 2013 end-page: 781 ident: CR33 article-title: Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer’s disease publication-title: FASEB J doi: 10.1096/fj.12-212118 – ident: CR36 – volume: 1227 start-page: 145 year: 2012 end-page: 153 ident: CR24 article-title: Analysis of flavonoids from lotus (Nelumbo nucifera) leaves using high performance liquid chromatography/photodiode array detector tandem electrospray ionization mass spectrometry and an extraction method optimized by orthogonal design publication-title: J Chromatogr A doi: 10.1016/j.chroma.2011.12.098 – volume: 32 start-page: 314 year: 2002 end-page: 318 ident: CR1 article-title: The “French Paradox” and beyond: neuroprotective effects of polyphenols publication-title: Free Radic Biol Med doi: 10.1016/S0891-5849(01)00803-6 – volume: 426 start-page: 331 year: 1998 end-page: 336 ident: CR17 article-title: Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties publication-title: Febs Lett doi: 10.1016/S0014-5793(98)00367-6 – volume: 55 start-page: 413 year: 2016 ident: BFsrep35460_CR30 publication-title: Eur J Nutr doi: 10.1007/s00394-015-0862-9 – volume: 115 start-page: 466 year: 2011 ident: BFsrep35460_CR3 publication-title: J Pharmacol Sci doi: 10.1254/jphs.10R38FM – volume: 49 start-page: 5602 year: 2001 ident: BFsrep35460_CR9 publication-title: J Agric Food Chem doi: 10.1021/jf010713g – volume: 557 start-page: 11 year: 2014 ident: BFsrep35460_CR34 publication-title: Arch Biochem Biophys doi: 10.1016/j.abb.2014.05.025 – volume: 24 start-page: 119 year: 1988 ident: BFsrep35460_CR6 publication-title: Chem Nat Compd doi: 10.1007/BF00597593 – volume: 18 start-page: 3874 year: 2012 ident: BFsrep35460_CR28 publication-title: J Agric Food Chem doi: 10.1021/jf3001857 – volume: 13 start-page: 443 year: 2005 ident: BFsrep35460_CR7 publication-title: Bioorg Med Chem doi: 10.1016/j.bmc.2004.10.020 – volume: 4 start-page: 123 year: 1999 ident: BFsrep35460_CR8 publication-title: Redox Rep doi: 10.1179/135100099101534800 – volume: 133 start-page: 117 year: 2001 ident: BFsrep35460_CR2 publication-title: Br J Pharmacol doi: 10.1038/sj.bjp.0704064 – volume: 29 start-page: 1234 year: 2000 ident: BFsrep35460_CR16 publication-title: Free Radical Bio Med doi: 10.1016/S0891-5849(00)00416-0 – volume: 131 start-page: 1938 year: 2001 ident: BFsrep35460_CR15 publication-title: J Nutr doi: 10.1093/jn/131.7.1938 – volume: 32 start-page: 314 year: 2002 ident: BFsrep35460_CR1 publication-title: Free Radic Biol Med doi: 10.1016/S0891-5849(01)00803-6 – volume: 1227 start-page: 145 year: 2012 ident: BFsrep35460_CR24 publication-title: J Chromatogr A doi: 10.1016/j.chroma.2011.12.098 – volume: 31 start-page: 805 year: 2003 ident: BFsrep35460_CR11 publication-title: Drug Metab Dispos doi: 10.1124/dmd.31.6.805 – volume: 78 start-page: 140 year: 2005 ident: BFsrep35460_CR26 publication-title: Life Sci doi: 10.1016/j.lfs.2005.04.072 – volume: 418 start-page: 152 year: 1997 ident: BFsrep35460_CR25 publication-title: Febs Lett doi: 10.1016/S0014-5793(97)01367-7 – volume: 458 start-page: 224 year: 1999 ident: BFsrep35460_CR14 publication-title: Febs Lett doi: 10.1016/S0014-5793(99)01160-6 – volume: 30 start-page: 1274 year: 2001 ident: BFsrep35460_CR20 publication-title: Free Radical Bio Med doi: 10.1016/S0891-5849(01)00522-6 – volume: 33 start-page: 667 year: 2000 ident: BFsrep35460_CR29 publication-title: Free Radic Res doi: 10.1080/10715760000301181 – volume: 65 start-page: 1199 year: 2003 ident: BFsrep35460_CR12 publication-title: Biochem Pharmacol doi: 10.1016/S0006-2952(03)00039-X – volume: 96 start-page: 107 year: 2006 ident: BFsrep35460_CR22 publication-title: Brit J Nutr doi: 10.1079/BJN20061809 – ident: BFsrep35460_CR36 – volume: 36 start-page: 829 year: 2004 ident: BFsrep35460_CR10 publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2004.01.002 – volume: 35 start-page: 925 year: 2001 ident: BFsrep35460_CR21 publication-title: Free Radic Res doi: 10.1080/10715760100301421 – volume: 27 start-page: 769 year: 2013 ident: BFsrep35460_CR33 publication-title: FASEB J doi: 10.1096/fj.12-212118 – volume: 426 start-page: 331 year: 1998 ident: BFsrep35460_CR17 publication-title: Febs Lett doi: 10.1016/S0014-5793(98)00367-6 – volume: 57 start-page: 1037 year: 2013 ident: BFsrep35460_CR18 publication-title: Mol Nutr Food Res doi: 10.1002/mnfr.201200569 – volume: 80 start-page: 15 year: 2004 ident: BFsrep35460_CR32 publication-title: Am. J. Clin. Nutr doi: 10.1093/ajcn/80.1.15 – volume: 441 start-page: 929 year: 2013 ident: BFsrep35460_CR35 publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2013.10.168 – volume: 409 start-page: 12 year: 1997 ident: BFsrep35460_CR31 publication-title: Febs Letters doi: 10.1016/S0014-5793(97)00467-5 – volume: 724 start-page: 127 year: 2012 ident: BFsrep35460_CR23 publication-title: Anal Chim Acta doi: 10.1016/j.aca.2012.02.051 – volume: 384 start-page: 391 year: 2000 ident: BFsrep35460_CR13 publication-title: Arch Biochem Biophys doi: 10.1006/abbi.2000.2123 – volume: 83 start-page: 6 year: 2012 ident: BFsrep35460_CR4 publication-title: Biochem Pharmacol doi: 10.1016/j.bcp.2011.08.010 – volume: 47 start-page: 2198 year: 1999 ident: BFsrep35460_CR5 publication-title: J Agric Food Chem doi: 10.1021/jf9808527 – volume: 337 start-page: 148 year: 2007 ident: BFsrep35460_CR27 publication-title: International J Pharm doi: 10.1016/j.ijpharm.2006.12.046 – volume: 55 start-page: 1780 year: 2011 ident: BFsrep35460_CR19 publication-title: Mol Nutr Food Res doi: 10.1002/mnfr.201100378 – reference: 16869998 - Br J Nutr. 2006 Jul;96(1):107-16 – reference: 10481070 - FEBS Lett. 1999 Sep 17;458(2):224-30 – reference: 9199494 - FEBS Lett. 1997 Jun 2;409(1):12-6 – reference: 24893148 - Arch Biochem Biophys. 2014 Sep 1;557:11-7 – reference: 11368329 - Arch Biochem Biophys. 2000 Dec 15;384(2):391-7 – reference: 12756216 - Drug Metab Dispos. 2003 Jun;31(6):805-13 – reference: 21856292 - Biochem Pharmacol. 2012 Jan 1;83(1):6-15 – reference: 10794609 - J Agric Food Chem. 1999 Jun;47(6):2198-202 – reference: 11841921 - Free Radic Biol Med. 2002 Feb 15;32(4):314-8 – reference: 15213022 - Am J Clin Nutr. 2004 Jul;80(1):15-21 – reference: 25691233 - Eur J Nutr. 2016 Feb;55(1):413-22 – reference: 22144045 - Mol Nutr Food Res. 2011 Dec;55(12):1780-90 – reference: 11811543 - Free Radic Res. 2001 Dec;35(6):925-31 – reference: 10496415 - Redox Rep. 1999;4(3):123-7 – reference: 15598565 - Bioorg Med Chem. 2005 Jan 17;13(2):443-8 – reference: 21436601 - J Pharmacol Sci. 2011;115(4):466-70 – reference: 23097297 - FASEB J. 2013 Feb;27(2):769-81 – reference: 9414116 - FEBS Lett. 1997 Nov 24;418(1-2):152-6 – reference: 24216107 - Biochem Biophys Res Commun. 2013 Nov 29;441(4):929-34 – reference: 12663055 - Biochem Pharmacol. 2003 Apr 1;65(7):1199-206 – reference: 11368925 - Free Radic Biol Med. 2001 Jun 1;30(11):1274-85 – reference: 22439822 - J Agric Food Chem. 2012 Apr 18;60(15):3874-81 – reference: 11118813 - Free Radic Biol Med. 2000 Dec 15;29(12):1234-43 – reference: 9600261 - FEBS Lett. 1998 Apr 24;426(3):331-6 – reference: 15019968 - Free Radic Biol Med. 2004 Apr 1;36(7):829-37 – reference: 16107266 - Life Sci. 2005 Nov 26;78(2):140-6 – reference: 22265782 - J Chromatogr A. 2012 Mar 2;1227:145-53 – reference: 11325801 - Br J Pharmacol. 2001 May;133(1):117-24 – reference: 23504962 - Mol Nutr Food Res. 2013 Jun;57(6):1037-45 – reference: 11200097 - Free Radic Res. 2000 Nov;33(5):667-76 – reference: 17280808 - Int J Pharm. 2007 Jun 7;337(1-2):148-54 – reference: 22483220 - Anal Chim Acta. 2012 Apr 29;724:127-35 – reference: 11714366 - J Agric Food Chem. 2001 Nov;49(11):5602-8 – reference: 11435510 - J Nutr. 2001 Jul;131(7):1938-41 |
| SSID | ssj0000529419 |
| Score | 2.4609075 |
| Snippet | Quercetin is a natural flavonoid widely distributed in human diet and functional foods. Quercetin 3-
O
-
β
-glucuronide (Q3G) is present in wine and some... Quercetin is a natural flavonoid widely distributed in human diet and functional foods. Quercetin 3-O-β-glucuronide (Q3G) is present in wine and some medicinal... |
| SourceID | pubmedcentral pubmed crossref springer |
| SourceType | Open Access Repository Index Database Enrichment Source Publisher |
| StartPage | 35460 |
| SubjectTerms | 140/131 631/1647/296 631/92/349 639/638/11 Administration, Oral Animals Chromatography, High Pressure Liquid - methods Humanities and Social Sciences Injections, Intravenous Male multidisciplinary Quercetin - administration & dosage Quercetin - analogs & derivatives Quercetin - blood Quercetin - chemistry Quercetin - pharmacokinetics Rats, Sprague-Dawley Reproducibility of Results Science Tandem Mass Spectrometry - methods Tissue Distribution |
| SummonAdditionalLinks | – databaseName: SpringerOpen Free (Free internet resource, activated by CARLI) dbid: C6C link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3LSsQwFA0yIrgR39YXQV24CdNH-shSisMgjg6MA7MrzQtFqcM8FvNbfojf5E2bVmd04abQ9pSG3DT33ObmXISumAfN04FPmJtLQnM4JGZzjjByUJGCGbDc9d57iLpDejcKR1YsemrTKitJy3KarrPD2uAvxkFII4jO141iuxnMaZQ2v1PMghX1WK0dFCTfTyx5nMbNrKZArqyDlu6ls422LC_EN1VLdtCaKnbRRlUpcrGHZN9KTL8CKwQIFk39QGxTrTDM8BNhdjDjvJA_zgLySD4_yuT0uVHClQrDVbD8FPMFHnb79ynpDdq9wT4adm6f0i6xBRKIoJ47IyFXOuFUca1FpF0BzobHuQTKIJlROYXQTgRGQEwkIuY8kZoDLId42A8VYzQ4QK3ivVBHCIee0rGQ0lehokLqnHkh95Xmbp5TxhMHXdedmAmrHm6KWLxl5Sp2kGRNfzvoooGOK8mMv0CHlQEaiB_Hhr1QB8VLpmkARgh7-U7x8lwKYgOnDWPmO-iyNmJmv8Tp7zcf_wt1gjaBGkXGS_n0FLVmk7k6A_ox4-flwPsCV1Xe-Q priority: 102 providerName: Springer Nature |
| Title | Pharmacokinetic comparison between quercetin and quercetin 3-O-β-glucuronide in rats by UHPLC-MS/MS |
| URI | https://link.springer.com/article/10.1038/srep35460 https://www.ncbi.nlm.nih.gov/pubmed/27775094 https://pubmed.ncbi.nlm.nih.gov/PMC5075792 |
| Volume | 6 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1LSwMxEB58IHgR39ZHCerBS7TNZh85iNSilGK1WAveyuaFoqxaK9i_5Q_xNznZF1Y9eNlld2fZkEn2-4ZkvgHYF3VsnvUYFbVYUx7jIXLJOcrJQQUG_4Bp1nvnMmj1efvWv52CosZm3oGvf4Z2rp5Uf_h4-P4yPsEJf5yljEdHiCXPns8DjNxnEZBCNz87OcvPJL6Z4GmJD6e9TpFDsEJj6PvbE8hUwtHPrZI_1ktTGDpfhIWcP5JG5vAlmDLJMsxlFSXHK6C7uRT1A7JHNCGqrDNI8i1ZBJFgqFymM4kT_e3Ko1f08yPdxP7mFHO1IXgXR8grkWPSb3UvmrTTO-r0VqF_fnbTbNG8kAJVvF4bUV8aG0lupLUqsDWFoCTDWCO10MKpoWIIqDwnNKYiFUoZaSvRLMa4mflGCO6twUzylJgNIH7d2FBpzYxvuNI2FnVfMmNlLY65kFEFDopOHKhcZdwVu3gcpKvdXjQo-7sCu6Xpcyat8ZfReuaA0oSFoWM5vALhhGtKAyeYPfkkub9LhbOR-_qhYBXYK5w4KAbc7y9v_qd5WzCPDCpwYMb4NsyMhm9mB1nKSFZhttFo99p4Pj277F5XYboZNKtpzF9Nx-cXsi_u8Q |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3JTsMwELUQCMEFsRNWCzhwidokzuIjiqgCNKVSW6m3KN4EAoWqy6G_xYfwTYyzQQsHLpGSvCiWJ_G8scdvELqmFjRPObZJm6kwSQqHQG_O4VoOypMwAua73uOOFw3Iw9AdlmLRkzKtspC0zIfpKjusAf5i5LjEg-h8DSi2p7O3Qi-sp1P0ghWxaKUd5ATfTyx4nNrNLKdALq2D5u6ltY22Sl6Ib4uW7KAVme2i9aJS5HwPiW4pMf0KrBAgmNf1A3GZaoVhhB9zvYMZp5n4ceaYT-bnR56cPtNKuEJiuAqWn2A2x4Oo2w7NuNeIe_to0Lrrh5FZFkgwObGaU9NlUgWMSKYU91STg7NhfiqAMgiqVU4htOOOFhDjAfcZC4RiAEshHrZdSSlxDtBq9p7JI4RdSyqfC2FLVxIuVEotl9lSsWaaEsoCA91UnZjwUj1cF7F4S_JVbCdI6v420GUNHRWSGX-BDgsD1BDb9zV7IQbyF0xTA7QQ9uKd7OU5F8QGTuv61DbQVWXEpPwTJ7_ffPwv1AXaiPpxO2nfdx5P0CbQJE97LJucotXpeCbPgIpM2Xn-EX4B-qnh6A |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3JTsMwEB1BEYgLYiesFnDgEprFWXxEhaoshUqlUm9RvAkEChVtD_wWH8I3MU7SQIEDl0hJXhTL43ie45k3AMfMxeZp37OZk0qbpniITXKOMHJQocIZMM96b9-GrR696gf9Mll9WIZVFpKW-TQ9iQ6ro78Y-AENndOB1LMwhzTbMWutRtiofqmYTSvqsol-kB9_PTXldSpX8zMM8sdeaO5imsuwVHJDcla0ZgVmVLYK80W1yLc1kJ1SZvoJmSFCiKhqCJIy3IrgLP8qTBYzSTP57cy37-yP9zxAfWzUcKUieBWtPyT8jfRanZuG3e7W29116DUv7hstuyySYAvqOiM74ErHnCqutQi1I9Dh8CiVSBskM0qnuLwTvhERE7GIOI-l5ghLcU3sBYox6m9ALXvJ1BaQwFU6ElJ6KlBUSJ0yN-Ce0txJU8p4bMHJpBMTUSqIm0IWz0m-k-3HSdXfFhxW0EEhm_EXaLMwQAXxosgwGGpBNGWaCmDEsKfvZI8PuSg2DocgYp4FRxMjJuXXOPz95u1_oQ5goXPeTG4ub693YBGZUmiclkd3oTZ6Has9ZCMjvp-PwU8aJeLx |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Pharmacokinetic+comparison+between+quercetin+and+quercetin+3-O-%CE%B2-glucuronide+in+rats+by+UHPLC-MS%2FMS&rft.jtitle=Scientific+reports&rft.au=Yang%2C+Le-Le&rft.au=Xiao%2C+Na&rft.au=Li%2C+Xiao-Wei&rft.au=Fan%2C+Yong&rft.date=2016-10-24&rft.issn=2045-2322&rft.eissn=2045-2322&rft.volume=6&rft.issue=1&rft_id=info:doi/10.1038%2Fsrep35460&rft.externalDBID=n%2Fa&rft.externalDocID=10_1038_srep35460 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon |