Inhibition of Brain Epidermal Growth Factor Receptor Activation: A Novel Target in Neurodegenerative Diseases and Brain Injuries
Several reports have been published recently demonstrating a beneficial effect of epidermal growth factor receptor (EGFR) inhibitors in improving pathologic and behavioral conditions in neurodegenerative diseases (NDDs) such as Alzheimer’s disease and Amyotrophic Lateral Sclerosis (ALS) as well as t...
Saved in:
| Published in | Molecular pharmacology Vol. 98; no. 1; pp. 13 - 22 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.07.2020
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Several reports have been published recently demonstrating a beneficial effect of epidermal growth factor receptor (EGFR) inhibitors in improving pathologic and behavioral conditions in neurodegenerative diseases (NDDs) such as Alzheimer’s disease and Amyotrophic Lateral Sclerosis (ALS) as well as the brain and spinal cord injuries (SCI). Despite successful therapeutic effects of EGFR inhibition in these pathologic conditions, there is still no report of proof-of-concept studies in well-characterized animal models using recently developed blood-brain barrier (BBB)-penetrating EGFR inhibitors, which is due to previous conflicting reports concerning the level of EGFR or activated EGFR in normal and pathologic conditions that caused target engagement to be a concern in any future EGFR inhibition therapy. In this review, the level of EGFR expression and activation in the developing central nervous system (CNS) compared with the adult CNS will be explained as well as how neuronal injury or pathologic conditions, especially inflammation and amyloid fibrils, induce reactive astrocytes leading to an increase in the expression and activation of EGFR and, finally, neurodegeneration. Furthermore, in this review, we will discuss two main molecular mechanisms that can be proposed as the neuroprotective effects of EGFR inhibition in these pathologic conditions. We will also review the recent advances in the development of BBB-penetrating EGFR inhibitors in cancer therapy, which may eventually be repositioned for NDDs and SCI therapy in the future.
Based on the lessons from the applications of EGFR inhibitors in oncology, it is concluded that EGFR inhibitors can be beneficial in treatment of neurodegenerative diseases and spinal cord injuries. They carry their therapeutic potentials through induction of autophagy and attenuation of reactive astrocytes.
▪ |
|---|---|
| AbstractList | Several reports have been published recently demonstrating a beneficial effect of epidermal growth factor receptor (EGFR) inhibitors in improving pathologic and behavioral conditions in neurodegenerative diseases (NDDs) such as Alzheimer's disease and Amyotrophic Lateral Sclerosis (ALS) as well as the brain and spinal cord injuries (SCI). Despite successful therapeutic effects of EGFR inhibition in these pathologic conditions, there is still no report of proof-of-concept studies in well-characterized animal models using recently developed blood-brain barrier (BBB)-penetrating EGFR inhibitors, which is due to previous conflicting reports concerning the level of EGFR or activated EGFR in normal and pathologic conditions that caused target engagement to be a concern in any future EGFR inhibition therapy. In this review, the level of EGFR expression and activation in the developing central nervous system (CNS) compared with the adult CNS will be explained as well as how neuronal injury or pathologic conditions, especially inflammation and amyloid fibrils, induce reactive astrocytes leading to an increase in the expression and activation of EGFR and, finally, neurodegeneration. Furthermore, in this review, we will discuss two main molecular mechanisms that can be proposed as the neuroprotective effects of EGFR inhibition in these pathologic conditions. We will also review the recent advances in the development of BBB-penetrating EGFR inhibitors in cancer therapy, which may eventually be repositioned for NDDs and SCI therapy in the future. SIGNIFICANCE STATEMENT: Based on the lessons from the applications of EGFR inhibitors in oncology, it is concluded that EGFR inhibitors can be beneficial in treatment of neurodegenerative diseases and spinal cord injuries. They carry their therapeutic potentials through induction of autophagy and attenuation of reactive astrocytes. Several reports have been published recently demonstrating a beneficial effect of epidermal growth factor receptor (EGFR) inhibitors in improving pathologic and behavioral conditions in neurodegenerative diseases (NDDs) such as Alzheimer's disease and Amyotrophic Lateral Sclerosis (ALS) as well as the brain and spinal cord injuries (SCI). Despite successful therapeutic effects of EGFR inhibition in these pathologic conditions, there is still no report of proof-of-concept studies in well-characterized animal models using recently developed blood-brain barrier (BBB)-penetrating EGFR inhibitors, which is due to previous conflicting reports concerning the level of EGFR or activated EGFR in normal and pathologic conditions that caused target engagement to be a concern in any future EGFR inhibition therapy. In this review, the level of EGFR expression and activation in the developing central nervous system (CNS) compared with the adult CNS will be explained as well as how neuronal injury or pathologic conditions, especially inflammation and amyloid fibrils, induce reactive astrocytes leading to an increase in the expression and activation of EGFR and, finally, neurodegeneration. Furthermore, in this review, we will discuss two main molecular mechanisms that can be proposed as the neuroprotective effects of EGFR inhibition in these pathologic conditions. We will also review the recent advances in the development of BBB-penetrating EGFR inhibitors in cancer therapy, which may eventually be repositioned for NDDs and SCI therapy in the future. SIGNIFICANCE STATEMENT: Based on the lessons from the applications of EGFR inhibitors in oncology, it is concluded that EGFR inhibitors can be beneficial in treatment of neurodegenerative diseases and spinal cord injuries. They carry their therapeutic potentials through induction of autophagy and attenuation of reactive astrocytes.Several reports have been published recently demonstrating a beneficial effect of epidermal growth factor receptor (EGFR) inhibitors in improving pathologic and behavioral conditions in neurodegenerative diseases (NDDs) such as Alzheimer's disease and Amyotrophic Lateral Sclerosis (ALS) as well as the brain and spinal cord injuries (SCI). Despite successful therapeutic effects of EGFR inhibition in these pathologic conditions, there is still no report of proof-of-concept studies in well-characterized animal models using recently developed blood-brain barrier (BBB)-penetrating EGFR inhibitors, which is due to previous conflicting reports concerning the level of EGFR or activated EGFR in normal and pathologic conditions that caused target engagement to be a concern in any future EGFR inhibition therapy. In this review, the level of EGFR expression and activation in the developing central nervous system (CNS) compared with the adult CNS will be explained as well as how neuronal injury or pathologic conditions, especially inflammation and amyloid fibrils, induce reactive astrocytes leading to an increase in the expression and activation of EGFR and, finally, neurodegeneration. Furthermore, in this review, we will discuss two main molecular mechanisms that can be proposed as the neuroprotective effects of EGFR inhibition in these pathologic conditions. We will also review the recent advances in the development of BBB-penetrating EGFR inhibitors in cancer therapy, which may eventually be repositioned for NDDs and SCI therapy in the future. SIGNIFICANCE STATEMENT: Based on the lessons from the applications of EGFR inhibitors in oncology, it is concluded that EGFR inhibitors can be beneficial in treatment of neurodegenerative diseases and spinal cord injuries. They carry their therapeutic potentials through induction of autophagy and attenuation of reactive astrocytes. Several reports have been published recently demonstrating a beneficial effect of epidermal growth factor receptor (EGFR) inhibitors in improving pathologic and behavioral conditions in neurodegenerative diseases (NDDs) such as Alzheimer’s disease and Amyotrophic Lateral Sclerosis (ALS) as well as the brain and spinal cord injuries (SCI). Despite successful therapeutic effects of EGFR inhibition in these pathologic conditions, there is still no report of proof-of-concept studies in well-characterized animal models using recently developed blood-brain barrier (BBB)-penetrating EGFR inhibitors, which is due to previous conflicting reports concerning the level of EGFR or activated EGFR in normal and pathologic conditions that caused target engagement to be a concern in any future EGFR inhibition therapy. In this review, the level of EGFR expression and activation in the developing central nervous system (CNS) compared with the adult CNS will be explained as well as how neuronal injury or pathologic conditions, especially inflammation and amyloid fibrils, induce reactive astrocytes leading to an increase in the expression and activation of EGFR and, finally, neurodegeneration. Furthermore, in this review, we will discuss two main molecular mechanisms that can be proposed as the neuroprotective effects of EGFR inhibition in these pathologic conditions. We will also review the recent advances in the development of BBB-penetrating EGFR inhibitors in cancer therapy, which may eventually be repositioned for NDDs and SCI therapy in the future. Based on the lessons from the applications of EGFR inhibitors in oncology, it is concluded that EGFR inhibitors can be beneficial in treatment of neurodegenerative diseases and spinal cord injuries. They carry their therapeutic potentials through induction of autophagy and attenuation of reactive astrocytes. ▪ |
| Author | Tavassoly, Omid Tavassoly, Iman Sato, Takashi |
| Author_xml | – sequence: 1 givenname: Omid surname: Tavassoly fullname: Tavassoly, Omid – sequence: 2 givenname: Takashi surname: Sato fullname: Sato, Takashi – sequence: 3 givenname: Iman surname: Tavassoly fullname: Tavassoly, Iman email: iman.tavassoly@mssm.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32350120$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kc9PHCEUx0mjqav26tFw7GVWmBlmht621h-bGE2MTXojDDwUMwNbYLbx5p8u210vJh4IkHw-7-V93yHac94BQieUzCkt67PRD3Nabj6cE_4FzSgraUEopXtoRkjZFB1nfw7QYYzPhNCadeQrOqjKipGszdDr0j3Z3ibrHfYG_wzSOnyxshrCKAd8Ffy_9IQvpUo-4HtQsNo8FirZtdxIP_AC3_o1DPhBhkdIOOu3MAWv4REchAytAf-yEWSEiKXTux5L9zwFC_EY7Rs5RPi2u4_Q78uLh_Pr4ubuanm-uClUTUkqmOx5zzXU0HBVt2WrTW_y0aYxkpvOVIb1qoJWGlKThjMNmlMtgTYtSNJWR-j7tu4q-L8TxCRGGxUMg3TgpyjKijcdY7lZRk936NSPoMUq2FGGF_GeWgbqLaCCjzGAEcqm_3GkPNsgKBGb5Yi8HJF5sV1O1uYftPfKnwrdVoAczNpCEFFZcAq0DaCS0N5-pr4BYI-mqg |
| CitedBy_id | crossref_primary_10_18016_ksutarimdoga_vi_1490753 crossref_primary_10_4103_1673_5374_375304 crossref_primary_10_3389_fnagi_2021_716383 crossref_primary_10_4103_REGENMED_REGENMED_D_24_00020 crossref_primary_10_1126_sciadv_adn1870 crossref_primary_10_1152_ajpheart_00606_2020 crossref_primary_10_1002_cbdv_202300681 crossref_primary_10_1155_2022_4758189 crossref_primary_10_1002_mus_28291 crossref_primary_10_1016_j_expneurol_2021_113697 crossref_primary_10_1016_j_isci_2024_108839 crossref_primary_10_1016_j_neurobiolaging_2022_05_011 crossref_primary_10_1016_j_neuroscience_2021_01_025 crossref_primary_10_3390_antiox13030343 crossref_primary_10_3390_biomedicines11010228 crossref_primary_10_1016_j_ejphar_2024_176859 crossref_primary_10_1002_jcb_29830 crossref_primary_10_3389_fnagi_2024_1411320 crossref_primary_10_1186_s11658_021_00260_1 crossref_primary_10_1007_s42535_024_01042_8 crossref_primary_10_4103_1673_5374_332132 crossref_primary_10_1016_j_bmc_2022_116651 crossref_primary_10_1021_acschemneuro_1c00264 crossref_primary_10_1016_j_heliyon_2024_e33496 crossref_primary_10_3390_ijms25137168 crossref_primary_10_1007_s13311_021_01017_6 crossref_primary_10_1186_s43042_025_00660_4 crossref_primary_10_1016_j_ajhg_2021_10_009 crossref_primary_10_1016_j_jad_2025_02_053 crossref_primary_10_1038_s41598_023_27420_x crossref_primary_10_1016_j_pcorm_2024_100401 crossref_primary_10_1177_13524585241274523 crossref_primary_10_2174_1871527322666230426155432 crossref_primary_10_37349_en_2024_00033 crossref_primary_10_1063_5_0150887 crossref_primary_10_3389_fncel_2024_1369242 crossref_primary_10_3390_life11111185 crossref_primary_10_2174_0118715273321002240919102841 crossref_primary_10_1016_j_foodres_2022_111576 crossref_primary_10_1007_s12035_023_03547_w crossref_primary_10_1097_MD_0000000000035101 crossref_primary_10_1016_j_arr_2022_101791 crossref_primary_10_1016_j_jbc_2022_102564 crossref_primary_10_1515_biol_2021_0082 crossref_primary_10_1172_JCI175158 crossref_primary_10_3389_fnmol_2021_739016 |
| Cites_doi | 10.1002/psp4.29 10.1186/1471-2407-6-277 10.1126/scitranslmed.aag0976 10.1098/rsob.170228 10.1016/S0021-9258(19)38983-5 10.1007/s13238-013-3043-8 10.18632/oncotarget.7675 10.1056/NEJMe0806778 10.1093/brain/awh054 10.1111/jnc.14710 10.4161/cbt.22002 10.1089/ars.2015.6306 10.1038/sj.bjc.6601921 10.1016/j.semcdb.2013.12.011 10.1167/iovs.04-1473 10.1158/0008-5472.CAN-05-1346 10.3389/fphar.2019.00792 10.1016/j.yexcr.2011.08.021 10.1016/S1357-2725(00)00028-5 10.12659/MSM.907809 10.1097/00005072-199105000-00008 10.1177/1060028018824578 10.1038/nrd3181 10.1007/s00401-004-0834-2 10.1097/00001622-200403000-00008 10.1016/j.ctrv.2003.10.003 10.1517/13543780903305428 10.1172/JCI28656 10.1186/1742-2094-5-8 10.1016/j.phrs.2018.11.014 10.1172/JCI127492 10.1056/NEJMra0707704 10.1186/1742-2094-11-71 10.1152/ajpcell.00246.2008 10.1002/(SICI)1096-9861(19970407)380:2<243::AID-CNE7>3.0.CO;2-3 10.1523/JNEUROSCI.1037-07.2007 10.1038/nrc3081 10.1111/j.1471-4159.2011.07446.x 10.1016/j.semcdb.2014.01.005 10.1634/theoncologist.2017-0572 10.1038/ncb1750 10.1038/nrclinonc.2013.154 10.1371/journal.pmed.0020313 10.1073/pnas.0909314107 10.1158/0008-5472.CAN-19-2132 10.3390/ijms20010146 10.1186/s12974-018-1171-z 10.1016/j.neuron.2005.03.025 10.1097/00005072-198809000-00006 10.1523/JNEUROSCI.0081-05.2005 10.1007/s10571-015-0313-4 10.18632/oncotarget.21936 10.1177/1179069519829040 10.1016/S0959-8049(01)00230-1 10.1016/0006-8993(93)90028-L 10.1158/0008-5472.CAN-07-1248 10.1371/journal.pone.0062342 10.1371/journal.pone.0018691 10.1038/s41467-017-00037-1 10.1126/science.2422759 10.1523/JNEUROSCI.1067-18.2018 10.1523/JNEUROSCI.2751-04.2004 10.1002/glia.10358 10.1002/jnr.21364 10.1080/19420889.2016.1143575 10.1124/dmd.118.084210 10.1038/nrd1728 10.1186/s12944-016-0273-9 10.1002/1878-0261.12521 10.1016/j.neuint.2011.03.007 10.1038/nrm3048 10.5607/en.2018.27.2.77 10.1083/jcb.201506102 10.3389/fncel.2013.00258 10.2217/fon.14.249 10.1016/j.stemcr.2017.06.008 10.1016/j.jtbi.2019.109992 10.1016/0006-8993(94)01300-7 10.1038/sc.2013.166 10.1186/s40478-018-0606-1 10.1016/j.cell.2011.02.013 10.1038/nn.2575 10.1093/hmg/ddq212 10.1016/j.tins.2017.04.001 10.21037/tcr.2018.10.06 10.1073/pnas.1208011109 10.1007/s12539-019-00347-6 10.1042/EBC20180003 10.1517/14656566.2013.758714 10.1186/s13024-019-0314-8 10.1016/0306-4522(94)90547-9 10.3389/fnmol.2017.00427 10.1186/1742-2094-9-178 10.1200/JCO.2016.34.15_suppl.9003 10.1016/j.ijrobp.2003.11.041 10.1042/BCJ20180297 10.3389/fnagi.2018.00114 10.1002/1878-0261.12155 10.1681/ASN.2015030299 10.1111/j.1471-4159.2005.03073.x 10.1200/jco.2015.33.15_suppl.8016 10.1016/S1470-2045(12)70335-2 10.3390/molecules21121693 10.1523/JNEUROSCI.1004-06.2006 10.1007/s00401-019-02037-5 10.1016/j.cell.2013.08.015 10.1016/0169-328X(92)90241-3 10.1038/nm.3639 10.1038/celldisc.2017.44 10.1186/s13024-016-0098-z |
| ContentType | Journal Article |
| Copyright | 2020 American Society for Pharmacology and Experimental Therapeutics Copyright © 2020 by The American Society for Pharmacology and Experimental Therapeutics. |
| Copyright_xml | – notice: 2020 American Society for Pharmacology and Experimental Therapeutics – notice: Copyright © 2020 by The American Society for Pharmacology and Experimental Therapeutics. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1124/mol.120.119909 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1521-0111 |
| EndPage | 22 |
| ExternalDocumentID | 32350120 10_1124_mol_120_119909 S0026895X24010587 |
| Genre | Comparative Study Review Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- -~X .55 .GJ 0R~ 123 18M 2WC 34G 39C 4.4 53G 5RE 5VS AAJMC AALRI AAXUO ABCQX ABJNI ABSQV ACGFO ACGFS ADBBV ADCOW AENEX AERNN AFFNX AFHIN AFOSN ALMA_UNASSIGNED_HOLDINGS AYCSE BAWUL BTFSW CS3 DIK E3Z EBS EJD F5P F9R FDB GX1 H13 HH5 HZ~ IH2 INIJC K-O KQ8 L7B LSO M41 MVM N9A O9- OK1 P2P R.V R0Z RHF RHI ROL RPT TR2 UQL VXZ W8F WOQ X7M XOL YBU YHG ZGI ZXP AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| ID | FETCH-LOGICAL-c410t-5ab9b9de4e69c4727dfbfdfbdf6fa9f8f3f5bc3e7af040695ded91dae167ea073 |
| ISSN | 0026-895X 1521-0111 |
| IngestDate | Thu Jul 10 19:09:43 EDT 2025 Thu Apr 03 07:05:13 EDT 2025 Tue Aug 05 12:07:19 EDT 2025 Thu Apr 24 22:55:03 EDT 2025 Sat Feb 22 15:43:21 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | NPC NDDs BBB ALS CNS WB EGFR PS1 ZNRF1 p-EGFR PI3K SNP mTOR NSC AD IL NSCLC OGD GFAP GSK3β TNF-α CRMP2 CSPG SCI HER1 |
| Language | English |
| License | Copyright © 2020 by The American Society for Pharmacology and Experimental Therapeutics. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c410t-5ab9b9de4e69c4727dfbfdfbdf6fa9f8f3f5bc3e7af040695ded91dae167ea073 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 |
| PMID | 32350120 |
| PQID | 2396855410 |
| PQPubID | 23479 |
| PageCount | 10 |
| ParticipantIDs | proquest_miscellaneous_2396855410 pubmed_primary_32350120 crossref_citationtrail_10_1124_mol_120_119909 crossref_primary_10_1124_mol_120_119909 elsevier_sciencedirect_doi_10_1124_mol_120_119909 |
| PublicationCentury | 2000 |
| PublicationDate | July 2020 2020-07-00 20200701 |
| PublicationDateYYYYMMDD | 2020-07-01 |
| PublicationDate_xml | – month: 07 year: 2020 text: July 2020 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Molecular pharmacology |
| PublicationTitleAlternate | Mol Pharmacol |
| PublicationYear | 2020 |
| Publisher | Elsevier Inc |
| Publisher_xml | – name: Elsevier Inc |
| References | Herbst (bib41) 2004; 59 Dorvash, Farahmandnia, Mosaddeghi, Farahmandnejad, Saber, Khorraminejad-Shirazi, Azadi, Tavassoly (bib22) 2019; 483 Hanahan, Weinberg (bib40) 2011; 144 Liu, Zhao, Yin, Zhang (bib65) 2019; 10 Wei, Li, Yang, Shang, Fan, Li, Song (bib111) 2016; 21 Li, Tang, Zhang, Tang, Qu, Zhu, Li, Xie, Tian, Wang (bib60) 2011; 58 Wang, Chiang, Wu, Liang, Xie, Yao, Ma, Du, Zhong (bib107) 2012; 109 Liu, Chen, Johns, Neufeld (bib62) 2006; 26 Schilsky (bib82) 2010; 9 Fung (bib123) 2012 Karachaliou, Fernandez-Bruno, Paulina Bracht, Rosell (bib46) 2018; 8 Kjell, Pernold, Olson, Abrams (bib50) 2014; 52 Pike, Cummings, Monzavi, Cotman (bib76) 1994; 63 Wang, Her, Hu, Chen, Tung, Wu, Hsu, Lee, Jin, Hwang (bib106) 2017; 114 Birecree, Whetsell Jr., Stoscheck, King Jr., Nanney (bib7) 1988; 47 Kaser, Lakshmanan, Fisher (bib47) 1992; 16 Diniz, Matias, Araujo, Garcia, Barros-Aragão, Alves-Leon, de Souza, Foguel, Figueiredo, Braga (bib21) 2019; 150 Yang, Guo, Wang, Chen, Zhang, Cheng, Xu, Yin, Bai, Rabbie (bib115) 2016; 8 Wakatsuki, Araki (bib104) 2016; 9 Zhang, Neufeld (bib120) 2005; 46 Bose, Ozer (bib9) 2009; 18 Han (bib122) 2011; 6 Dorvash, Farahmandnia, Tavassoly (bib23) 2020; 12 Ahluwalia, Becker, Levy (bib2) 2018; 23 Chiang, Wang, Xie, Yau, Zhong (bib16) 2010; 107 Lipinski, Wu, Faden, Sarkar (bib61) 2015; 23 Lupo, Gioia, Nisi, Biagioni, Cacci (bib67) 2019; 13 Saltz, Easley, Kirkpatrick (bib80) 2006 Ciardiello, De Vita, Orditura, Tortora (bib17) 2004; 16 Ceyzériat, Ben Haim, Denizot, Pommier, Matos, Guillemaud, Palomares, Abjean, Petit, Gipchtein (bib12) 2018; 6 Lohmann, Bernis, Tachu, Ziemski, Grigoletto, Tamgüney (bib66) 2019; 138 Galvez-Contreras, Quiñones-Hinojosa, Gonzalez-Perez (bib34) 2013; 7 Wang, Liu, Xiong, Xu, Shi, Qiu, Zang, Mao, Zhuang (bib109) 2016; 27 Dhaunsi, Alsaeid, Akhtar (bib19) 2016; 15 González-Reyes, Nava-Mesa, Vargas-Sánchez, Ariza-Salamanca, Mora-Muñoz (bib36) 2017; 10 Tavassoly, Hu, Zhao, Mariottini, Boran, Chen, Li, Tolentino, Jayaraman, Goldfarb (bib96) 2019; 13 Hammoud, Burger, Lu, Feng (bib39) 2009; 296 Takeda, Nakagawa (bib91) 2019; 20 Jo, Yarishkin, Hwang, Chun, Park, Woo, Bae, Kim, Lee, Chun (bib43) 2014; 20 Kornblum, Hussain, Bronstein, Gall, Lee, Seroogy (bib54) 1997; 380 Berasain, Avila (bib6) 2014; 28 Toyoda, Komurasaki, Uchida, Takayama, Isobe, Okuyama, Hanada (bib99) 1995; 270 Overmiller, McGuinn, Roberts, Cooper, Brennan-Crispi, Deguchi, Peltonen, Wahl III, Mahoney (bib74) 2016; 7 Spencer, Riley, Matthew, Di Pasqua (bib89) 2019; 53 Chen, Wang, Zhou, Li, Wu (bib15) 2018; 24 Laug, Huang, Huerta, Huang, Sardar, Ortiz-Guzman, Carlson, Arenkiel, Kuo, Mohila (bib56) 2019; 129 Le Pichon, Dominguez, Solanoy, Ngu, Lewin-Koh, Chen, Eastham-Anderson, Watts, Scearce-Levie (bib58) 2013; 8 Forman, Lal, Zhang, Dabir, Swanson, Lee, Trojanowski (bib32) 2005; 25 Sigismund, Avanzato, Lanzetti (bib87) 2018; 12 Tavassoly, Goldfarb, Iyengar (bib95) 2018; 62 Qu, Tian, Guo, Fang, Zhang, Yu, Xie, Zhang, Lü, Wang (bib77) 2012; 9 Dunbar, Goddard (bib26) 2000; 32 Li, Li, Wang, Zhang, Wu, Mao, Shi, Wang, Wang, Zou (bib59) 2014; 11 Wei, Zou, Becker, Anderson, Sumpter, Xiao, Kinch, Koduru, Christudass, Veltri (bib112) 2013; 154 Enwere, Shingo, Gregg, Fujikawa, Ohta, Weiss (bib29) 2004; 24 Ciardiello, Tortora (bib18) 2008; 358 Koprich, Reske-Nielsen, Mithal, Isacson (bib53) 2008; 5 Wang, Zhang, Zhang, Fan, Shen, Hu, Chen (bib110) 2012; 7 Noro, Gemma, Kosaihira, Kokubo, Chen, Seike, Kataoka, Matsuda, Okano, Minegishi (bib73) 2006; 6 Joe, Choi, An, Eun, Jou, Park (bib44) 2018; 27 Yang, Wang, Huang, Qu, Zhang, Xu, Wang, Tian (bib114) 2011; 119 Yu, Boggon, Kobayashi, Jin, Ma, Dowlati, Kern, Tenen, Halmos (bib118) 2007; 67 Chavarría, Rodríguez-Bottero, Quijano, Cassina, Souza (bib13) 2018; 475 Booth, Hirst, Wade-Martins (bib8) 2017; 40 Faideau, Kim, Cormier, Gilmore, Welch, Auregan, Dufour, Guillermier, Brouillet, Hantraye (bib31) 2010; 19 Schreiber, Winkler, Derynck (bib84) 1986; 232 Moy, Kirkpatrick, Kar, Goss (bib70) 2007 Sato, Yoo, Kong, Sinha, Chandramani-Shivalingappa, Patel, Fridrikh, Nagano, Masuko, Beasley (bib81) 2019; 79 Iwakura, Piao, Mizuno, Takei, Kakita, Takahashi, Nawa (bib42) 2005; 93 Tremblay, Cookson, Civiero (bib100) 2019; 14 Tan, Li, Zhong, Hu, Gu, Xie (bib93) 2017; 8 Tan, Shi, Wang, Ding, Yuan, Sun (bib92) 2015; 11 Abjean, Haim, Sauvage, Hérard, Derbois, Petit, Gipstein, Guillermier, Gaudin, Bernier (bib1) 2018; 89 Goldberg, Kirkpatrick (bib35) 2005; 4 Bandopadhyay, Kingsbury, Cookson, Reid, Evans, Hope, Pittman, Lashley, Canet-Aviles, Miller (bib5) 2004; 127 Erschbamer, Pernold, Olson (bib30) 2007; 27 Tavassoly, Parmar, Shajahan-Haq, Clarke, Baumann, Tyson (bib97) 2015; 4 Leboulleux, Bastholt, Krause, de la Fouchardiere, Tennvall, Awada, Gómez, Bonichon, Leenhardt, Soufflet (bib57) 2012; 13 Kobayashi, Ji, Yuza, Meyerson, Wong, Tenen, Halmos (bib51) 2005; 65 Thomas, Grandis (bib98) 2004; 30 Wang, Liang, Zhong (bib108) 2013; 4 Avraham, Yarden (bib4) 2011; 12 Muhsin, Graham, Kirkpatrick (bib71) 2003 Wakatsuki, Furuno, Ohshima, Araki (bib105) 2015; 211 Vecchione, Jacobs, Normanno, Ciardiello, Tejpar (bib103) 2011; 317 Yarden (bib116) 2001; 37 El-Rayes, LoRusso (bib27) 2004; 91 Engelman, Mukohara, Zejnullahu, Lifshits, Borrás, Gale, Naumov, Yeap, Jarrell, Sun (bib28) 2006; 116 Dowell, Minna, Kirkpatrick (bib24) 2005 Zhang, Ju, Tjandra, Yeap, Owlanj, Feng (bib119) 2016; 36 Perez-Nievas, Serrano-Pozo (bib75) 2018; 10 Tripathi, Rodriguez-Muela, Klim, de Boer, Agrawal, Sandoe, Lopes, Ogliari, Williams, Shear (bib101) 2017; 9 Frost, Li (bib33) 2017; 7 Raab, Klagsbrun (bib78) 1997; 1333 Tyson, Baumann, Chen, Verdugo, Tavassoly, Wang, Weiner, Clarke (bib102) 2011; 11 Ahn, Kim, Kim, Lin, Ratnayake, Carlie, Yin, Yang, Jiang, Yang (bib3) 2016; 34 Morizawa, Hirayama, Ohno, Shibata, Shigetomi, Sui, Nabekura, Sato, Okajima, Takebayashi (bib69) 2017; 8 Shandra, Winemiller, Heithoff, Munoz-Ballester, George, Benko, Zuidhoek, Besser, Curley, Edwards III (bib86) 2019; 39 Greulich, Chen, Feng, Jänne, Alvarez, Zappaterra, Bulmer, Frank, Hahn, Sellers (bib37) 2005; 2 Tavassoly (bib94) 2015 Chen, He, Hu, Shen, Cao, Wei, Luan, He, Jiang, Tao (bib14) 2017; 3 Duffy, Collier, Patterson, Kemp, Luk, Tansey, Paumier, Kanaan, Fischer, Polinski (bib25) 2018; 15 Kim, Yang, Chen, Cheng, Yin, Martin, Yang, Jiang, Ahn (bib48) 2015; 33 Messersmith, Ahnen (bib68) 2008; 359 Söllvander, Nikitidou, Brolin, Söderberg, Sehlin, Lannfelt, Erlandsson (bib88) 2016; 11 Yu, Pao (bib117) 2013; 10 Liu, Neufeld (bib63) 2004; 46 Kahlson, Colodner (bib45) 2015; 9 Neumann, Müller, Görner, Kretzschmar, Haass, Kahle (bib72) 2004; 107 Carpenter, Cohen (bib11) 1990; 265 Kolev, Mandinova, Guinea-Viniegra, Hu, Lefort, Lambertini, Neel, Dummer, Wagner, Dotto (bib52) 2008; 10 Seroogy, Gall, Lee, Kornblum (bib85) 1995; 670 Dienstmann, Tabernero (bib20) 2010; 11 Brzezniak, Carter, Giaccone (bib10) 2013; 14 Schneider, Yarden (bib83) 2014; 28 Gu, Li, Wei, Lo, Gong, Li, Iwasato, Itohara, Li, Mody (bib38) 2005; 46 Liu, Neufeld (bib64) 2007; 85 Styren, DeKosky, Rogers, Mufson (bib90) 1993; 615 Wong, Cuervo (bib113) 2010; 13 Roskoski Jr. (bib79) 2019; 139 Kim, Laramy, Mohammad, Talele, Fisher, Sarkaria, Elmquist (bib49) 2019; 47 Kushner, Stephenson, Wright (bib55) 1991; 50 Vecchione (10.1124/mol.120.119909_bib103) 2011; 317 Saltz (10.1124/mol.120.119909_bib80) 2006 Goldberg (10.1124/mol.120.119909_bib35) 2005; 4 Lipinski (10.1124/mol.120.119909_bib61) 2015; 23 Overmiller (10.1124/mol.120.119909_bib74) 2016; 7 Dowell (10.1124/mol.120.119909_bib24) 2005 González-Reyes (10.1124/mol.120.119909_bib36) 2017; 10 Yarden (10.1124/mol.120.119909_bib116) 2001; 37 Engelman (10.1124/mol.120.119909_bib28) 2006; 116 Wakatsuki (10.1124/mol.120.119909_bib105) 2015; 211 Liu (10.1124/mol.120.119909_bib62) 2006; 26 Yang (10.1124/mol.120.119909_bib115) 2016; 8 Kahlson (10.1124/mol.120.119909_bib45) 2015; 9 Schneider (10.1124/mol.120.119909_bib83) 2014; 28 Hammoud (10.1124/mol.120.119909_bib39) 2009; 296 Tavassoly (10.1124/mol.120.119909_bib94) 2015 Abjean (10.1124/mol.120.119909_bib1) 2018; 89 Thomas (10.1124/mol.120.119909_bib98) 2004; 30 Laug (10.1124/mol.120.119909_bib56) 2019; 129 Kushner (10.1124/mol.120.119909_bib55) 1991; 50 Messersmith (10.1124/mol.120.119909_bib68) 2008; 359 Li (10.1124/mol.120.119909_bib60) 2011; 58 Neumann (10.1124/mol.120.119909_bib72) 2004; 107 Tan (10.1124/mol.120.119909_bib92) 2015; 11 Chen (10.1124/mol.120.119909_bib14) 2017; 3 Dorvash (10.1124/mol.120.119909_bib22) 2019; 483 Kolev (10.1124/mol.120.119909_bib52) 2008; 10 Avraham (10.1124/mol.120.119909_bib4) 2011; 12 Kobayashi (10.1124/mol.120.119909_bib51) 2005; 65 Yang (10.1124/mol.120.119909_bib114) 2011; 119 Noro (10.1124/mol.120.119909_bib73) 2006; 6 Yu (10.1124/mol.120.119909_bib118) 2007; 67 Dhaunsi (10.1124/mol.120.119909_bib19) 2016; 15 Schreiber (10.1124/mol.120.119909_bib84) 1986; 232 Bandopadhyay (10.1124/mol.120.119909_bib5) 2004; 127 Duffy (10.1124/mol.120.119909_bib25) 2018; 15 Erschbamer (10.1124/mol.120.119909_bib30) 2007; 27 Kornblum (10.1124/mol.120.119909_bib54) 1997; 380 Lohmann (10.1124/mol.120.119909_bib66) 2019; 138 Birecree (10.1124/mol.120.119909_bib7) 1988; 47 Galvez-Contreras (10.1124/mol.120.119909_bib34) 2013; 7 Iwakura (10.1124/mol.120.119909_bib42) 2005; 93 Kim (10.1124/mol.120.119909_bib48) 2015; 33 Liu (10.1124/mol.120.119909_bib63) 2004; 46 Söllvander (10.1124/mol.120.119909_bib88) 2016; 11 Wang (10.1124/mol.120.119909_bib106) 2017; 114 El-Rayes (10.1124/mol.120.119909_bib27) 2004; 91 Spencer (10.1124/mol.120.119909_bib89) 2019; 53 Liu (10.1124/mol.120.119909_bib65) 2019; 10 Liu (10.1124/mol.120.119909_bib64) 2007; 85 Han (10.1124/mol.120.119909_bib122) 2011; 6 Kim (10.1124/mol.120.119909_bib49) 2019; 47 Chen (10.1124/mol.120.119909_bib15) 2018; 24 Moy (10.1124/mol.120.119909_bib70) 2007 Tavassoly (10.1124/mol.120.119909_bib97) 2015; 4 Ciardiello (10.1124/mol.120.119909_bib18) 2008; 358 Wang (10.1124/mol.120.119909_bib108) 2013; 4 Carpenter (10.1124/mol.120.119909_bib11) 1990; 265 Wang (10.1124/mol.120.119909_bib110) 2012; 7 Greulich (10.1124/mol.120.119909_bib37) 2005; 2 Sato (10.1124/mol.120.119909_bib81) 2019; 79 Lupo (10.1124/mol.120.119909_bib67) 2019; 13 Bose (10.1124/mol.120.119909_bib9) 2009; 18 Morizawa (10.1124/mol.120.119909_bib69) 2017; 8 Tyson (10.1124/mol.120.119909_bib102) 2011; 11 Zhang (10.1124/mol.120.119909_bib119) 2016; 36 Chiang (10.1124/mol.120.119909_bib16) 2010; 107 Tavassoly (10.1124/mol.120.119909_bib96) 2019; 13 Wei (10.1124/mol.120.119909_bib111) 2016; 21 Tripathi (10.1124/mol.120.119909_bib101) 2017; 9 Dienstmann (10.1124/mol.120.119909_bib20) 2010; 11 Raab (10.1124/mol.120.119909_bib78) 1997; 1333 Joe (10.1124/mol.120.119909_bib44) 2018; 27 Dorvash (10.1124/mol.120.119909_bib23) 2020; 12 Brzezniak (10.1124/mol.120.119909_bib10) 2013; 14 Zhang (10.1124/mol.120.119909_bib120) 2005; 46 Ahluwalia (10.1124/mol.120.119909_bib2) 2018; 23 Enwere (10.1124/mol.120.119909_bib29) 2004; 24 Hanahan (10.1124/mol.120.119909_bib40) 2011; 144 Wakatsuki (10.1124/mol.120.119909_bib104) 2016; 9 Ceyzériat (10.1124/mol.120.119909_bib12) 2018; 6 Seroogy (10.1124/mol.120.119909_bib85) 1995; 670 Takeda (10.1124/mol.120.119909_bib91) 2019; 20 Le Pichon (10.1124/mol.120.119909_bib58) 2013; 8 Muhsin (10.1124/mol.120.119909_bib71) 2003 Tremblay (10.1124/mol.120.119909_bib100) 2019; 14 Diniz (10.1124/mol.120.119909_bib21) 2019; 150 Koprich (10.1124/mol.120.119909_bib53) 2008; 5 Kjell (10.1124/mol.120.119909_bib50) 2014; 52 Styren (10.1124/mol.120.119909_bib90) 1993; 615 Fung (10.1124/mol.120.119909_bib123) 2012 Schilsky (10.1124/mol.120.119909_bib82) 2010; 9 Herbst (10.1124/mol.120.119909_bib41) 2004; 59 Forman (10.1124/mol.120.119909_bib32) 2005; 25 Roskoski Jr. (10.1124/mol.120.119909_bib79) 2019; 139 Li (10.1124/mol.120.119909_bib59) 2014; 11 Tan (10.1124/mol.120.119909_bib93) 2017; 8 Pike (10.1124/mol.120.119909_bib76) 1994; 63 Berasain (10.1124/mol.120.119909_bib6) 2014; 28 Perez-Nievas (10.1124/mol.120.119909_bib75) 2018; 10 Wang (10.1124/mol.120.119909_bib107) 2012; 109 Karachaliou (10.1124/mol.120.119909_bib46) 2018; 8 Toyoda (10.1124/mol.120.119909_bib99) 1995; 270 Ciardiello (10.1124/mol.120.119909_bib17) 2004; 16 Yu (10.1124/mol.120.119909_bib117) 2013; 10 Qu (10.1124/mol.120.119909_bib77) 2012; 9 Booth (10.1124/mol.120.119909_bib8) 2017; 40 Chavarría (10.1124/mol.120.119909_bib13) 2018; 475 Frost (10.1124/mol.120.119909_bib33) 2017; 7 Sigismund (10.1124/mol.120.119909_bib87) 2018; 12 Tavassoly (10.1124/mol.120.119909_bib95) 2018; 62 Wang (10.1124/mol.120.119909_bib109) 2016; 27 Wei (10.1124/mol.120.119909_bib112) 2013; 154 Gu (10.1124/mol.120.119909_bib38) 2005; 46 Dunbar (10.1124/mol.120.119909_bib26) 2000; 32 Wong (10.1124/mol.120.119909_bib113) 2010; 13 Ahn (10.1124/mol.120.119909_bib3) 2016; 34 Kaser (10.1124/mol.120.119909_bib47) 1992; 16 Leboulleux (10.1124/mol.120.119909_bib57) 2012; 13 Faideau (10.1124/mol.120.119909_bib31) 2010; 19 Jo (10.1124/mol.120.119909_bib43) 2014; 20 Shandra (10.1124/mol.120.119909_bib86) 2019; 39 |
| References_xml | – volume: 8 year: 2016 ident: bib115 article-title: AZD3759, a BBB-penetrating EGFR inhibitor for the treatment of EGFR mutant NSCLC with CNS metastases publication-title: Sci Transl Med – volume: 9 start-page: 178 year: 2012 ident: bib77 article-title: Inhibition of EGFR/MAPK signaling reduces microglial inflammatory response and the associated secondary damage in rats after spinal cord injury publication-title: J Neuroinflammation – volume: 79 start-page: 6084 year: 2019 end-page: 6100 ident: bib81 article-title: Epigenomic profiling discovers trans-lineage SOX2 partnerships driving tumor heterogeneity in lung squamous cell carcinoma publication-title: Cancer Res – volume: 11 start-page: 38 year: 2016 ident: bib88 article-title: Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons publication-title: Mol Neurodegener – volume: 40 start-page: 358 year: 2017 end-page: 370 ident: bib8 article-title: The role of astrocyte dysfunction in Parkinson’s disease pathogenesis publication-title: Trends Neurosci – volume: 28 start-page: 57 year: 2014 end-page: 61 ident: bib83 article-title: Structure and function of epigen, the last EGFR ligand publication-title: Semin Cell Dev Biol – year: 2006 ident: bib80 publication-title: Panitumumab – volume: 615 start-page: 181 year: 1993 end-page: 190 ident: bib90 article-title: Epidermal growth factor receptor expression in demented elderly: localization to vascular endothelial cells of brain, pituitary and skin publication-title: Brain Res – volume: 6 start-page: 277 year: 2006 ident: bib73 article-title: Gefitinib (IRESSA) sensitive lung cancer cell lines show phosphorylation of Akt without ligand stimulation publication-title: BMC Cancer – volume: 59 start-page: S21 year: 2004 end-page: S26 ident: bib41 article-title: Review of epidermal growth factor receptor biology publication-title: Int J Radiat Oncol Biol Phys – volume: 8 year: 2013 ident: bib58 article-title: EGFR inhibitor erlotinib delays disease progression but does not extend survival in the SOD1 mouse model of ALS publication-title: PLoS One – volume: 1333 start-page: F179 year: 1997 end-page: F199 ident: bib78 article-title: Heparin-binding EGF-like growth factor publication-title: Biochimica Biophysica Acta – volume: 47 start-page: 549 year: 1988 end-page: 560 ident: bib7 article-title: Immunoreactive epidermal growth factor receptors in neuritic plaques from patients with Alzheimer’s disease publication-title: J Neuropathol Exp Neurol – volume: 39 start-page: 1944 year: 2019 end-page: 1963 ident: bib86 article-title: Repetitive diffuse mild traumatic brain injury causes an atypical astrocyte response and spontaneous recurrent seizures publication-title: J Neurosci – volume: 25 start-page: 3539 year: 2005 end-page: 3550 ident: bib32 article-title: Transgenic mouse model of tau pathology in astrocytes leading to nervous system degeneration publication-title: J Neurosci – volume: 4 start-page: S10 year: 2005 end-page: S11 ident: bib35 article-title: Cetuximab publication-title: Nat Rev Drug Discov – volume: 10 start-page: 114 year: 2018 ident: bib75 article-title: Deciphering the astrocyte reaction in Alzheimer’s disease publication-title: Front Aging Neurosci – volume: 358 start-page: 1160 year: 2008 end-page: 1174 ident: bib18 article-title: EGFR antagonists in cancer treatment publication-title: N Engl J Med – volume: 30 start-page: 255 year: 2004 end-page: 268 ident: bib98 article-title: Pharmacokinetic and pharmacodynamic properties of EGFR inhibitors under clinical investigation publication-title: Cancer Treat Rev – volume: 14 start-page: 247 year: 2013 end-page: 253 ident: bib10 article-title: Dacomitinib, a new therapy for the treatment of non-small cell lung cancer publication-title: Expert Opin Pharmacother – volume: 9 year: 2016 ident: bib104 article-title: NADPH oxidases promote apoptosis by activating ZNRF1 ubiquitin ligase in neurons treated with an exogenously applied oxidant publication-title: Commun Integr Biol – volume: 10 start-page: 902 year: 2008 end-page: 911 ident: bib52 article-title: EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer publication-title: Nat Cell Biol – volume: 8 start-page: S23 year: 2018 end-page: S47 ident: bib46 article-title: EGFR first-and second-generation TKIs—there is still place for them in EGFR-mutant NSCLC patients publication-title: Transl Cancer Res – volume: 63 start-page: 517 year: 1994 end-page: 531 ident: bib76 article-title: β-amyloid-induced changes in cultured astrocytes parallel reactive astrocytosis associated with senile plaques in Alzheimer’s disease publication-title: Neuroscience – volume: 28 start-page: 31 year: 2014 end-page: 41 ident: bib6 article-title: Amphiregulin publication-title: Semin Cell Dev Biol – volume: 150 start-page: 138 year: 2019 end-page: 157 ident: bib21 article-title: α-synuclein oligomers enhance astrocyte-induced synapse formation through TGF-β1 signaling in a Parkinson’s disease model publication-title: J Neurochem – volume: 11 start-page: 523 year: 2011 end-page: 532 ident: bib102 article-title: Dynamic modelling of oestrogen signalling and cell fate in breast cancer cells publication-title: Nat Rev Cancer – volume: 9 start-page: 667 year: 2017 end-page: 680 ident: bib101 article-title: Reactive astrocytes promote ALS-like degeneration and intracellular protein aggregation in human motor neurons by disrupting autophagy through TGF-β1 publication-title: Stem Cell Reports – year: 2007 ident: bib70 publication-title: Lapatinib – volume: 138 start-page: 515 year: 2019 end-page: 533 ident: bib66 article-title: Oral and intravenous transmission of α-synuclein fibrils to mice publication-title: Acta Neuropathol – volume: 47 start-page: 393 year: 2019 end-page: 404 ident: bib49 article-title: Brain distribution of a panel of epidermal growth factor receptor inhibitors using cassette dosing in wild-type and Abcb1/Abcg2-deficient mice publication-title: Drug Metab Dispos – volume: 670 start-page: 157 year: 1995 end-page: 164 ident: bib85 article-title: Proliferative zones of postnatal rat brain express epidermal growth factor receptor mRNA publication-title: Brain Res – volume: 9 start-page: 363 year: 2010 end-page: 366 ident: bib82 article-title: Personalized medicine in oncology: the future is now publication-title: Nat Rev Drug Discov – volume: 62 start-page: 487 year: 2018 end-page: 500 ident: bib95 article-title: Systems biology primer: the basic methods and approaches publication-title: Essays Biochem – year: 2015 ident: bib94 publication-title: Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells: Mathematical Modeling and Experimental Observations – volume: 27 start-page: 2631 year: 2016 end-page: 2644 ident: bib109 article-title: Inhibition of EGF receptor blocks the development and progression of peritoneal fibrosis publication-title: J Am Soc Nephrol – volume: 7 year: 2012 ident: bib110 article-title: Oxygen-glucose deprivation induced glial scar-like change in astrocytes publication-title: PLoS One – volume: 144 start-page: 646 year: 2011 end-page: 674 ident: bib40 article-title: Hallmarks of cancer: the next generation publication-title: Cell – volume: 46 start-page: 153 year: 2004 end-page: 168 ident: bib63 article-title: Activation of epidermal growth factor receptor causes astrocytes to form cribriform structures publication-title: Glia – volume: 265 start-page: 7709 year: 1990 end-page: 7712 ident: bib11 article-title: Epidermal growth factor publication-title: J Biol Chem – volume: 32 start-page: 805 year: 2000 end-page: 815 ident: bib26 article-title: Structure-function and biological role of betacellulin publication-title: Int J Biochem Cell Biol – volume: 296 start-page: C735 year: 2009 end-page: C745 ident: bib39 article-title: Tissue inhibitor of metalloproteinase-3 inhibits neonatal mouse cardiomyocyte proliferation via EGFR/JNK/SP-1 signaling publication-title: Am J Physiol Cell Physiol – volume: 232 start-page: 1250 year: 1986 end-page: 1253 ident: bib84 article-title: Transforming growth factor-alpha: a more potent angiogenic mediator than epidermal growth factor publication-title: Science – volume: 9 start-page: 43 year: 2015 end-page: 50 ident: bib45 article-title: Glial tau pathology in tauopathies: functional consequences publication-title: J Exp Neurosci – volume: 7 year: 2017 ident: bib33 article-title: The role of astrocytes in amyloid production and Alzheimer’s disease publication-title: Open Biol – volume: 36 start-page: 1169 year: 2016 end-page: 1178 ident: bib119 article-title: Inhibition of epidermal growth factor receptor improves myelination and attenuates tissue damage of spinal cord injury publication-title: Cell Mol Neurobiol – year: 2005 ident: bib24 publication-title: Erlotinib Hydrochloride – volume: 58 start-page: 812 year: 2011 end-page: 819 ident: bib60 article-title: Inhibiting epidermal growth factor receptor attenuates reactive astrogliosis and improves functional outcome after spinal cord injury in rats publication-title: Neurochem Int – volume: 317 start-page: 2765 year: 2011 end-page: 2771 ident: bib103 article-title: EGFR-targeted therapy publication-title: Exp Cell Res – volume: 13 start-page: 1725 year: 2019 end-page: 1743 ident: bib96 article-title: Genomic signatures defining responsiveness to allopurinol and combination therapy for lung cancer identified by systems therapeutics analyses publication-title: Mol Oncol – volume: 127 start-page: 420 year: 2004 end-page: 430 ident: bib5 article-title: The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson’s disease publication-title: Brain – volume: 33 start-page: 8016 year: 2015 ident: bib48 article-title: AZD3759, an EGFR inhibitor with blood brain barrier (BBB) penetration for the treatment of non-small cell lung cancer (NSCLC) with brain metastasis (BM): preclinical evidence and clinical cases publication-title: J Clin Oncol – volume: 18 start-page: 1735 year: 2009 end-page: 1751 ident: bib9 article-title: Neratinib: an oral, irreversible dual EGFR/HER2 inhibitor for breast and non-small cell lung cancer publication-title: Expert Opin Investig Drugs – volume: 53 start-page: 621 year: 2019 end-page: 626 ident: bib89 article-title: Brigatinib: novel ALK inhibitor for non-small-cell lung cancer publication-title: Ann Pharmacother – volume: 26 start-page: 7532 year: 2006 end-page: 7540 ident: bib62 article-title: Epidermal growth factor receptor activation: an upstream signal for transition of quiescent astrocytes into reactive astrocytes after neural injury publication-title: J Neurosci – volume: 7 start-page: 37536 year: 2016 end-page: 37555 ident: bib74 article-title: c-Src/Cav1-dependent activation of the EGFR by Dsg2 publication-title: Oncotarget – volume: 10 start-page: 551 year: 2013 end-page: 552 ident: bib117 article-title: Targeted therapies: afatinib--new therapy option for EGFR-mutant lung cancer publication-title: Nat Rev Clin Oncol – year: 2012 ident: bib123 article-title: EGFR tyrosine kinase inhibition induces autophagy in cancer cells publication-title: Cancer biology & therapy – volume: 14 start-page: 16 year: 2019 ident: bib100 article-title: Glial phagocytic clearance in Parkinson’s disease publication-title: Mol Neurodegener – volume: 114 start-page: E3129 year: 2017 end-page: E3138 ident: bib106 article-title: ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer’s disease publication-title: Proc Natl Acad Sci USA – volume: 16 start-page: 130 year: 2004 end-page: 135 ident: bib17 article-title: The role of EGFR inhibitors in nonsmall cell lung cancer publication-title: Curr Opin Oncol – volume: 119 start-page: 644 year: 2011 end-page: 653 ident: bib114 article-title: Blocking epidermal growth factor receptor attenuates reactive astrogliosis through inhibiting cell cycle progression and protects against ischemic brain injury in rats publication-title: J Neurochem – volume: 65 start-page: 7096 year: 2005 end-page: 7101 ident: bib51 article-title: An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor publication-title: Cancer Res – volume: 8 start-page: 98771 year: 2017 end-page: 98781 ident: bib93 article-title: Tyrosine kinase inhibitors show different anti-brain metastases efficacy in NSCLC: a direct comparative analysis of icotinib, gefitinib, and erlotinib in a nude mouse model publication-title: Oncotarget – volume: 23 start-page: 565 year: 2015 end-page: 577 ident: bib61 article-title: Function and mechanisms of autophagy in brain and spinal cord trauma publication-title: Antioxid Redox Signal – volume: 24 start-page: 5035 year: 2018 end-page: 5040 ident: bib15 article-title: The impact of EGFR gene polymorphisms on the risk of Alzheimer’s disease in a Chinese han population: a case-controlled study publication-title: Med Sci Monit – volume: 15 start-page: 129 year: 2018 ident: bib25 article-title: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration publication-title: J Neuroinflammation – volume: 20 year: 2019 ident: bib91 article-title: First- and second-generation EGFR-TKIs are all replaced to osimertinib in chemo-naive EGFR mutation-positive non-small cell lung cancer? publication-title: Int J Mol Sci – volume: 211 start-page: 881 year: 2015 end-page: 896 ident: bib105 article-title: Oxidative stress-dependent phosphorylation activates ZNRF1 to induce neuronal/axonal degeneration publication-title: J Cell Biol – volume: 4 start-page: 647 year: 2013 end-page: 649 ident: bib108 article-title: Reduced EGFR level potentially mediates the Aβ42-induced neuronal loss in transgenic fruit fly and mouse publication-title: Protein Cell – volume: 67 start-page: 10417 year: 2007 end-page: 10427 ident: bib118 article-title: Resistance to an irreversible epidermal growth factor receptor (EGFR) inhibitor in EGFR-mutant lung cancer reveals novel treatment strategies publication-title: Cancer Res – volume: 12 start-page: 3 year: 2018 end-page: 20 ident: bib87 article-title: Emerging functions of the EGFR in cancer publication-title: Mol Oncol – volume: 483 year: 2019 ident: bib22 article-title: Dynamic modeling of signal transduction by mTOR complexes in cancer publication-title: J Theor Biol – volume: 93 start-page: 974 year: 2005 end-page: 983 ident: bib42 article-title: Influences of dopaminergic lesion on epidermal growth factor-ErbB signals in Parkinson’s disease and its model: neurotrophic implication in nigrostriatal neurons publication-title: J Neurochem – volume: 19 start-page: 3053 year: 2010 end-page: 3067 ident: bib31 article-title: In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington’s disease subjects publication-title: Hum Mol Genet – volume: 12 start-page: 104 year: 2011 end-page: 117 ident: bib4 article-title: Feedback regulation of EGFR signalling: decision making by early and delayed loops publication-title: Nat Rev Mol Cell Biol – volume: 116 start-page: 2695 year: 2006 end-page: 2706 ident: bib28 article-title: Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer publication-title: J Clin Invest – year: 2003 ident: bib71 publication-title: Gefitinib – volume: 10 start-page: 792 year: 2019 ident: bib65 article-title: TTB protects astrocytes against oxygen-glucose deprivation/reoxygenation-induced injury publication-title: Front Pharmacol – volume: 359 start-page: 1834 year: 2008 end-page: 1836 ident: bib68 article-title: Targeting EGFR in colorectal cancer publication-title: N Engl J Med – volume: 16 start-page: 316 year: 1992 end-page: 322 ident: bib47 article-title: Comparison between epidermal growth factor, transforming growth factor-α and EGF receptor levels in regions of adult rat brain publication-title: Brain Res Mol Brain Res – volume: 11 start-page: 71 year: 2014 ident: bib59 article-title: Epidermal growth factor receptor inhibitor ameliorates excessive astrogliosis and improves the regeneration microenvironment and functional recovery in adult rats following spinal cord injury publication-title: J Neuroinflammation – volume: 11 start-page: 385 year: 2015 end-page: 397 ident: bib92 article-title: Icotinib, a selective EGF receptor tyrosine kinase inhibitor, for the treatment of non-small-cell lung cancer publication-title: Future Oncol – volume: 270 start-page: 7495 year: 1995 end-page: 7500 ident: bib99 article-title: Epiregulin. A novel epidermal growth factor with mitogenic activity for rat primary hepatocytes publication-title: J Biol Chem – volume: 129 start-page: 4408 year: 2019 end-page: 4418 ident: bib56 article-title: Nuclear factor I-A regulates diverse reactive astrocyte responses after CNS injury publication-title: J Clin Invest – volume: 23 start-page: 1199 year: 2018 end-page: 1209 ident: bib2 article-title: Epidermal growth factor receptor tyrosine kinase inhibitors for central nervous system metastases from non-small cell lung cancer publication-title: Oncologist – volume: 52 start-page: 186 year: 2014 end-page: 190 ident: bib50 article-title: Oral erlotinib, but not rapamycin, causes modest acceleration of bladder and hindlimb recovery from spinal cord injury in rats publication-title: Spinal Cord – volume: 6 start-page: 6 year: 2011 ident: bib122 article-title: EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells publication-title: PloS one – volume: 50 start-page: 263 year: 1991 end-page: 277 ident: bib55 article-title: Reactive astrogliosis is widespread in the subcortical white matter of amyotrophic lateral sclerosis brain publication-title: J Neuropathol Exp Neurol – volume: 8 start-page: 28 year: 2017 ident: bib69 article-title: Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway publication-title: Nat Commun – volume: 11 start-page: 1434 year: 2010 end-page: 1441 ident: bib20 article-title: Necitumumab, a fully human IgG1 mAb directed against the EGFR for the potential treatment of cancer publication-title: Curr Opin Investig Drugs – volume: 7 start-page: 258 year: 2013 ident: bib34 article-title: The role of EGFR and ErbB family related proteins in the oligodendrocyte specification in germinal niches of the adult mammalian brain publication-title: Front Cell Neurosci – volume: 46 start-page: 433 year: 2005 end-page: 444 ident: bib38 article-title: Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice publication-title: Neuron – volume: 5 start-page: 8 year: 2008 ident: bib53 article-title: Neuroinflammation mediated by IL-1β increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson’s disease publication-title: J Neuroinflammation – volume: 13 year: 2019 ident: bib67 article-title: Molecular mechanisms of neurogenic aging in the adult mouse subventricular zone publication-title: J Exp Neurosci – volume: 107 start-page: 7060 year: 2010 end-page: 7065 ident: bib16 article-title: PI3 kinase signaling is involved in Abeta-induced memory loss in Drosophila publication-title: Proc Natl Acad Sci USA – volume: 107 start-page: 489 year: 2004 end-page: 496 ident: bib72 article-title: Pathological properties of the Parkinson’s disease-associated protein DJ-1 in α-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick’s disease publication-title: Acta Neuropathol – volume: 13 start-page: 805 year: 2010 end-page: 811 ident: bib113 article-title: Autophagy gone awry in neurodegenerative diseases publication-title: Nat Neurosci – volume: 12 start-page: 1 year: 2020 end-page: 11 ident: bib23 article-title: A systems biology roadmap to decode mTOR control system in cancer publication-title: Interdiscip Sci – volume: 20 start-page: 886 year: 2014 end-page: 896 ident: bib43 article-title: GABA from reactive astrocytes impairs memory in mouse models of Alzheimer’s disease publication-title: Nat Med – volume: 27 start-page: 77 year: 2018 end-page: 87 ident: bib44 article-title: Astrocytes, microglia, and Parkinson’s disease publication-title: Exp Neurobiol – volume: 380 start-page: 243 year: 1997 end-page: 261 ident: bib54 article-title: Prenatal ontogeny of the epidermal growth factor receptor and its ligand, transforming growth factor alpha, in the rat brain publication-title: J Comp Neurol – volume: 89 start-page: A15 year: 2018 ident: bib1 article-title: A42 Reactive astrocytes promote proteostasis in huntington’s disease publication-title: J Neurol Neurosurg Psychiatry – volume: 46 start-page: 2035 year: 2005 end-page: 2041 ident: bib120 article-title: Activation of the epidermal growth factor receptor in optic nerve astrocytes leads to early and transient induction of cyclooxygenase-2 publication-title: Invest Ophthalmol Vis Sci – volume: 21 start-page: 1693 year: 2016 ident: bib111 article-title: Design and synthesis of vandetanib derivatives containing nitroimidazole groups as tyrosine kinase inhibitors in normoxia and hypoxia publication-title: Molecules – volume: 15 start-page: 105 year: 2016 ident: bib19 article-title: Phytanic acid activates NADPH oxidase through transactivation of epidermal growth factor receptor in vascular smooth muscle cells publication-title: Lipids Health Dis – volume: 139 start-page: 395 year: 2019 end-page: 411 ident: bib79 article-title: Small molecule inhibitors targeting the EGFR/ErbB family of protein-tyrosine kinases in human cancers publication-title: Pharmacol Res – volume: 34 start-page: 9003 year: 2016 ident: bib3 article-title: Phase I study of AZD3759, a CNS penetrable EGFR inhibitor, for the treatment of non-small-cell lung cancer (NSCLC) with brain metastasis (BM) and leptomeningeal metastasis (LM) publication-title: J Clin Oncol – volume: 37 start-page: S3 year: 2001 end-page: S8 ident: bib116 article-title: The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities publication-title: Eur J Cancer – volume: 3 start-page: 17044 year: 2017 ident: bib14 article-title: A role for ErbB signaling in the induction of reactive astrogliosis publication-title: Cell Discov – volume: 85 start-page: 3523 year: 2007 end-page: 3529 ident: bib64 article-title: Activation of epidermal growth factor receptors in astrocytes: from development to neural injury publication-title: J Neurosci Res – volume: 91 start-page: 418 year: 2004 end-page: 424 ident: bib27 article-title: Targeting the epidermal growth factor receptor publication-title: Br J Cancer – volume: 24 start-page: 8354 year: 2004 end-page: 8365 ident: bib29 article-title: Aging results in reduced epidermal growth factor receptor signaling, diminished olfactory neurogenesis, and deficits in fine olfactory discrimination publication-title: J Neurosci – volume: 10 start-page: 427 year: 2017 ident: bib36 article-title: Involvement of astrocytes in Alzheimer’s disease from a neuroinflammatory and oxidative stress perspective publication-title: Front Mol Neurosci – volume: 6 start-page: 104 year: 2018 ident: bib12 article-title: Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer’s disease publication-title: Acta Neuropathol Commun – volume: 4 start-page: 263 year: 2015 end-page: 272 ident: bib97 article-title: Dynamic modeling of the interaction between autophagy and apoptosis in mammalian cells publication-title: CPT Pharmacometrics Syst Pharmacol – volume: 2 start-page: e313 year: 2005 ident: bib37 article-title: Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants publication-title: PLoS Med – volume: 109 start-page: 16743 year: 2012 end-page: 16748 ident: bib107 article-title: Epidermal growth factor receptor is a preferred target for treating amyloid-β-induced memory loss publication-title: Proc Natl Acad Sci USA – volume: 13 start-page: 897 year: 2012 end-page: 905 ident: bib57 article-title: Vandetanib in locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 2 trial publication-title: Lancet Oncol – volume: 154 start-page: 1269 year: 2013 end-page: 1284 ident: bib112 article-title: EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance publication-title: Cell – volume: 475 start-page: 3153 year: 2018 end-page: 3169 ident: bib13 article-title: Impact of monomeric, oligomeric and fibrillar alpha-synuclein on astrocyte reactivity and toxicity to neurons publication-title: Biochem J – volume: 27 start-page: 6428 year: 2007 end-page: 6435 ident: bib30 article-title: Inhibiting epidermal growth factor receptor improves structural, locomotor, sensory, and bladder recovery from experimental spinal cord injury publication-title: J Neurosci – volume: 4 start-page: 263 year: 2015 ident: 10.1124/mol.120.119909_bib97 article-title: Dynamic modeling of the interaction between autophagy and apoptosis in mammalian cells publication-title: CPT Pharmacometrics Syst Pharmacol doi: 10.1002/psp4.29 – volume: 6 start-page: 277 year: 2006 ident: 10.1124/mol.120.119909_bib73 article-title: Gefitinib (IRESSA) sensitive lung cancer cell lines show phosphorylation of Akt without ligand stimulation publication-title: BMC Cancer doi: 10.1186/1471-2407-6-277 – volume: 8 year: 2016 ident: 10.1124/mol.120.119909_bib115 article-title: AZD3759, a BBB-penetrating EGFR inhibitor for the treatment of EGFR mutant NSCLC with CNS metastases publication-title: Sci Transl Med doi: 10.1126/scitranslmed.aag0976 – volume: 7 year: 2017 ident: 10.1124/mol.120.119909_bib33 article-title: The role of astrocytes in amyloid production and Alzheimer’s disease publication-title: Open Biol doi: 10.1098/rsob.170228 – volume: 265 start-page: 7709 year: 1990 ident: 10.1124/mol.120.119909_bib11 article-title: Epidermal growth factor publication-title: J Biol Chem doi: 10.1016/S0021-9258(19)38983-5 – volume: 4 start-page: 647 year: 2013 ident: 10.1124/mol.120.119909_bib108 article-title: Reduced EGFR level potentially mediates the Aβ42-induced neuronal loss in transgenic fruit fly and mouse publication-title: Protein Cell doi: 10.1007/s13238-013-3043-8 – year: 2015 ident: 10.1124/mol.120.119909_bib94 – volume: 7 start-page: 37536 year: 2016 ident: 10.1124/mol.120.119909_bib74 article-title: c-Src/Cav1-dependent activation of the EGFR by Dsg2 publication-title: Oncotarget doi: 10.18632/oncotarget.7675 – volume: 270 start-page: 7495 year: 1995 ident: 10.1124/mol.120.119909_bib99 article-title: Epiregulin. A novel epidermal growth factor with mitogenic activity for rat primary hepatocytes publication-title: J Biol Chem – volume: 359 start-page: 1834 year: 2008 ident: 10.1124/mol.120.119909_bib68 article-title: Targeting EGFR in colorectal cancer publication-title: N Engl J Med doi: 10.1056/NEJMe0806778 – volume: 127 start-page: 420 year: 2004 ident: 10.1124/mol.120.119909_bib5 article-title: The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson’s disease publication-title: Brain doi: 10.1093/brain/awh054 – volume: 150 start-page: 138 year: 2019 ident: 10.1124/mol.120.119909_bib21 article-title: α-synuclein oligomers enhance astrocyte-induced synapse formation through TGF-β1 signaling in a Parkinson’s disease model publication-title: J Neurochem doi: 10.1111/jnc.14710 – year: 2007 ident: 10.1124/mol.120.119909_bib70 – year: 2006 ident: 10.1124/mol.120.119909_bib80 – year: 2012 ident: 10.1124/mol.120.119909_bib123 article-title: EGFR tyrosine kinase inhibition induces autophagy in cancer cells publication-title: Cancer biology & therapy doi: 10.4161/cbt.22002 – volume: 23 start-page: 565 year: 2015 ident: 10.1124/mol.120.119909_bib61 article-title: Function and mechanisms of autophagy in brain and spinal cord trauma publication-title: Antioxid Redox Signal doi: 10.1089/ars.2015.6306 – volume: 91 start-page: 418 year: 2004 ident: 10.1124/mol.120.119909_bib27 article-title: Targeting the epidermal growth factor receptor publication-title: Br J Cancer doi: 10.1038/sj.bjc.6601921 – volume: 28 start-page: 57 year: 2014 ident: 10.1124/mol.120.119909_bib83 article-title: Structure and function of epigen, the last EGFR ligand publication-title: Semin Cell Dev Biol doi: 10.1016/j.semcdb.2013.12.011 – volume: 46 start-page: 2035 year: 2005 ident: 10.1124/mol.120.119909_bib120 article-title: Activation of the epidermal growth factor receptor in optic nerve astrocytes leads to early and transient induction of cyclooxygenase-2 publication-title: Invest Ophthalmol Vis Sci doi: 10.1167/iovs.04-1473 – volume: 65 start-page: 7096 year: 2005 ident: 10.1124/mol.120.119909_bib51 article-title: An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-05-1346 – volume: 10 start-page: 792 year: 2019 ident: 10.1124/mol.120.119909_bib65 article-title: TTB protects astrocytes against oxygen-glucose deprivation/reoxygenation-induced injury via activation of Nrf2/HO-1 signaling pathway publication-title: Front Pharmacol doi: 10.3389/fphar.2019.00792 – volume: 317 start-page: 2765 year: 2011 ident: 10.1124/mol.120.119909_bib103 article-title: EGFR-targeted therapy publication-title: Exp Cell Res doi: 10.1016/j.yexcr.2011.08.021 – volume: 32 start-page: 805 year: 2000 ident: 10.1124/mol.120.119909_bib26 article-title: Structure-function and biological role of betacellulin publication-title: Int J Biochem Cell Biol doi: 10.1016/S1357-2725(00)00028-5 – volume: 24 start-page: 5035 year: 2018 ident: 10.1124/mol.120.119909_bib15 article-title: The impact of EGFR gene polymorphisms on the risk of Alzheimer’s disease in a Chinese han population: a case-controlled study publication-title: Med Sci Monit doi: 10.12659/MSM.907809 – volume: 50 start-page: 263 year: 1991 ident: 10.1124/mol.120.119909_bib55 article-title: Reactive astrogliosis is widespread in the subcortical white matter of amyotrophic lateral sclerosis brain publication-title: J Neuropathol Exp Neurol doi: 10.1097/00005072-199105000-00008 – volume: 53 start-page: 621 year: 2019 ident: 10.1124/mol.120.119909_bib89 article-title: Brigatinib: novel ALK inhibitor for non-small-cell lung cancer publication-title: Ann Pharmacother doi: 10.1177/1060028018824578 – volume: 9 start-page: 363 year: 2010 ident: 10.1124/mol.120.119909_bib82 article-title: Personalized medicine in oncology: the future is now publication-title: Nat Rev Drug Discov doi: 10.1038/nrd3181 – volume: 107 start-page: 489 year: 2004 ident: 10.1124/mol.120.119909_bib72 article-title: Pathological properties of the Parkinson’s disease-associated protein DJ-1 in α-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick’s disease publication-title: Acta Neuropathol doi: 10.1007/s00401-004-0834-2 – volume: 16 start-page: 130 year: 2004 ident: 10.1124/mol.120.119909_bib17 article-title: The role of EGFR inhibitors in nonsmall cell lung cancer publication-title: Curr Opin Oncol doi: 10.1097/00001622-200403000-00008 – volume: 30 start-page: 255 year: 2004 ident: 10.1124/mol.120.119909_bib98 article-title: Pharmacokinetic and pharmacodynamic properties of EGFR inhibitors under clinical investigation publication-title: Cancer Treat Rev doi: 10.1016/j.ctrv.2003.10.003 – volume: 18 start-page: 1735 year: 2009 ident: 10.1124/mol.120.119909_bib9 article-title: Neratinib: an oral, irreversible dual EGFR/HER2 inhibitor for breast and non-small cell lung cancer publication-title: Expert Opin Investig Drugs doi: 10.1517/13543780903305428 – volume: 116 start-page: 2695 year: 2006 ident: 10.1124/mol.120.119909_bib28 article-title: Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer publication-title: J Clin Invest doi: 10.1172/JCI28656 – volume: 5 start-page: 8 year: 2008 ident: 10.1124/mol.120.119909_bib53 article-title: Neuroinflammation mediated by IL-1β increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson’s disease publication-title: J Neuroinflammation doi: 10.1186/1742-2094-5-8 – volume: 139 start-page: 395 year: 2019 ident: 10.1124/mol.120.119909_bib79 article-title: Small molecule inhibitors targeting the EGFR/ErbB family of protein-tyrosine kinases in human cancers publication-title: Pharmacol Res doi: 10.1016/j.phrs.2018.11.014 – volume: 129 start-page: 4408 year: 2019 ident: 10.1124/mol.120.119909_bib56 article-title: Nuclear factor I-A regulates diverse reactive astrocyte responses after CNS injury publication-title: J Clin Invest doi: 10.1172/JCI127492 – volume: 358 start-page: 1160 year: 2008 ident: 10.1124/mol.120.119909_bib18 article-title: EGFR antagonists in cancer treatment publication-title: N Engl J Med doi: 10.1056/NEJMra0707704 – volume: 11 start-page: 71 year: 2014 ident: 10.1124/mol.120.119909_bib59 article-title: Epidermal growth factor receptor inhibitor ameliorates excessive astrogliosis and improves the regeneration microenvironment and functional recovery in adult rats following spinal cord injury publication-title: J Neuroinflammation doi: 10.1186/1742-2094-11-71 – volume: 296 start-page: C735 year: 2009 ident: 10.1124/mol.120.119909_bib39 article-title: Tissue inhibitor of metalloproteinase-3 inhibits neonatal mouse cardiomyocyte proliferation via EGFR/JNK/SP-1 signaling publication-title: Am J Physiol Cell Physiol doi: 10.1152/ajpcell.00246.2008 – volume: 380 start-page: 243 year: 1997 ident: 10.1124/mol.120.119909_bib54 article-title: Prenatal ontogeny of the epidermal growth factor receptor and its ligand, transforming growth factor alpha, in the rat brain publication-title: J Comp Neurol doi: 10.1002/(SICI)1096-9861(19970407)380:2<243::AID-CNE7>3.0.CO;2-3 – volume: 27 start-page: 6428 year: 2007 ident: 10.1124/mol.120.119909_bib30 article-title: Inhibiting epidermal growth factor receptor improves structural, locomotor, sensory, and bladder recovery from experimental spinal cord injury publication-title: J Neurosci doi: 10.1523/JNEUROSCI.1037-07.2007 – volume: 11 start-page: 523 year: 2011 ident: 10.1124/mol.120.119909_bib102 article-title: Dynamic modelling of oestrogen signalling and cell fate in breast cancer cells publication-title: Nat Rev Cancer doi: 10.1038/nrc3081 – volume: 119 start-page: 644 year: 2011 ident: 10.1124/mol.120.119909_bib114 article-title: Blocking epidermal growth factor receptor attenuates reactive astrogliosis through inhibiting cell cycle progression and protects against ischemic brain injury in rats publication-title: J Neurochem doi: 10.1111/j.1471-4159.2011.07446.x – volume: 28 start-page: 31 year: 2014 ident: 10.1124/mol.120.119909_bib6 article-title: Amphiregulin publication-title: Semin Cell Dev Biol doi: 10.1016/j.semcdb.2014.01.005 – volume: 23 start-page: 1199 year: 2018 ident: 10.1124/mol.120.119909_bib2 article-title: Epidermal growth factor receptor tyrosine kinase inhibitors for central nervous system metastases from non-small cell lung cancer publication-title: Oncologist doi: 10.1634/theoncologist.2017-0572 – volume: 10 start-page: 902 year: 2008 ident: 10.1124/mol.120.119909_bib52 article-title: EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer publication-title: Nat Cell Biol doi: 10.1038/ncb1750 – volume: 10 start-page: 551 year: 2013 ident: 10.1124/mol.120.119909_bib117 article-title: Targeted therapies: afatinib--new therapy option for EGFR-mutant lung cancer publication-title: Nat Rev Clin Oncol doi: 10.1038/nrclinonc.2013.154 – volume: 2 start-page: e313 year: 2005 ident: 10.1124/mol.120.119909_bib37 article-title: Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants publication-title: PLoS Med doi: 10.1371/journal.pmed.0020313 – volume: 107 start-page: 7060 year: 2010 ident: 10.1124/mol.120.119909_bib16 article-title: PI3 kinase signaling is involved in Abeta-induced memory loss in Drosophila publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0909314107 – volume: 79 start-page: 6084 year: 2019 ident: 10.1124/mol.120.119909_bib81 article-title: Epigenomic profiling discovers trans-lineage SOX2 partnerships driving tumor heterogeneity in lung squamous cell carcinoma publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-19-2132 – volume: 20 year: 2019 ident: 10.1124/mol.120.119909_bib91 article-title: First- and second-generation EGFR-TKIs are all replaced to osimertinib in chemo-naive EGFR mutation-positive non-small cell lung cancer? publication-title: Int J Mol Sci doi: 10.3390/ijms20010146 – volume: 15 start-page: 129 year: 2018 ident: 10.1124/mol.120.119909_bib25 article-title: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration publication-title: J Neuroinflammation doi: 10.1186/s12974-018-1171-z – volume: 46 start-page: 433 year: 2005 ident: 10.1124/mol.120.119909_bib38 article-title: Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice publication-title: Neuron doi: 10.1016/j.neuron.2005.03.025 – volume: 47 start-page: 549 year: 1988 ident: 10.1124/mol.120.119909_bib7 article-title: Immunoreactive epidermal growth factor receptors in neuritic plaques from patients with Alzheimer’s disease publication-title: J Neuropathol Exp Neurol doi: 10.1097/00005072-198809000-00006 – year: 2005 ident: 10.1124/mol.120.119909_bib24 – volume: 25 start-page: 3539 year: 2005 ident: 10.1124/mol.120.119909_bib32 article-title: Transgenic mouse model of tau pathology in astrocytes leading to nervous system degeneration publication-title: J Neurosci doi: 10.1523/JNEUROSCI.0081-05.2005 – volume: 36 start-page: 1169 year: 2016 ident: 10.1124/mol.120.119909_bib119 article-title: Inhibition of epidermal growth factor receptor improves myelination and attenuates tissue damage of spinal cord injury publication-title: Cell Mol Neurobiol doi: 10.1007/s10571-015-0313-4 – volume: 114 start-page: E3129 year: 2017 ident: 10.1124/mol.120.119909_bib106 article-title: ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer’s disease publication-title: Proc Natl Acad Sci USA – volume: 8 start-page: 98771 year: 2017 ident: 10.1124/mol.120.119909_bib93 article-title: Tyrosine kinase inhibitors show different anti-brain metastases efficacy in NSCLC: a direct comparative analysis of icotinib, gefitinib, and erlotinib in a nude mouse model publication-title: Oncotarget doi: 10.18632/oncotarget.21936 – volume: 13 year: 2019 ident: 10.1124/mol.120.119909_bib67 article-title: Molecular mechanisms of neurogenic aging in the adult mouse subventricular zone publication-title: J Exp Neurosci doi: 10.1177/1179069519829040 – volume: 1333 start-page: F179 year: 1997 ident: 10.1124/mol.120.119909_bib78 article-title: Heparin-binding EGF-like growth factor publication-title: Biochimica Biophysica Acta – volume: 37 start-page: S3 issue: Suppl 4 year: 2001 ident: 10.1124/mol.120.119909_bib116 article-title: The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities publication-title: Eur J Cancer doi: 10.1016/S0959-8049(01)00230-1 – volume: 615 start-page: 181 year: 1993 ident: 10.1124/mol.120.119909_bib90 article-title: Epidermal growth factor receptor expression in demented elderly: localization to vascular endothelial cells of brain, pituitary and skin publication-title: Brain Res doi: 10.1016/0006-8993(93)90028-L – volume: 67 start-page: 10417 year: 2007 ident: 10.1124/mol.120.119909_bib118 article-title: Resistance to an irreversible epidermal growth factor receptor (EGFR) inhibitor in EGFR-mutant lung cancer reveals novel treatment strategies publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-07-1248 – volume: 8 year: 2013 ident: 10.1124/mol.120.119909_bib58 article-title: EGFR inhibitor erlotinib delays disease progression but does not extend survival in the SOD1 mouse model of ALS publication-title: PLoS One doi: 10.1371/journal.pone.0062342 – volume: 6 start-page: 6 year: 2011 ident: 10.1124/mol.120.119909_bib122 article-title: EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells publication-title: PloS one doi: 10.1371/journal.pone.0018691 – volume: 8 start-page: 28 year: 2017 ident: 10.1124/mol.120.119909_bib69 article-title: Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway publication-title: Nat Commun doi: 10.1038/s41467-017-00037-1 – volume: 232 start-page: 1250 year: 1986 ident: 10.1124/mol.120.119909_bib84 article-title: Transforming growth factor-alpha: a more potent angiogenic mediator than epidermal growth factor publication-title: Science doi: 10.1126/science.2422759 – volume: 39 start-page: 1944 year: 2019 ident: 10.1124/mol.120.119909_bib86 article-title: Repetitive diffuse mild traumatic brain injury causes an atypical astrocyte response and spontaneous recurrent seizures publication-title: J Neurosci doi: 10.1523/JNEUROSCI.1067-18.2018 – volume: 24 start-page: 8354 year: 2004 ident: 10.1124/mol.120.119909_bib29 article-title: Aging results in reduced epidermal growth factor receptor signaling, diminished olfactory neurogenesis, and deficits in fine olfactory discrimination publication-title: J Neurosci doi: 10.1523/JNEUROSCI.2751-04.2004 – volume: 46 start-page: 153 year: 2004 ident: 10.1124/mol.120.119909_bib63 article-title: Activation of epidermal growth factor receptor causes astrocytes to form cribriform structures publication-title: Glia doi: 10.1002/glia.10358 – volume: 85 start-page: 3523 year: 2007 ident: 10.1124/mol.120.119909_bib64 article-title: Activation of epidermal growth factor receptors in astrocytes: from development to neural injury publication-title: J Neurosci Res doi: 10.1002/jnr.21364 – volume: 9 year: 2016 ident: 10.1124/mol.120.119909_bib104 article-title: NADPH oxidases promote apoptosis by activating ZNRF1 ubiquitin ligase in neurons treated with an exogenously applied oxidant publication-title: Commun Integr Biol doi: 10.1080/19420889.2016.1143575 – volume: 47 start-page: 393 year: 2019 ident: 10.1124/mol.120.119909_bib49 article-title: Brain distribution of a panel of epidermal growth factor receptor inhibitors using cassette dosing in wild-type and Abcb1/Abcg2-deficient mice publication-title: Drug Metab Dispos doi: 10.1124/dmd.118.084210 – volume: 89 start-page: A15 issue: Suppl 1 year: 2018 ident: 10.1124/mol.120.119909_bib1 article-title: A42 Reactive astrocytes promote proteostasis in huntington’s disease publication-title: J Neurol Neurosurg Psychiatry – volume: 4 start-page: S10 year: 2005 ident: 10.1124/mol.120.119909_bib35 article-title: Cetuximab publication-title: Nat Rev Drug Discov doi: 10.1038/nrd1728 – volume: 15 start-page: 105 year: 2016 ident: 10.1124/mol.120.119909_bib19 article-title: Phytanic acid activates NADPH oxidase through transactivation of epidermal growth factor receptor in vascular smooth muscle cells publication-title: Lipids Health Dis doi: 10.1186/s12944-016-0273-9 – volume: 11 start-page: 1434 year: 2010 ident: 10.1124/mol.120.119909_bib20 article-title: Necitumumab, a fully human IgG1 mAb directed against the EGFR for the potential treatment of cancer publication-title: Curr Opin Investig Drugs – volume: 13 start-page: 1725 year: 2019 ident: 10.1124/mol.120.119909_bib96 article-title: Genomic signatures defining responsiveness to allopurinol and combination therapy for lung cancer identified by systems therapeutics analyses publication-title: Mol Oncol doi: 10.1002/1878-0261.12521 – volume: 58 start-page: 812 year: 2011 ident: 10.1124/mol.120.119909_bib60 article-title: Inhibiting epidermal growth factor receptor attenuates reactive astrogliosis and improves functional outcome after spinal cord injury in rats publication-title: Neurochem Int doi: 10.1016/j.neuint.2011.03.007 – volume: 12 start-page: 104 year: 2011 ident: 10.1124/mol.120.119909_bib4 article-title: Feedback regulation of EGFR signalling: decision making by early and delayed loops publication-title: Nat Rev Mol Cell Biol doi: 10.1038/nrm3048 – volume: 27 start-page: 77 year: 2018 ident: 10.1124/mol.120.119909_bib44 article-title: Astrocytes, microglia, and Parkinson’s disease publication-title: Exp Neurobiol doi: 10.5607/en.2018.27.2.77 – volume: 211 start-page: 881 year: 2015 ident: 10.1124/mol.120.119909_bib105 article-title: Oxidative stress-dependent phosphorylation activates ZNRF1 to induce neuronal/axonal degeneration publication-title: J Cell Biol doi: 10.1083/jcb.201506102 – volume: 7 start-page: 258 year: 2013 ident: 10.1124/mol.120.119909_bib34 article-title: The role of EGFR and ErbB family related proteins in the oligodendrocyte specification in germinal niches of the adult mammalian brain publication-title: Front Cell Neurosci doi: 10.3389/fncel.2013.00258 – volume: 11 start-page: 385 year: 2015 ident: 10.1124/mol.120.119909_bib92 article-title: Icotinib, a selective EGF receptor tyrosine kinase inhibitor, for the treatment of non-small-cell lung cancer publication-title: Future Oncol doi: 10.2217/fon.14.249 – volume: 9 start-page: 667 year: 2017 ident: 10.1124/mol.120.119909_bib101 article-title: Reactive astrocytes promote ALS-like degeneration and intracellular protein aggregation in human motor neurons by disrupting autophagy through TGF-β1 publication-title: Stem Cell Reports doi: 10.1016/j.stemcr.2017.06.008 – volume: 483 year: 2019 ident: 10.1124/mol.120.119909_bib22 article-title: Dynamic modeling of signal transduction by mTOR complexes in cancer publication-title: J Theor Biol doi: 10.1016/j.jtbi.2019.109992 – volume: 670 start-page: 157 year: 1995 ident: 10.1124/mol.120.119909_bib85 article-title: Proliferative zones of postnatal rat brain express epidermal growth factor receptor mRNA publication-title: Brain Res doi: 10.1016/0006-8993(94)01300-7 – volume: 52 start-page: 186 year: 2014 ident: 10.1124/mol.120.119909_bib50 article-title: Oral erlotinib, but not rapamycin, causes modest acceleration of bladder and hindlimb recovery from spinal cord injury in rats publication-title: Spinal Cord doi: 10.1038/sc.2013.166 – volume: 6 start-page: 104 year: 2018 ident: 10.1124/mol.120.119909_bib12 article-title: Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer’s disease publication-title: Acta Neuropathol Commun doi: 10.1186/s40478-018-0606-1 – volume: 144 start-page: 646 year: 2011 ident: 10.1124/mol.120.119909_bib40 article-title: Hallmarks of cancer: the next generation publication-title: Cell doi: 10.1016/j.cell.2011.02.013 – volume: 13 start-page: 805 year: 2010 ident: 10.1124/mol.120.119909_bib113 article-title: Autophagy gone awry in neurodegenerative diseases publication-title: Nat Neurosci doi: 10.1038/nn.2575 – year: 2003 ident: 10.1124/mol.120.119909_bib71 – volume: 7 year: 2012 ident: 10.1124/mol.120.119909_bib110 article-title: Oxygen-glucose deprivation induced glial scar-like change in astrocytes publication-title: PLoS One – volume: 19 start-page: 3053 year: 2010 ident: 10.1124/mol.120.119909_bib31 article-title: In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington’s disease subjects publication-title: Hum Mol Genet doi: 10.1093/hmg/ddq212 – volume: 40 start-page: 358 year: 2017 ident: 10.1124/mol.120.119909_bib8 article-title: The role of astrocyte dysfunction in Parkinson’s disease pathogenesis publication-title: Trends Neurosci doi: 10.1016/j.tins.2017.04.001 – volume: 8 start-page: S23 year: 2018 ident: 10.1124/mol.120.119909_bib46 article-title: EGFR first-and second-generation TKIs—there is still place for them in EGFR-mutant NSCLC patients publication-title: Transl Cancer Res doi: 10.21037/tcr.2018.10.06 – volume: 9 start-page: 43 issue: Suppl 2 year: 2015 ident: 10.1124/mol.120.119909_bib45 article-title: Glial tau pathology in tauopathies: functional consequences publication-title: J Exp Neurosci – volume: 109 start-page: 16743 year: 2012 ident: 10.1124/mol.120.119909_bib107 article-title: Epidermal growth factor receptor is a preferred target for treating amyloid-β-induced memory loss publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1208011109 – volume: 12 start-page: 1 year: 2020 ident: 10.1124/mol.120.119909_bib23 article-title: A systems biology roadmap to decode mTOR control system in cancer publication-title: Interdiscip Sci doi: 10.1007/s12539-019-00347-6 – volume: 62 start-page: 487 year: 2018 ident: 10.1124/mol.120.119909_bib95 article-title: Systems biology primer: the basic methods and approaches publication-title: Essays Biochem doi: 10.1042/EBC20180003 – volume: 14 start-page: 247 year: 2013 ident: 10.1124/mol.120.119909_bib10 article-title: Dacomitinib, a new therapy for the treatment of non-small cell lung cancer publication-title: Expert Opin Pharmacother doi: 10.1517/14656566.2013.758714 – volume: 14 start-page: 16 year: 2019 ident: 10.1124/mol.120.119909_bib100 article-title: Glial phagocytic clearance in Parkinson’s disease publication-title: Mol Neurodegener doi: 10.1186/s13024-019-0314-8 – volume: 63 start-page: 517 year: 1994 ident: 10.1124/mol.120.119909_bib76 article-title: β-amyloid-induced changes in cultured astrocytes parallel reactive astrocytosis associated with senile plaques in Alzheimer’s disease publication-title: Neuroscience doi: 10.1016/0306-4522(94)90547-9 – volume: 10 start-page: 427 year: 2017 ident: 10.1124/mol.120.119909_bib36 article-title: Involvement of astrocytes in Alzheimer’s disease from a neuroinflammatory and oxidative stress perspective publication-title: Front Mol Neurosci doi: 10.3389/fnmol.2017.00427 – volume: 9 start-page: 178 year: 2012 ident: 10.1124/mol.120.119909_bib77 article-title: Inhibition of EGFR/MAPK signaling reduces microglial inflammatory response and the associated secondary damage in rats after spinal cord injury publication-title: J Neuroinflammation doi: 10.1186/1742-2094-9-178 – volume: 34 start-page: 9003 year: 2016 ident: 10.1124/mol.120.119909_bib3 article-title: Phase I study of AZD3759, a CNS penetrable EGFR inhibitor, for the treatment of non-small-cell lung cancer (NSCLC) with brain metastasis (BM) and leptomeningeal metastasis (LM) publication-title: J Clin Oncol doi: 10.1200/JCO.2016.34.15_suppl.9003 – volume: 59 start-page: S21 issue: 2 Suppl year: 2004 ident: 10.1124/mol.120.119909_bib41 article-title: Review of epidermal growth factor receptor biology publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2003.11.041 – volume: 475 start-page: 3153 year: 2018 ident: 10.1124/mol.120.119909_bib13 article-title: Impact of monomeric, oligomeric and fibrillar alpha-synuclein on astrocyte reactivity and toxicity to neurons publication-title: Biochem J doi: 10.1042/BCJ20180297 – volume: 10 start-page: 114 year: 2018 ident: 10.1124/mol.120.119909_bib75 article-title: Deciphering the astrocyte reaction in Alzheimer’s disease publication-title: Front Aging Neurosci doi: 10.3389/fnagi.2018.00114 – volume: 12 start-page: 3 year: 2018 ident: 10.1124/mol.120.119909_bib87 article-title: Emerging functions of the EGFR in cancer publication-title: Mol Oncol doi: 10.1002/1878-0261.12155 – volume: 27 start-page: 2631 year: 2016 ident: 10.1124/mol.120.119909_bib109 article-title: Inhibition of EGF receptor blocks the development and progression of peritoneal fibrosis publication-title: J Am Soc Nephrol doi: 10.1681/ASN.2015030299 – volume: 93 start-page: 974 year: 2005 ident: 10.1124/mol.120.119909_bib42 article-title: Influences of dopaminergic lesion on epidermal growth factor-ErbB signals in Parkinson’s disease and its model: neurotrophic implication in nigrostriatal neurons publication-title: J Neurochem doi: 10.1111/j.1471-4159.2005.03073.x – volume: 33 start-page: 8016 year: 2015 ident: 10.1124/mol.120.119909_bib48 article-title: AZD3759, an EGFR inhibitor with blood brain barrier (BBB) penetration for the treatment of non-small cell lung cancer (NSCLC) with brain metastasis (BM): preclinical evidence and clinical cases publication-title: J Clin Oncol doi: 10.1200/jco.2015.33.15_suppl.8016 – volume: 13 start-page: 897 year: 2012 ident: 10.1124/mol.120.119909_bib57 article-title: Vandetanib in locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 2 trial publication-title: Lancet Oncol doi: 10.1016/S1470-2045(12)70335-2 – volume: 21 start-page: 1693 year: 2016 ident: 10.1124/mol.120.119909_bib111 article-title: Design and synthesis of vandetanib derivatives containing nitroimidazole groups as tyrosine kinase inhibitors in normoxia and hypoxia publication-title: Molecules doi: 10.3390/molecules21121693 – volume: 26 start-page: 7532 year: 2006 ident: 10.1124/mol.120.119909_bib62 article-title: Epidermal growth factor receptor activation: an upstream signal for transition of quiescent astrocytes into reactive astrocytes after neural injury publication-title: J Neurosci doi: 10.1523/JNEUROSCI.1004-06.2006 – volume: 138 start-page: 515 year: 2019 ident: 10.1124/mol.120.119909_bib66 article-title: Oral and intravenous transmission of α-synuclein fibrils to mice publication-title: Acta Neuropathol doi: 10.1007/s00401-019-02037-5 – volume: 154 start-page: 1269 year: 2013 ident: 10.1124/mol.120.119909_bib112 article-title: EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance publication-title: Cell doi: 10.1016/j.cell.2013.08.015 – volume: 16 start-page: 316 year: 1992 ident: 10.1124/mol.120.119909_bib47 article-title: Comparison between epidermal growth factor, transforming growth factor-α and EGF receptor levels in regions of adult rat brain publication-title: Brain Res Mol Brain Res doi: 10.1016/0169-328X(92)90241-3 – volume: 20 start-page: 886 year: 2014 ident: 10.1124/mol.120.119909_bib43 article-title: GABA from reactive astrocytes impairs memory in mouse models of Alzheimer’s disease publication-title: Nat Med doi: 10.1038/nm.3639 – volume: 3 start-page: 17044 year: 2017 ident: 10.1124/mol.120.119909_bib14 article-title: A role for ErbB signaling in the induction of reactive astrogliosis publication-title: Cell Discov doi: 10.1038/celldisc.2017.44 – volume: 11 start-page: 38 year: 2016 ident: 10.1124/mol.120.119909_bib88 article-title: Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons publication-title: Mol Neurodegener doi: 10.1186/s13024-016-0098-z |
| SSID | ssj0014580 |
| Score | 2.509585 |
| SecondaryResourceType | review_article |
| Snippet | Several reports have been published recently demonstrating a beneficial effect of epidermal growth factor receptor (EGFR) inhibitors in improving pathologic... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 13 |
| SubjectTerms | Adult Animals Blood-Brain Barrier - drug effects Brain Injuries - drug therapy Brain Injuries - metabolism Central Nervous System - growth & development Central Nervous System - metabolism Child Drug Repositioning ErbB Receptors - antagonists & inhibitors ErbB Receptors - metabolism Gene Expression Regulation, Developmental Humans Molecular Targeted Therapy Neurodegenerative Diseases - drug therapy Neurodegenerative Diseases - metabolism Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Spinal Cord Injuries - drug therapy Spinal Cord Injuries - metabolism Up-Regulation - drug effects |
| Title | Inhibition of Brain Epidermal Growth Factor Receptor Activation: A Novel Target in Neurodegenerative Diseases and Brain Injuries |
| URI | https://dx.doi.org/10.1124/mol.120.119909 https://www.ncbi.nlm.nih.gov/pubmed/32350120 https://www.proquest.com/docview/2396855410 |
| Volume | 98 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Nb9MwFLfKuHBBfFMGyEhoHLqMOHWcBIlDQRsr0sYkMqm3yE7sbdAm1doOwWl_Os92nBTaSoNDozTyq9P8fvF7tt8HQq-JILlSufJkVCiPin7uxTyCF48JJUUMOlro4OSjY3Z4Sj-PwlGnc73ktbSYi73819q4kv9BFa4BrjpK9h-QbX4ULsA54AtHQBiON8J4WJ5fiAtn833Q1R56-7rkK4y2Y72s9GN-3jswFXW0fSin-mSQu4pmNir9uLqS415qPML16odJ11HIM5OP2joW2U0cm83Z9jIsv-lad7Nl2_bIVdrtTdt82M2KfcqvuH4cBtQvE-dIv3j_lZtKTnAH33Vhp7Xth5OaxPX6BExGnS9rGy_AvDgJR8tjbhKvcMsOoDYwtVbFNmJ5dZAPKCAzqcZ7JNBfQaEmrTpzW_h_abnG99DMegKagXwG8pmVv4VuBzDR0DUwPo0aJyFCw9gGMdX_oU77CfJv_-x_k1mzadpizJf0HrpbzzvwwJLoPurI8gHaObFA_dzFaRuHN9vFO_hkCcKH6LplGq4UNhzADdOwZRq2TMOOabhl2js8wIZn2PIMg_gKz7DjGQae1X04nj1Cpwf76cdDr67d4eWU-HMv5CIRSSGpZElOwUgulFDwKRRTPFGx6qtQ5H0ZceXr4OuwkEVCCi4JiyQHvfMYbZVVKZ8izGJOCsYiEFA0USSmNGJM-ByM3ZDkoos89-izvE5sr-urALxroe6iN037qU3psrElcUhmtUFqDc0MqLhR5pWDPIORWm-_8VJWi1kW9BOmnUKJ30VPLBea_vuB3uAP_Gc3vrdtdKd9256jrfnlQr4A-3guXhoK_wa5ecEB |
| linkProvider | Geneva Foundation for Medical Education and Research |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Inhibition+of+Brain+Epidermal+Growth+Factor+Receptor+Activation%3A+A+Novel+Target+in+Neurodegenerative+Diseases+and+Brain+Injuries&rft.jtitle=Molecular+pharmacology&rft.au=Tavassoly%2C+Omid&rft.au=Sato%2C+Takashi&rft.au=Tavassoly%2C+Iman&rft.date=2020-07-01&rft.issn=0026-895X&rft.volume=98&rft.issue=1&rft.spage=13&rft.epage=22&rft_id=info:doi/10.1124%2Fmol.120.119909&rft.externalDBID=n%2Fa&rft.externalDocID=10_1124_mol_120_119909 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0026-895X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0026-895X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0026-895X&client=summon |