The multifunctional poly(A)-binding protein (PABP) 1 is subject to extensive dynamic post-translational modification, which molecular modelling suggests plays an important role in co-ordinating its activities

• Published in: Biochemical journal Vol. 441; no. 3; p. 803
• Main Authors: Brook, Matthew, McCracken, Lora, Reddington, James P, Lu, Zhi-Liang, Morrice, Nicholas A, Gray, Nicola K
• Format: Journal Article
• Language: English
• Published: England 01.02.2012
• Subjects: Animals; Arginine - metabolism; Cells, Cultured; HeLa Cells; Humans; Kinetics; Methylation; Mice; Models, Molecular; Poly(A)-Binding Protein I - chemistry; Poly(A)-Binding Protein I - genetics; Poly(A)-Binding Protein I - metabolism; Poly(A)-Binding Protein I - physiology; Protein Methyltransferases - metabolism; Protein Methyltransferases - physiology; Protein Processing, Post-Translational - genetics; Protein Processing, Post-Translational - physiology; Structure-Activity Relationship; Tissue Distribution

PABP1 [poly(A)-binding protein 1] is a central regulator of mRNA translation and stability and is required for miRNA (microRNA)-mediated regulation and nonsense-mediated decay. Numerous protein, as well as RNA, interactions underlie its multi-functional nature; however, it is unclear how its differe...