Use of GFR equations to adjust drug doses in an elderly multi-ethnic group—a cautionary tale

• Published in: Nephrology, dialysis, transplantation Vol. 22; no. 10; pp. 2894 - 2899
• Main Authors: Gill, Jagbir, Malyuk, Rhonda, Djurdjev, Ognjenka, Levin, Adeera
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.10.2007; Oxford Publishing Limited (England)
• Subjects: Aged; Aged, 80 and over; Algorithms; Amantadine - administration & dosage; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Asian Continental Ancestry Group; Biological and medical sciences; Blood. Blood coagulation. Reticuloendothelial system; Creatinine - blood; Digoxin - administration & dosage; Drug Administration Schedule; drug dosing; eGFR equations; elderly; Emergency and intensive care: renal failure. Dialysis management; Ethnic Groups; European Continental Ancestry Group; Female; Glomerular Filtration Rate; Humans; Immunomodulators; Intensive care medicine; Kidney - pathology; Kidney Failure, Chronic - drug therapy; Kidney Failure, Chronic - ethnology; Kidney Failure, Chronic - pathology; kidney function; Male; Medical sciences; Models, Theoretical; Pharmacology. Drug treatments; Retrospective Studies; validation; drug dosing; kidney function; eGFR equations; elderly; validation; Human; Kidney disease; Extrarenal dialysis; Urinary system disease; Hemodialysis; Renal failure; Elderly; Ethnic group

Background. Glomerular filtration rate (GFR) is the best index of kidney function. Mathematical estimations of GFR, based on serum creatinine (SCr), are a clinically useful method to follow renal function, but have certain limitations which need to be considered. Convention supports the use of Cockc...