Enhanced mucosal SARS-CoV-2 immunity after heterologous intramuscular mRNA prime/intranasal protein boost vaccination with a combination adjuvant - Laghlali, Gabriel; Wiest, Matthew J.; Karadag, Dilara; Warang, Prajakta; O’Konek, Jessica J.; Chang, Lauren A.; Park, Seok-Chan; Yan, Vivian; Farazuddin, Mohammad; Janczak, Katarzyna W.; García-Sastre, Adolfo; Baker, James R.; et al. (Molecular therapy, 2024)
Keywords: Adjuvants, Immunologic - administration & dosage; Adjuvants, Vaccine - administration & dosage; Administration, Intranasal; Animals; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; COVID-19 - immunology; COVID-19 - prevention & control; COVID-19 Vaccines - administration & dosage; COVID-19 Vaccines - immunology; Female; Humans; Immunity, Mucosal; Immunization, Secondary; Injections, Intramuscular; intranasal vaccination; Mice; mRNA vaccines; mRNA Vaccines - immunology; mucosal adjuvants; mucosal immunization; Original; prime/pull; SARS-Cov-2; SARS-CoV-2 - immunology; Spike Glycoprotein, Coronavirus - genetics; Spike Glycoprotein, Coronavirus - immunology; tissue-resident memory T cells; Vaccination - methods; mucosal immunization; SARS-Cov-2; intranasal vaccination; prime/pull; mRNA vaccines; mucosal adjuvants; tissue-resident memory T cells