Epidermal growth factor receptor (EGFR) as a therapeutic target in rheumatoid arthritis
The epidermal growth factor receptor (EGFR) has an important role in the hyperplastic growth of tumor. Similar to tumor growth, rheumatoid arthritis (RA) synovium is hyperplastic, invasive, and expresses EGFR and its ligands. Activation of EGFR signaling is responsible for synovial fibroblast prolif...
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| Published in | Clinical rheumatology Vol. 32; no. 3; pp. 289 - 292 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Springer-Verlag
01.03.2013
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| Subjects | |
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| Abstract | The epidermal growth factor receptor (EGFR) has an important role in the hyperplastic growth of tumor. Similar to tumor growth, rheumatoid arthritis (RA) synovium is hyperplastic, invasive, and expresses EGFR and its ligands. Activation of EGFR signaling is responsible for synovial fibroblast proliferation in RA. Furthermore, in addition to its role in proliferation, EGFR and its ligands can induce cytokine production of synovial fibroblasts during the pathogenesis of RA. Agents that target EGFR have yielded promising results in animal experiments involving RA, pharmacologic modulations targeting EGFR, or its ligands may give rise to new therapeutic approaches for RA. In this review article, we will discuss the biological features of EGFR and summarize recent advances regarding the role of EGFR in the pathogenesis and treatment of RA. |
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| AbstractList | The epidermal growth factor receptor (EGFR) has an important role in the hyperplastic growth of tumor. Similar to tumor growth, rheumatoid arthritis (RA) synovium is hyperplastic, invasive, and expresses EGFR and its ligands. Activation of EGFR signaling is responsible for synovial fibroblast proliferation in RA. Furthermore, in addition to its role in proliferation, EGFR and its ligands can induce cytokine production of synovial fibroblasts during the pathogenesis of RA. Agents that target EGFR have yielded promising results in animal experiments involving RA, pharmacologic modulations targeting EGFR, or its ligands may give rise to new therapeutic approaches for RA. In this review article, we will discuss the biological features of EGFR and summarize recent advances regarding the role of EGFR in the pathogenesis and treatment of RA. |
| Author | Yuan, Feng-Lai Lu, Wei-Guo Li, Xia Xu, Rui-Sheng Sun, Jun-Ming Jiang, Dong-Lin |
| Author_xml | – sequence: 1 givenname: Feng-Lai surname: Yuan fullname: Yuan, Feng-Lai email: bjjq88@163.com organization: The Third Hospital Affiliated to Nantong University – sequence: 2 givenname: Xia surname: Li fullname: Li, Xia organization: The Third Hospital Affiliated to Nantong University – sequence: 3 givenname: Wei-Guo surname: Lu fullname: Lu, Wei-Guo organization: The Third Hospital Affiliated to Nantong University – sequence: 4 givenname: Jun-Ming surname: Sun fullname: Sun, Jun-Ming organization: The Third Hospital Affiliated to Nantong University – sequence: 5 givenname: Dong-Lin surname: Jiang fullname: Jiang, Dong-Lin organization: The Third Hospital Affiliated to Nantong University – sequence: 6 givenname: Rui-Sheng surname: Xu fullname: Xu, Rui-Sheng organization: The Third Hospital Affiliated to Nantong University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23179003$$D View this record in MEDLINE/PubMed |
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| Keywords | Rheumatoid arthritis Inflammation Epidermal growth factor receptor |
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| Title | Epidermal growth factor receptor (EGFR) as a therapeutic target in rheumatoid arthritis |
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