Homology modeling and phylogenetic relationships of catalases of an opportunistic pathogen Rhizopus oryzae

• Published in: Life sciences (1973) Vol. 91; no. 3-4; pp. 115 - 126
• Main Authors: Linka, Beáta, Szakonyi, Gerda, Petkovits, Tamás, Nagy, László G., Papp, Tamás, Vágvölgyi, Csaba, Benyhe, Sándor, Ötvös, Ferenc
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 21.08.2012
• Subjects: 3D structure; Algorithms; Amino Acid Sequence; amino acids; Animals; Bayes Theorem; Catalase; Catalase - chemistry; Catalase - metabolism; Cattle; Genome; heme; Heme - chemistry; Homology modeling; Humans; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Mutation; pathogens; Phylogenetic relationships; Phylogeny; Protein Conformation; proteins; R. oryzae; Real-Time Polymerase Chain Reaction - methods; Rhizopus - enzymology; Rhizopus - metabolism; Rhizopus oryzae; Sequence Homology, Amino Acid; Time Factors; Phylogenetic relationships; 3D structure; Catalase; R. oryzae; Homology modeling

A homology modeling methodology was developed and used to obtain the 3D structures for four putative catalases of Rhizopus oryzae in order to assess their functionality. Homology models were built using different modeling strategies using non-protein compounds as steric constraints, a symmetry const...