Post-natal muscle growth and protein turnover: a narrative review of current understanding

• Published in: Nutrition research reviews Vol. 37; no. 1; p. 141
• Main Author: Millward, D Joe
• Format: Journal Article
• Language: English
• Published: England 01.06.2024
• Subjects: Animals; Dietary Proteins; Humans; Insulin-Like Growth Factor I - metabolism; Mechanotransduction, Cellular - physiology; Muscle Development - physiology; Muscle Proteins - metabolism; Muscle, Skeletal - metabolism; Rats; Satellite Cells, Skeletal Muscle - metabolism; Satellite Cells, Skeletal Muscle - physiology; Signal Transduction; Signalling pathways; IGF-1; Mechanotransduction; Satellite cells; Myonuclear domain; Protein synthesis
• DOI: 10.1017/s0954422423000124

A model explaining the dietary-protein-driven post-natal skeletal muscle growth and protein turnover in the rat is updated, and the mechanisms involved are described, in this narrative review. Dietary protein controls both bone length and muscle growth, which are interrelated through mechanotransduction mechanisms with muscle growth induced both from stretching subsequent to bone length growth and from internal work against gravity. This induces satellite cell activation, myogenesis and remodelling of the extracellular matrix, establishing a growth capacity for myofibre length and cross-sectional area. Protein deposition within this capacity is enabled by adequate dietary protein and other key nutrients. After briefly reviewing the experimental animal origins of the growth model, key concepts and processes important for growth are reviewed. These include the growth in number and size of the myonuclear domain, satellite cell activity during post-natal development and the autocrine/paracrine action of IGF-1. Regulatory and signalling pathways reviewed include developmental mechanotransduction, signalling through the insulin/IGF-1-PI3K-Akt and the Ras-MAPK pathways in the myofibre and during mechanotransduction of satellite cells. Likely pathways activated by maximal-intensity muscle contractions are highlighted and the regulation of the capacity for protein synthesis in terms of ribosome assembly and the translational regulation of 5-TOPmRNA classes by mTORC1 and LARP1 are discussed. Evidence for and potential mechanisms by which volume limitation of muscle growth can occur which would limit protein deposition within the myofibre are reviewed. An understanding of how muscle growth is achieved allows better nutritional management of its growth in health and disease.