Functional Genomics of the 9p21.3 Locus for Atherosclerosis: Clarity or Confusion?

• Published in: Current cardiology reports Vol. 16; no. 7; p. 502
• Main Authors: Chen, Hsiao-Huei, Almontashiri, Naif A. M., Antoine, Darlène, Stewart, Alexandre F. R.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.07.2014
• Subjects: Atherosclerosis - genetics; Cardiology; Cardiovascular Genomics (R McPherson; Chromosomes, Human, Pair 9 - genetics; Genome-Wide Association Study; Genomics; Humans; Medicine; Medicine & Public Health; Phenotype; Section Editor; Signal Transduction; Topical Collection on Cardiovascular Genomics; Cell proliferation; Enhancers; Atherosclerosis; Macrophages; 9p21.3 CAD risk locus; Vascular smooth muscle cells; Functional genomics

The 9p21.3 locus was the first to yield to genome-wide association studies (GWAS) seeking common genetic variants predisposing to increased risk of coronary artery atherosclerotic disease (CAD). The 59 single nucleotide polymorphisms that show highest association with CAD are clustered in a region 1...