Cell Adhesion Kinase β Forms a Complex with a New Member, Hic-5, of Proteins Localized at Focal Adhesions
Cell adhesion kinase β (CAKβ/PYK2) is the second protein-tyrosine kinase of the focal adhesion kinase subfamily. We identified a cDNA that encodes a CAKβ-binding protein. This cDNA clone encodes the human homologue of Hic-5, the cDNA of which was cloned in 1994 as transforming growth factor β1- and...
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Published in | The Journal of biological chemistry Vol. 273; no. 2; pp. 1003 - 1014 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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United States
Elsevier Inc
09.01.1998
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Abstract | Cell adhesion kinase β (CAKβ/PYK2) is the second protein-tyrosine kinase of the focal adhesion kinase subfamily. We identified a cDNA that encodes a CAKβ-binding protein. This cDNA clone encodes the human homologue of Hic-5, the cDNA of which was cloned in 1994 as transforming growth factor β1- and hydrogen peroxide-inducible mRNA. We found that Hic-5 exclusively localized at focal adhesions in a rat fibroblast line, WFB. This localization of Hic-5 was confirmed in WFB cells expressing Myc-tagged Hic-5. The amino acid sequence of Hic-5 is highly similar to that of paxillin in the four LD motifs as well as in the four contiguous LIM domains.
The Hic-5 N-terminal domain directly associated in vitrowith the extreme C-terminal region (residue 801 to the end) of CAKβ. CAKβ was coimmunoprecipitated with Hic-5 from the WFB cell lysate. The coimmunoprecipitation of CAKβ with Hic-5 was markedly inhibited by the addition of the extreme C-terminal region of CAKβ. Coimmunoprecipitation of Hic-5 with CAKβ, which was shown in COS-7 cells doubly transfected with cDNA constructs of CAKβ and Myc-tagged Hic-5, was lost when the CAKβ amino acid residues 741–903 were deleted. Hic-5 was tyrosine-phosphorylated in Src-transformed 3Y1 cells and in cells treated with pervanadate. Hic-5 associated with CAKβ was selectively tyrosine-phosphorylated in WFB cells exposed to hypertonic osmotic stress. These results indicate that Hic-5 is a paxillin-related component of focal adhesions and binds to CAKβ, implying possible involvement of Hic-5 in the downstream signaling of CAKβ. |
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AbstractList | Cell adhesion kinase β (CAKβ/PYK2) is the second protein-tyrosine kinase of the focal adhesion kinase subfamily. We identified a cDNA that encodes a CAKβ-binding protein. This cDNA clone encodes the human homologue of Hic-5, the cDNA of which was cloned in 1994 as transforming growth factor β1- and hydrogen peroxide-inducible mRNA. We found that Hic-5 exclusively localized at focal adhesions in a rat fibroblast line, WFB. This localization of Hic-5 was confirmed in WFB cells expressing Myc-tagged Hic-5. The amino acid sequence of Hic-5 is highly similar to that of paxillin in the four LD motifs as well as in the four contiguous LIM domains.
The Hic-5 N-terminal domain directly associated in vitrowith the extreme C-terminal region (residue 801 to the end) of CAKβ. CAKβ was coimmunoprecipitated with Hic-5 from the WFB cell lysate. The coimmunoprecipitation of CAKβ with Hic-5 was markedly inhibited by the addition of the extreme C-terminal region of CAKβ. Coimmunoprecipitation of Hic-5 with CAKβ, which was shown in COS-7 cells doubly transfected with cDNA constructs of CAKβ and Myc-tagged Hic-5, was lost when the CAKβ amino acid residues 741–903 were deleted. Hic-5 was tyrosine-phosphorylated in Src-transformed 3Y1 cells and in cells treated with pervanadate. Hic-5 associated with CAKβ was selectively tyrosine-phosphorylated in WFB cells exposed to hypertonic osmotic stress. These results indicate that Hic-5 is a paxillin-related component of focal adhesions and binds to CAKβ, implying possible involvement of Hic-5 in the downstream signaling of CAKβ. Cell adhesion kinase beta (CAK beta /PYK2) is the second protein-tyrosine kinase of the focal adhesion kinase subfamily. We identified a cDNA that encodes a CAK beta -binding protein. This cDNA clone encodes the human homologue of Hic-5, the cDNA of which was cloned in 1994 as transforming growth factor beta 1- and hydrogen peroxide-inducible mRNA. We found that Hic-5 exclusively localized at focal adhesions in a rat fibroblast line, WFB. This localization of Hic-5 was confirmed in WFB cells expressing Myc-tagged Hic-5. The amino acid sequence of Hic-5 is highly similar to that of paxillin in the four LD motifs as well as in the four contiguous LIM domains. The Hic-5 N-terminal domain directly associated in vitro with the extreme C-terminal region (residue 801 to the end) of CAK beta . CAK beta was coimmunoprecipitated with Hic-5 from the WFB cell lysate. The coimmunoprecipitation of CAK beta with Hic-5 was markedly inhibited by the addition of the extreme C-terminal region of CAK beta . Coimmunoprecipitation of Hic-5 with CAK beta , which was shown in COS-7 cells doubly transfected with cDNA constructs of CAK beta and Myc-tagged Hic-5, was lost when the CAK beta amino acid residues 741-903 were deleted. Hic-5 was tyrosine-phosphorylated in Src-transformed 3Y1 cells and in cells treated with pervanadate. Hic-5 associated with CAK beta was selectively tyrosine-phosphorylated in WFB cells exposed to hypertonic osmotic stress. These results indicate that Hic-5 is a paxillin-related component of focal adhesions and binds to CAK beta , implying possible involvement of Hic-5 in the downstream signaling of CAK beta . Cell adhesion kinase beta (CAKbeta/PYK2) is the second protein-tyrosine kinase of the focal adhesion kinase subfamily. We identified a cDNA that encodes a CAKbeta-binding protein. This cDNA clone encodes the human homologue of Hic-5, the cDNA of which was cloned in 1994 as transforming growth factor beta1- and hydrogen peroxide-inducible mRNA. We found that Hic-5 exclusively localized at focal adhesions in a rat fibroblast line, WFB. This localization of Hic-5 was confirmed in WFB cells expressing Myc-tagged Hic-5. The amino acid sequence of Hic-5 is highly similar to that of paxillin in the four LD motifs as well as in the four contiguous LIM domains. The Hic-5 N-terminal domain directly associated in vitro with the extreme C-terminal region (residue 801 to the end) of CAKbeta. CAKbeta was coimmunoprecipitated with Hic-5 from the WFB cell lysate. The coimmunoprecipitation of CAKbeta with Hic-5 was markedly inhibited by the addition of the extreme C-terminal region of CAKbeta. Coimmunoprecipitation of Hic-5 with CAKbeta, which was shown in COS-7 cells doubly transfected with cDNA constructs of CAKbeta and Myc-tagged Hic-5, was lost when the CAKbeta amino acid residues 741-903 were deleted. Hic-5 was tyrosine-phosphorylated in Src-transformed 3Y1 cells and in cells treated with pervanadate. Hic-5 associated with CAKbeta was selectively tyrosine-phosphorylated in WFB cells exposed to hypertonic osmotic stress. These results indicate that Hic-5 is a paxillin-related component of focal adhesions and binds to CAKbeta, implying possible involvement of Hic-5 in the downstream signaling of CAKbeta. |
Author | Matsuya, Manabu Mitaka, Toshihiro Takahashi, Shuji Ishino, Masaho Sasaki, Terukatsu Nagura, Kazuko Sasaki, Hiroko Ohba, Takeaki Suzuki, Rumiko Aoto, Hiroshi |
Author_xml | – sequence: 1 givenname: Manabu surname: Matsuya fullname: Matsuya, Manabu organization: Departments of Biochemistry, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-Ku, Sapporo 060, Japan – sequence: 2 givenname: Hiroko surname: Sasaki fullname: Sasaki, Hiroko organization: Departments of Biochemistry, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-Ku, Sapporo 060, Japan – sequence: 3 givenname: Hiroshi surname: Aoto fullname: Aoto, Hiroshi organization: Departments of Biochemistry, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-Ku, Sapporo 060, Japan – sequence: 4 givenname: Toshihiro surname: Mitaka fullname: Mitaka, Toshihiro organization: Departments of Pathology, Cancer Research Institute, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-Ku, Sapporo 060, Japan – sequence: 5 givenname: Kazuko surname: Nagura fullname: Nagura, Kazuko organization: Departments of Biochemistry, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-Ku, Sapporo 060, Japan – sequence: 6 givenname: Takeaki surname: Ohba fullname: Ohba, Takeaki organization: Departments of Biochemistry, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-Ku, Sapporo 060, Japan – sequence: 7 givenname: Masaho surname: Ishino fullname: Ishino, Masaho organization: Departments of Biochemistry, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-Ku, Sapporo 060, Japan – sequence: 8 givenname: Shuji surname: Takahashi fullname: Takahashi, Shuji organization: Department of Pathology, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-Ku, Sapporo 060, Japan – sequence: 9 givenname: Rumiko surname: Suzuki fullname: Suzuki, Rumiko organization: Departments of Biochemistry, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-Ku, Sapporo 060, Japan – sequence: 10 givenname: Terukatsu surname: Sasaki fullname: Sasaki, Terukatsu email: sasaki@cc.sapmed.ac.jp organization: Departments of Biochemistry, Sapporo Medical University School of Medicine, South-1, West-17, Chuo-Ku, Sapporo 060, Japan |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/9422762$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1016/S0021-9258(18)47085-8 10.1016/0378-1119(88)90005-4 10.1016/0014-4827(75)90532-7 10.1002/ijc.2910150419 10.1074/jbc.270.29.17437 10.1002/jcp.1041360305 10.1073/pnas.89.18.8487 10.1083/jcb.119.4.893 10.1016/0092-8674(94)90191-0 10.1016/0955-0674(94)90097-3 10.1074/jbc.270.36.21206 10.1128/MCB.16.6.3169 10.1128/MCB.13.8.4648 10.1016/0022-2836(73)90198-8 10.1083/jcb.108.2.229 10.1016/S0021-9258(18)82425-5 10.1074/jbc.271.47.29993 10.1074/jbc.272.1.228 10.1074/jbc.270.28.16995 10.1016/0092-8674(92)90108-O 10.1084/jem.182.4.1089 10.1083/jcb.135.4.1109 10.1016/S0022-2836(05)80360-2 10.1126/science.273.5276.792 10.1038/383547a0 10.1128/MCB.14.1.147 10.1016/S0960-9822(95)00060-1 10.1038/372786a0 10.1016/0378-1119(94)00685-L 10.1016/0092-8674(92)90385-P 10.1182/blood.V88.2.417.bloodjournal882417 10.1074/jbc.272.40.25319 10.1074/jbc.270.10.5039 10.1074/jbc.271.27.15934 10.1128/MCB.15.5.2635 10.1038/376737a0 10.1006/geno.1996.0149 10.1128/MCB.17.3.1224 10.1074/jbc.270.46.27742 10.1083/jcb.131.3.791 10.1002/eji.1830270147 10.1007/s004390050249 10.1073/pnas.92.23.10678 10.1074/jbc.271.49.31222 |
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Copyright | 1998 © 1998 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. |
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References | Lev, Moreno, Martinez, Canoll, Peles, Musacchio, Plowman, Rudy, Schlessinger (bib2) 1995; 376 Herzog, Nicholl, Hort, Sutherland, Shine (bib4) 1996; 32 Mayer, Hirai, Sakai (bib29) 1995; 5 Miyamoto, Teramoto, Coso, Gutkind, Burbelo, Akiyama, Yamada (bib17) 1995; 131 Sells, Chernoff (bib26) 1995; 152 Weng, Taylor, Turner, Brugge, Seidel-Dugan (bib46) 1993; 268 Wu, Durick, Songyang, Cantley, Taylor, Gill (bib37) 1996; 271 Yagihashi, Sato, Torigoe, Okubo, Konno, Takahashi, Yamashita, Fujinaga, Kuzumaki, Kikuchi (bib30) 1988; 48 Tachibana, Sato, D'Avirro, Morimoto (bib18) 1995; 182 Schaller, Parsons (bib48) 1995; 15 Hildebrand, Taylor, Parsons (bib15) 1996; 16 Kozak (bib39) 1989; 108 Burridge, Turner, Romer (bib41) 1992; 119 Sasaki, Nagura, Ishino, Ohba, Matsuya, Sasaki (bib6) 1995; 30 Schaller, Parsons (bib8) 1994; 6 Cobb, Schaller, Leu, Parsons (bib9) 1994; 14 Sasaki, Nagura, Ishino, Tobioka, Kotani, Sasaki (bib1) 1995; 270 Dikic, Tokiwa, Lev, Courtneidge, Schlessinger (bib10) 1996; 383 Mitaka, Shindoh, Mochizuki, Sasaki, Ishino, Matsuya, Ninomiya, Sasaki (bib16) 1997; 150 Shibanuma, Mochizuki, Maniwa, Mashimo, Nishiya, Imai, Takano, Oshimura, Nose (bib24) 1997; 17 Michalopoulos, Pitot (bib33) 1975; 94 Dawid, Toyama, Taira (bib42) 1995; 318 Bellis, Miller, Turner (bib49) 1995; 270 Altschul, Gish, Miller, Myers, Lipman (bib35) 1990; 215 Inazawa, Sasaki, Nagura, Kakazu, Abe, Sasaki (bib7) 1996; 98 Ishino, Ohba, Sasaki, Sasaki (bib13) 1995; 11 Li, Avraham, Rogers, Raja, Avraham (bib44) 1996; 88 Schmeichel, Beckerle (bib36) 1994; 79 Schlaepfer, Hanks, Hunter, van der Geer (bib11) 1994; 372 Polte, Hanks (bib12) 1995; 92 Hanks, Calalb, Harper, Patel (bib27) 1992; 89 Tokiwa, Dikic, Lev, Schlessinger (bib22) 1996; 273 Ma, Lou, Berg, Ostergaard (bib45) 1997; 27 Salgia, Li, Lo, Brunkhorst, Kansas, Sobhany, Sun, Pisick, Hallek, Ernst, Tantravahi, Chen, Griffin (bib40) 1995; 270 Chen, Appeddu, Parsons, Hildebrand, Schaller, Guan (bib19) 1995; 270 Tanaka, Zaitsu, Onodera, Kimura (bib31) 1988; 136 Zachary, Rozengurt (bib21) 1992; 71 Brown, Perrotta, Turner (bib38) 1996; 135 Birge, Fajardo, Reichman, Shoelson, Songyang, Cantley, Hanafusa (bib47) 1993; 13 Kimura, Itagaki, Summers (bib32) 1975; 15 Astier, Avraham, Manie, Groopman, Canty, Avraham, Freedman (bib14) 1997; 272 Kaelin, Krek, Sellers, DeCaprio, Ajchenbaum, Fuchs, Chittenden, Li, Farnham, Blanar, Livingston, Flemington (bib25) 1992; 70 Smith, Johnson (bib28) 1988; 67 Yu, Li, Marchetto, Dy, Hunter, Calvo, Dawson, Wilm, Anderegg, Graves, Earp (bib5) 1996; 271 Shibanuma, Mashimo, Kuroki, Nose (bib23) 1994; 269 Laemmli, Favre (bib34) 1973; 80 Schaller, Sasaki (bib43) 1997; 272 Salgia, Avraham, Pisick, Li, Raja, Greenfield, Sattler, Avraham, Griffin (bib20) 1996; 271 Avraham, London, Fu, Ota, Hiregowdara, Li, Jiang, Pasztor, White, Groopman, Avraham (bib3) 1995; 270 Kozak (10.1074/jbc.273.2.1003_bib39) 1989; 108 Laemmli (10.1074/jbc.273.2.1003_bib34) 1973; 80 Avraham (10.1074/jbc.273.2.1003_bib3) 1995; 270 Miyamoto (10.1074/jbc.273.2.1003_bib17) 1995; 131 Schlaepfer (10.1074/jbc.273.2.1003_bib11) 1994; 372 Yagihashi (10.1074/jbc.273.2.1003_bib30) 1988; 48 Lev (10.1074/jbc.273.2.1003_bib2) 1995; 376 Herzog (10.1074/jbc.273.2.1003_bib4) 1996; 32 Shibanuma (10.1074/jbc.273.2.1003_bib24) 1997; 17 Schaller (10.1074/jbc.273.2.1003_bib48) 1995; 15 Schaller (10.1074/jbc.273.2.1003_bib43) 1997; 272 Weng (10.1074/jbc.273.2.1003_bib46) 1993; 268 Salgia (10.1074/jbc.273.2.1003_bib40) 1995; 270 Inazawa (10.1074/jbc.273.2.1003_bib7) 1996; 98 Hildebrand (10.1074/jbc.273.2.1003_bib15) 1996; 16 Tokiwa (10.1074/jbc.273.2.1003_bib22) 1996; 273 Sasaki (10.1074/jbc.273.2.1003_bib1) 1995; 270 Schaller (10.1074/jbc.273.2.1003_bib8) 1994; 6 Mitaka (10.1074/jbc.273.2.1003_bib16) 1997; 150 Yu (10.1074/jbc.273.2.1003_bib5) 1996; 271 Ishino (10.1074/jbc.273.2.1003_bib13) 1995; 11 Shibanuma (10.1074/jbc.273.2.1003_bib23) 1994; 269 Kimura (10.1074/jbc.273.2.1003_bib32) 1975; 15 Brown (10.1074/jbc.273.2.1003_bib38) 1996; 135 Schmeichel (10.1074/jbc.273.2.1003_bib36) 1994; 79 Astier (10.1074/jbc.273.2.1003_bib14) 1997; 272 Wu (10.1074/jbc.273.2.1003_bib37) 1996; 271 Mayer (10.1074/jbc.273.2.1003_bib29) 1995; 5 Cobb (10.1074/jbc.273.2.1003_bib9) 1994; 14 Dawid (10.1074/jbc.273.2.1003_bib42) 1995; 318 Zachary (10.1074/jbc.273.2.1003_bib21) 1992; 71 Tanaka (10.1074/jbc.273.2.1003_bib31) 1988; 136 Kaelin (10.1074/jbc.273.2.1003_bib25) 1992; 70 Dikic (10.1074/jbc.273.2.1003_bib10) 1996; 383 Hanks (10.1074/jbc.273.2.1003_bib27) 1992; 89 Ma (10.1074/jbc.273.2.1003_bib45) 1997; 27 Polte (10.1074/jbc.273.2.1003_bib12) 1995; 92 Michalopoulos (10.1074/jbc.273.2.1003_bib33) 1975; 94 Li (10.1074/jbc.273.2.1003_bib44) 1996; 88 Bellis (10.1074/jbc.273.2.1003_bib49) 1995; 270 Birge (10.1074/jbc.273.2.1003_bib47) 1993; 13 Chen (10.1074/jbc.273.2.1003_bib19) 1995; 270 Salgia (10.1074/jbc.273.2.1003_bib20) 1996; 271 Tachibana (10.1074/jbc.273.2.1003_bib18) 1995; 182 Smith (10.1074/jbc.273.2.1003_bib28) 1988; 67 Burridge (10.1074/jbc.273.2.1003_bib41) 1992; 119 Sasaki (10.1074/jbc.273.2.1003_bib6) 1995; 30 Sells (10.1074/jbc.273.2.1003_bib26) 1995; 152 Altschul (10.1074/jbc.273.2.1003_bib35) 1990; 215 |
References_xml | – volume: 372 start-page: 786 year: 1994 end-page: 791 ident: bib11 publication-title: Nature contributor: fullname: van der Geer – volume: 71 start-page: 891 year: 1992 end-page: 894 ident: bib21 publication-title: Cell contributor: fullname: Rozengurt – volume: 182 start-page: 1089 year: 1995 end-page: 1100 ident: bib18 publication-title: J. Exp. Med. contributor: fullname: Morimoto – volume: 70 start-page: 351 year: 1992 end-page: 364 ident: bib25 publication-title: Cell contributor: fullname: Flemington – volume: 94 start-page: 70 year: 1975 end-page: 78 ident: bib33 publication-title: Exp. Cell Res. contributor: fullname: Pitot – volume: 272 start-page: 25319 year: 1997 end-page: 25325 ident: bib43 publication-title: J. Biol. Chem. contributor: fullname: Sasaki – volume: 270 start-page: 27742 year: 1995 end-page: 27751 ident: bib3 publication-title: J. Biol. Chem. contributor: fullname: Avraham – volume: 16 start-page: 3169 year: 1996 end-page: 3178 ident: bib15 publication-title: Mol. Cell. Biol. contributor: fullname: Parsons – volume: 271 start-page: 15934 year: 1996 end-page: 15941 ident: bib37 publication-title: J. Biol. Chem. contributor: fullname: Gill – volume: 89 start-page: 8487 year: 1992 end-page: 8491 ident: bib27 publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Patel – volume: 271 start-page: 31222 year: 1996 end-page: 31226 ident: bib20 publication-title: J. Biol. Chem. contributor: fullname: Griffin – volume: 152 start-page: 187 year: 1995 end-page: 189 ident: bib26 publication-title: Gene (Amst.) contributor: fullname: Chernoff – volume: 270 start-page: 16995 year: 1995 end-page: 16999 ident: bib19 publication-title: J. Biol. Chem. contributor: fullname: Guan – volume: 268 start-page: 14956 year: 1993 end-page: 14963 ident: bib46 publication-title: J. Biol. Chem. contributor: fullname: Seidel-Dugan – volume: 48 start-page: 2798 year: 1988 end-page: 2804 ident: bib30 publication-title: Cancer Res. contributor: fullname: Kikuchi – volume: 273 start-page: 792 year: 1996 end-page: 794 ident: bib22 publication-title: Science contributor: fullname: Schlessinger – volume: 15 start-page: 2635 year: 1995 end-page: 2645 ident: bib48 publication-title: Mol. Cell. Biol. contributor: fullname: Parsons – volume: 131 start-page: 791 year: 1995 end-page: 805 ident: bib17 publication-title: J. Cell Biol. contributor: fullname: Yamada – volume: 270 start-page: 17437 year: 1995 end-page: 17441 ident: bib49 publication-title: J. Biol. Chem. contributor: fullname: Turner – volume: 92 start-page: 10678 year: 1995 end-page: 10682 ident: bib12 publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Hanks – volume: 30 start-page: 37 year: 1995 end-page: 46 ident: bib6 publication-title: Tumor Res. contributor: fullname: Sasaki – volume: 376 start-page: 737 year: 1995 end-page: 745 ident: bib2 publication-title: Nature contributor: fullname: Schlessinger – volume: 136 start-page: 421 year: 1988 end-page: 430 ident: bib31 publication-title: J. Cell. Physiol. contributor: fullname: Kimura – volume: 383 start-page: 547 year: 1996 end-page: 550 ident: bib10 publication-title: Nature contributor: fullname: Schlessinger – volume: 272 start-page: 228 year: 1997 end-page: 232 ident: bib14 publication-title: J. Biol. Chem. contributor: fullname: Freedman – volume: 98 start-page: 508 year: 1996 end-page: 510 ident: bib7 publication-title: Hum. Genet. contributor: fullname: Sasaki – volume: 108 start-page: 229 year: 1989 end-page: 241 ident: bib39 publication-title: J. Cell Biol. contributor: fullname: Kozak – volume: 270 start-page: 5039 year: 1995 end-page: 5047 ident: bib40 publication-title: J. Biol. Chem. contributor: fullname: Griffin – volume: 79 start-page: 211 year: 1994 end-page: 219 ident: bib36 publication-title: Cell contributor: fullname: Beckerle – volume: 88 start-page: 417 year: 1996 end-page: 428 ident: bib44 publication-title: Blood contributor: fullname: Avraham – volume: 271 start-page: 29993 year: 1996 end-page: 29998 ident: bib5 publication-title: J. Biol. Chem. contributor: fullname: Earp – volume: 318 start-page: 295 year: 1995 end-page: 306 ident: bib42 publication-title: C. R. Acad. Sci. Paris contributor: fullname: Taira – volume: 13 start-page: 4648 year: 1993 end-page: 4656 ident: bib47 publication-title: Mol. Cell. Biol. contributor: fullname: Hanafusa – volume: 6 start-page: 705 year: 1994 end-page: 710 ident: bib8 publication-title: Curr. Opin. Cell Biol. contributor: fullname: Parsons – volume: 17 start-page: 1224 year: 1997 end-page: 1235 ident: bib24 publication-title: Mol. Cell. Biol. contributor: fullname: Nose – volume: 5 start-page: 296 year: 1995 end-page: 305 ident: bib29 publication-title: Curr. Biol. contributor: fullname: Sakai – volume: 269 start-page: 26767 year: 1994 end-page: 26774 ident: bib23 publication-title: J. Biol. Chem. contributor: fullname: Nose – volume: 32 start-page: 484 year: 1996 end-page: 486 ident: bib4 publication-title: Genomics contributor: fullname: Shine – volume: 150 start-page: 267 year: 1997 end-page: 281 ident: bib16 publication-title: Am. J. Pathol. contributor: fullname: Sasaki – volume: 27 start-page: 329 year: 1997 end-page: 335 ident: bib45 publication-title: Eur. J. Immunol. contributor: fullname: Ostergaard – volume: 11 start-page: 2331 year: 1995 end-page: 2338 ident: bib13 publication-title: Oncogene contributor: fullname: Sasaki – volume: 135 start-page: 1109 year: 1996 end-page: 1123 ident: bib38 publication-title: J. Cell Biol. contributor: fullname: Turner – volume: 270 start-page: 21206 year: 1995 end-page: 21219 ident: bib1 publication-title: J. Biol. Chem. contributor: fullname: Sasaki – volume: 119 start-page: 893 year: 1992 end-page: 903 ident: bib41 publication-title: J. Cell Biol. contributor: fullname: Romer – volume: 215 start-page: 403 year: 1990 end-page: 410 ident: bib35 publication-title: J. Mol. Biol. contributor: fullname: Lipman – volume: 67 start-page: 31 year: 1988 end-page: 40 ident: bib28 publication-title: Gene (Amst.) contributor: fullname: Johnson – volume: 14 start-page: 147 year: 1994 end-page: 155 ident: bib9 publication-title: Mol. Cell. Biol. contributor: fullname: Parsons – volume: 80 start-page: 575 year: 1973 end-page: 599 ident: bib34 publication-title: J. Mol. Biol. contributor: fullname: Favre – volume: 15 start-page: 694 year: 1975 end-page: 706 ident: bib32 publication-title: Int. J. Cancer contributor: fullname: Summers – volume: 48 start-page: 2798 year: 1988 ident: 10.1074/jbc.273.2.1003_bib30 publication-title: Cancer Res. contributor: fullname: Yagihashi – volume: 269 start-page: 26767 year: 1994 ident: 10.1074/jbc.273.2.1003_bib23 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)47085-8 contributor: fullname: Shibanuma – volume: 67 start-page: 31 year: 1988 ident: 10.1074/jbc.273.2.1003_bib28 publication-title: Gene (Amst.) doi: 10.1016/0378-1119(88)90005-4 contributor: fullname: Smith – volume: 94 start-page: 70 year: 1975 ident: 10.1074/jbc.273.2.1003_bib33 publication-title: Exp. Cell Res. doi: 10.1016/0014-4827(75)90532-7 contributor: fullname: Michalopoulos – volume: 150 start-page: 267 year: 1997 ident: 10.1074/jbc.273.2.1003_bib16 publication-title: Am. J. Pathol. contributor: fullname: Mitaka – volume: 15 start-page: 694 year: 1975 ident: 10.1074/jbc.273.2.1003_bib32 publication-title: Int. J. Cancer doi: 10.1002/ijc.2910150419 contributor: fullname: Kimura – volume: 270 start-page: 17437 year: 1995 ident: 10.1074/jbc.273.2.1003_bib49 publication-title: J. Biol. Chem. doi: 10.1074/jbc.270.29.17437 contributor: fullname: Bellis – volume: 136 start-page: 421 year: 1988 ident: 10.1074/jbc.273.2.1003_bib31 publication-title: J. Cell. Physiol. doi: 10.1002/jcp.1041360305 contributor: fullname: Tanaka – volume: 89 start-page: 8487 year: 1992 ident: 10.1074/jbc.273.2.1003_bib27 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.89.18.8487 contributor: fullname: Hanks – volume: 119 start-page: 893 year: 1992 ident: 10.1074/jbc.273.2.1003_bib41 publication-title: J. Cell Biol. doi: 10.1083/jcb.119.4.893 contributor: fullname: Burridge – volume: 79 start-page: 211 year: 1994 ident: 10.1074/jbc.273.2.1003_bib36 publication-title: Cell doi: 10.1016/0092-8674(94)90191-0 contributor: fullname: Schmeichel – volume: 6 start-page: 705 year: 1994 ident: 10.1074/jbc.273.2.1003_bib8 publication-title: Curr. Opin. Cell Biol. doi: 10.1016/0955-0674(94)90097-3 contributor: fullname: Schaller – volume: 270 start-page: 21206 year: 1995 ident: 10.1074/jbc.273.2.1003_bib1 publication-title: J. Biol. Chem. doi: 10.1074/jbc.270.36.21206 contributor: fullname: Sasaki – volume: 16 start-page: 3169 year: 1996 ident: 10.1074/jbc.273.2.1003_bib15 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.16.6.3169 contributor: fullname: Hildebrand – volume: 13 start-page: 4648 year: 1993 ident: 10.1074/jbc.273.2.1003_bib47 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.13.8.4648 contributor: fullname: Birge – volume: 318 start-page: 295 year: 1995 ident: 10.1074/jbc.273.2.1003_bib42 publication-title: C. R. Acad. Sci. Paris contributor: fullname: Dawid – volume: 80 start-page: 575 year: 1973 ident: 10.1074/jbc.273.2.1003_bib34 publication-title: J. Mol. Biol. doi: 10.1016/0022-2836(73)90198-8 contributor: fullname: Laemmli – volume: 108 start-page: 229 year: 1989 ident: 10.1074/jbc.273.2.1003_bib39 publication-title: J. Cell Biol. doi: 10.1083/jcb.108.2.229 contributor: fullname: Kozak – volume: 268 start-page: 14956 year: 1993 ident: 10.1074/jbc.273.2.1003_bib46 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)82425-5 contributor: fullname: Weng – volume: 271 start-page: 29993 year: 1996 ident: 10.1074/jbc.273.2.1003_bib5 publication-title: J. Biol. Chem. doi: 10.1074/jbc.271.47.29993 contributor: fullname: Yu – volume: 272 start-page: 228 year: 1997 ident: 10.1074/jbc.273.2.1003_bib14 publication-title: J. Biol. Chem. doi: 10.1074/jbc.272.1.228 contributor: fullname: Astier – volume: 270 start-page: 16995 year: 1995 ident: 10.1074/jbc.273.2.1003_bib19 publication-title: J. Biol. Chem. doi: 10.1074/jbc.270.28.16995 contributor: fullname: Chen – volume: 70 start-page: 351 year: 1992 ident: 10.1074/jbc.273.2.1003_bib25 publication-title: Cell doi: 10.1016/0092-8674(92)90108-O contributor: fullname: Kaelin – volume: 182 start-page: 1089 year: 1995 ident: 10.1074/jbc.273.2.1003_bib18 publication-title: J. Exp. Med. doi: 10.1084/jem.182.4.1089 contributor: fullname: Tachibana – volume: 135 start-page: 1109 year: 1996 ident: 10.1074/jbc.273.2.1003_bib38 publication-title: J. Cell Biol. doi: 10.1083/jcb.135.4.1109 contributor: fullname: Brown – volume: 215 start-page: 403 year: 1990 ident: 10.1074/jbc.273.2.1003_bib35 publication-title: J. Mol. Biol. doi: 10.1016/S0022-2836(05)80360-2 contributor: fullname: Altschul – volume: 11 start-page: 2331 year: 1995 ident: 10.1074/jbc.273.2.1003_bib13 publication-title: Oncogene contributor: fullname: Ishino – volume: 273 start-page: 792 year: 1996 ident: 10.1074/jbc.273.2.1003_bib22 publication-title: Science doi: 10.1126/science.273.5276.792 contributor: fullname: Tokiwa – volume: 383 start-page: 547 year: 1996 ident: 10.1074/jbc.273.2.1003_bib10 publication-title: Nature doi: 10.1038/383547a0 contributor: fullname: Dikic – volume: 14 start-page: 147 year: 1994 ident: 10.1074/jbc.273.2.1003_bib9 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.14.1.147 contributor: fullname: Cobb – volume: 5 start-page: 296 year: 1995 ident: 10.1074/jbc.273.2.1003_bib29 publication-title: Curr. Biol. doi: 10.1016/S0960-9822(95)00060-1 contributor: fullname: Mayer – volume: 30 start-page: 37 year: 1995 ident: 10.1074/jbc.273.2.1003_bib6 publication-title: Tumor Res. contributor: fullname: Sasaki – volume: 372 start-page: 786 year: 1994 ident: 10.1074/jbc.273.2.1003_bib11 publication-title: Nature doi: 10.1038/372786a0 contributor: fullname: Schlaepfer – volume: 152 start-page: 187 year: 1995 ident: 10.1074/jbc.273.2.1003_bib26 publication-title: Gene (Amst.) doi: 10.1016/0378-1119(94)00685-L contributor: fullname: Sells – volume: 71 start-page: 891 year: 1992 ident: 10.1074/jbc.273.2.1003_bib21 publication-title: Cell doi: 10.1016/0092-8674(92)90385-P contributor: fullname: Zachary – volume: 88 start-page: 417 year: 1996 ident: 10.1074/jbc.273.2.1003_bib44 publication-title: Blood doi: 10.1182/blood.V88.2.417.bloodjournal882417 contributor: fullname: Li – volume: 272 start-page: 25319 year: 1997 ident: 10.1074/jbc.273.2.1003_bib43 publication-title: J. Biol. Chem. doi: 10.1074/jbc.272.40.25319 contributor: fullname: Schaller – volume: 270 start-page: 5039 year: 1995 ident: 10.1074/jbc.273.2.1003_bib40 publication-title: J. Biol. Chem. doi: 10.1074/jbc.270.10.5039 contributor: fullname: Salgia – volume: 271 start-page: 15934 year: 1996 ident: 10.1074/jbc.273.2.1003_bib37 publication-title: J. Biol. Chem. doi: 10.1074/jbc.271.27.15934 contributor: fullname: Wu – volume: 15 start-page: 2635 year: 1995 ident: 10.1074/jbc.273.2.1003_bib48 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.15.5.2635 contributor: fullname: Schaller – volume: 376 start-page: 737 year: 1995 ident: 10.1074/jbc.273.2.1003_bib2 publication-title: Nature doi: 10.1038/376737a0 contributor: fullname: Lev – volume: 32 start-page: 484 year: 1996 ident: 10.1074/jbc.273.2.1003_bib4 publication-title: Genomics doi: 10.1006/geno.1996.0149 contributor: fullname: Herzog – volume: 17 start-page: 1224 year: 1997 ident: 10.1074/jbc.273.2.1003_bib24 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.17.3.1224 contributor: fullname: Shibanuma – volume: 270 start-page: 27742 year: 1995 ident: 10.1074/jbc.273.2.1003_bib3 publication-title: J. Biol. Chem. doi: 10.1074/jbc.270.46.27742 contributor: fullname: Avraham – volume: 131 start-page: 791 year: 1995 ident: 10.1074/jbc.273.2.1003_bib17 publication-title: J. Cell Biol. doi: 10.1083/jcb.131.3.791 contributor: fullname: Miyamoto – volume: 27 start-page: 329 year: 1997 ident: 10.1074/jbc.273.2.1003_bib45 publication-title: Eur. J. Immunol. doi: 10.1002/eji.1830270147 contributor: fullname: Ma – volume: 98 start-page: 508 year: 1996 ident: 10.1074/jbc.273.2.1003_bib7 publication-title: Hum. Genet. doi: 10.1007/s004390050249 contributor: fullname: Inazawa – volume: 92 start-page: 10678 year: 1995 ident: 10.1074/jbc.273.2.1003_bib12 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.92.23.10678 contributor: fullname: Polte – volume: 271 start-page: 31222 year: 1996 ident: 10.1074/jbc.273.2.1003_bib20 publication-title: J. Biol. Chem. doi: 10.1074/jbc.271.49.31222 contributor: fullname: Salgia |
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Snippet | Cell adhesion kinase β (CAKβ/PYK2) is the second protein-tyrosine kinase of the focal adhesion kinase subfamily. We identified a cDNA that encodes a... Cell adhesion kinase beta (CAKbeta/PYK2) is the second protein-tyrosine kinase of the focal adhesion kinase subfamily. We identified a cDNA that encodes a... Cell adhesion kinase beta (CAK beta /PYK2) is the second protein-tyrosine kinase of the focal adhesion kinase subfamily. We identified a cDNA that encodes a... |
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SubjectTerms | Amino Acid Sequence Animals Cell Line Child, Preschool Cloning, Molecular COS Cells Cytoskeletal Proteins - chemistry DNA, Complementary DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Female Focal Adhesion Kinase 2 Glutathione Transferase - genetics Humans Intracellular Signaling Peptides and Proteins LIM Domain Proteins Lysophospholipids - pharmacology Molecular Sequence Data Oxidative Stress Paxillin Phosphoproteins - chemistry Precipitin Tests Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Rats Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Sequence Homology, Amino Acid |
Title | Cell Adhesion Kinase β Forms a Complex with a New Member, Hic-5, of Proteins Localized at Focal Adhesions |
URI | https://dx.doi.org/10.1074/jbc.273.2.1003 https://www.ncbi.nlm.nih.gov/pubmed/9422762 https://search.proquest.com/docview/16322388 https://search.proquest.com/docview/79655704 |
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