The administration of nasal drops in the “Kaiteki” position allows for delivery of the drug to the olfactory cleft: a pilot study in healthy subjects

• Published in: European archives of oto-rhino-laryngology Vol. 273; no. 4; pp. 939 - 943
• Main Authors: Mori, Eri, Merkonidis, Christos, Cuevas, Mandy, Gudziol, Volker, Matsuwaki, Yoshinori, Hummel, Thomas
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2016
• Subjects: Administration, Intranasal - methods; Adult; Coloring Agents - administration & dosage; Drug Delivery Systems - methods; Endoscopy - methods; Female; Head and Neck Surgery; Healthy Volunteers; Humans; Male; Medicine; Medicine & Public Health; Nasal Cavity - anatomy & histology; Nasal Cavity - physiology; Nasal Decongestants - administration & dosage; Neurosurgery; Olfaction Disorders - drug therapy; Olfaction Disorders - physiopathology; Olfactory Mucosa - anatomy & histology; Olfactory Mucosa - physiology; Otorhinolaryngology; Patient Positioning - methods; Pharmaceutical Solutions - administration & dosage; Pilot Projects; Research Design; Rhinology; Nasal drop; Position; Olfaction; Smell; Olfactory cleft

Systemic treatment with corticosteroids shows therapeutic effects, few patients benefit from intranasal topical drug application, probably due to limited access of the drug to the olfactory epithelium. The aim of the present study was to investigate how drops distribute within the nasal cavity when...