Berbamine hydrochloride inhibits bovine viral diarrhea virus replication via interfering in late-stage autophagy

• Published in: Virus research Vol. 321; p. 198905
• Main Authors: Wang, Jun, Yang, Guanghui, Zhang, Linlin, Zhang, Jialu, Wang, Jing, Zou, Yunjing, Wang, Jiufeng
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier 01.11.2022
• Subjects: Animals; Antiviral Agents - pharmacology; Antiviral drugs; antiviral properties; Autophagy; Autophagy-Related Proteins - pharmacology; Benzylisoquinolines; Berbamine hydrochloride; Biological Products - pharmacology; Bovine viral diarrhea virus 1; Bovine Virus Diarrhea-Mucosal Disease; BVDV; Cattle; cattle industry; Cell Line; Chloroquine; Diarrhea; Diarrhea Virus 1, Bovine Viral; Diarrhea Viruses, Bovine Viral - genetics; fluorescent antibody technique; Late-stage autophagy; LC3–LAMP1; pathogens; rapamycin; Sirolimus - pharmacology; Virus Replication; viruses; BVDV; LC3–LAMP1; Antiviral drugs; Late-stage autophagy; Berbamine hydrochloride

Bovine viral diarrhea virus (BVDV) is a harmful pathogen that easily causes large-scale infections and huge economic losses to the cattle industry. Berbamine hydrochloride (BBH) is a natural product extracted from berberis and has a wide range of pharmacological effects. However, the antiviral effec...