Mining Database to Identify Aging-Related Molecular Subtype and Prognostic Signature in Lung Adenocarcinoma
Background. Lung cancer is emerging as one of most deadly diseases, and the mortality rate was still high with 5-year overall survival rate less than 20%. Aging is referred as protumorigenic state, and it plays a significant role in cancer development. Methods. Molecular subtype of lung cancer was i...
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Published in | Journal of oncology Vol. 2022; pp. 1 - 16 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
New York
Hindawi
11.10.2022
John Wiley & Sons, Inc Hindawi Limited |
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Abstract | Background. Lung cancer is emerging as one of most deadly diseases, and the mortality rate was still high with 5-year overall survival rate less than 20%. Aging is referred as protumorigenic state, and it plays a significant role in cancer development. Methods. Molecular subtype of lung cancer was identified by consensus cluster analysis. Prognostic signature was constructed using LASSO cox regression analysis. CeRNA network was constructed to explore lncRNA-miRNA-mRNA regulatory axis. Results. A total of 27 differentially expressed aging-related genes (ARGs) were obtained in LUAD. Three clusters of TCGA-LUAD patients with significant difference in prognosis, immune infiltration, chemotherapy, and targeted therapy were identified. We also developed an aging-related prognostic signature that had a better performance in predicting the1-year, 3-year, and 5-year overall survival of LUAD. Further analysis suggested a significant correlation between prognostic signature gene expression and clinical stage, immune infiltration, tumor mutation burden, microsatellite instability, and drug sensitivity. We also identified the lncRNA UCA1/miR-143-3p/CDK1 regulatory axis in LUAD. Conclusion. Our study identified three clusters of TCGA-LUAD patients with significant difference in prognosis, immune infiltration, chemotherapy, and targeted therapy. We also developed an aging-related prognostic signature that had a good performance in the prognosis of LUAD. |
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AbstractList | Background. Lung cancer is emerging as one of most deadly diseases, and the mortality rate was still high with 5-year overall survival rate less than 20%. Aging is referred as protumorigenic state, and it plays a significant role in cancer development. Methods. Molecular subtype of lung cancer was identified by consensus cluster analysis. Prognostic signature was constructed using LASSO cox regression analysis. CeRNA network was constructed to explore lncRNA-miRNA-mRNA regulatory axis. Results. A total of 27 differentially expressed aging-related genes (ARGs) were obtained in LUAD. Three clusters of TCGA-LUAD patients with significant difference in prognosis, immune infiltration, chemotherapy, and targeted therapy were identified. We also developed an aging-related prognostic signature that had a better performance in predicting the1-year, 3-year, and 5-year overall survival of LUAD. Further analysis suggested a significant correlation between prognostic signature gene expression and clinical stage, immune infiltration, tumor mutation burden, microsatellite instability, and drug sensitivity. We also identified the lncRNA UCA1/miR-143-3p/CDK1 regulatory axis in LUAD. Conclusion. Our study identified three clusters of TCGA-LUAD patients with significant difference in prognosis, immune infiltration, chemotherapy, and targeted therapy. We also developed an aging-related prognostic signature that had a good performance in the prognosis of LUAD. BackgroundLung cancer is emerging as one of most deadly diseases, and the mortality rate was still high with 5-year overall survival rate less than 20%. Aging is referred as protumorigenic state, and it plays a significant role in cancer development. MethodsMolecular subtype of lung cancer was identified by consensus cluster analysis. Prognostic signature was constructed using LASSO cox regression analysis. CeRNA network was constructed to explore lncRNA-miRNA-mRNA regulatory axis. ResultsA total of 27 differentially expressed aging-related genes (ARGs) were obtained in LUAD. Three clusters of TCGA-LUAD patients with significant difference in prognosis, immune infiltration, chemotherapy, and targeted therapy were identified. We also developed an aging-related prognostic signature that had a better performance in predicting the1-year, 3-year, and 5-year overall survival of LUAD. Further analysis suggested a significant correlation between prognostic signature gene expression and clinical stage, immune infiltration, tumor mutation burden, microsatellite instability, and drug sensitivity. We also identified the lncRNA UCA1/miR-143-3p/CDK1 regulatory axis in LUAD. ConclusionOur study identified three clusters of TCGA-LUAD patients with significant difference in prognosis, immune infiltration, chemotherapy, and targeted therapy. We also developed an aging-related prognostic signature that had a good performance in the prognosis of LUAD. |
Audience | Academic |
Author | Feng, Caihou Wu, Bomeng Chen, Ying Lin, Wanli Lan, Cong Che, Weibi Zhang, Hai Liang, Hanping |
AuthorAffiliation | Department of Thoracic Surgery, Gaozhou People's Hospital, Gaozhou 525200, China |
AuthorAffiliation_xml | – name: Department of Thoracic Surgery, Gaozhou People's Hospital, Gaozhou 525200, China |
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Cites_doi | 10.1177/0300060519897508 10.2147/CMAR.S200436 10.18632/aging.102828 10.14336/AD.2016.1230 10.1002/cam4.4404 10.1146/annurev-physiol-030212-183653 10.1186/s12938-021-00871-x 10.3389/fcell.2022.770550 10.1038/s41420-021-00557-2 10.3389/fcell.2021.616271 10.3390/ijms22137016 10.1093/nar/gkx1042 10.1016/j.jim.2018.08.005 10.1007/s12094-021-02575-z 10.3389/fcell.2022.942225 10.18632/oncotarget.15596 10.18632/oncotarget.9821 10.1016/j.path.2019.11.002 10.2147/OTT.S221339 10.18632/aging.202589 10.1111/resp.12789 10.1186/s12859-022-04841-5 10.1016/j.bbrc.2018.01.097 10.1111/jcmm.16582 10.3389/fimmu.2022.977338 10.1002/cam4.3240 10.21037/atm.2020.03.194 10.18632/aging.102814 10.1186/gb-2011-12-4-r41 10.3389/fphar.2022.943944 10.18632/aging.203146 10.1016/j.ccm.2019.10.001 |
ContentType | Journal Article |
Copyright | Copyright © 2022 Caihou Feng et al. COPYRIGHT 2022 John Wiley & Sons, Inc. Copyright © 2022 Caihou Feng et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © 2022 Caihou Feng et al. 2022 |
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Snippet | Background. Lung cancer is emerging as one of most deadly diseases, and the mortality rate was still high with 5-year overall survival rate less than 20%.... BackgroundLung cancer is emerging as one of most deadly diseases, and the mortality rate was still high with 5-year overall survival rate less than 20%. Aging... |
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SubjectTerms | Biomarkers Cancer Chemotherapy Development and progression Gene expression Genes Genomics Health aspects Kinases Lung cancer Medical prognosis Mortality Mutation RNA |
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Title | Mining Database to Identify Aging-Related Molecular Subtype and Prognostic Signature in Lung Adenocarcinoma |
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