Endogenous urate production augments plasma antioxidant capacity in healthy lowland subjects exposed to high altitude

• Published in: Chest Vol. 131; no. 5; p. 1473
• Main Authors: Baillie, J Kenneth, Bates, Matthew G D, Thompson, A A Roger, Waring, W Stephen, Partridge, Roland W, Schnopp, Martin F, Simpson, Alistair, Gulliver-Sloan, Fiona, Maxwell, Simon R J, Webb, David J
• Format: Journal Article
• Language: English
• Published: United States 01.05.2007
• Subjects: Adult; Altitude; Antioxidants - metabolism; Antioxidants - physiology; Bolivia; Cohort Studies; F2-Isoprostanes - blood; Female; Humans; Hypoxia - metabolism; Hypoxia - physiopathology; Luminescent Measurements; Male; Oxidative Stress - physiology; Reactive Oxygen Species - metabolism; Uric Acid - blood; Uric Acid - metabolism

Both tissue hypoxia in vitro, and whole-body hypoxia in vivo, have been found to promote the release of reactive oxygen species (ROS) that are potentially damaging to the cardiovascular system. Antioxidant systems protect against oxidative damage by ROS and may exhibit some degree of responsiveness...