Mixing studies in an unbaffled bioreactor using a computational model corroborated with in-situ Raman and imaging analyses

• Published in: Chemical engineering journal advances Vol. 9; p. 100232
• Main Authors: Vivek, Vasudevan, Eka, Fitriani Nur, Chew, Wee
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.03.2022; Elsevier
• Subjects: Bioreactor; Image analyses; Mixing time; Multi-physics computational model; Multivariate chemometrics; Raman spectroscopy; CFD; MRF; Mixing time; BTEM; CAD; Raman spectroscopy; RGB; RoI; Bioreactor; RANS; Image analyses; Multivariate chemometrics; Multi-physics computational model

•Designed a computational model of a non-standard 10 L bioreactor.•Single-phase mixing simulations validated against literature.•Tracer mixing experiments performed at various stirrer speeds & liquid viscosities.•Mixing times calculated from image analyses & inline Raman spectroscopy.•Simula...