CCDC92 deficiency ameliorates podocyte lipotoxicity in diabetic kidney disease

• Published in: Metabolism, clinical and experimental Vol. 150; p. 155724
• Main Authors: Zuo, Fuwen, Wang, Youzhao, Xu, Xinlei, Ding, Ruihao, Tang, Wei, Sun, Yu, Wang, Xiaojie, Zhang, Yan, Wu, Jichao, Xie, Yusheng, Liu, Min, Wang, Ziying, Yi, Fan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2024
• Subjects: CCDC92; Diabetic kidney disease; Lipotoxicity; Podocytes; FFA; MPC; GWAS; PAS; IHC; HFD; DM; PFA; IFN-γ; ISGs; STZ; oxLDL; SNPs; CCDC92; Lipotoxicity; DKD; IF; MS; T2D; DAPI; PPARα; CD2AP; GENC; ND; AAV; Cre; HPC; ABCG1; ESRD; CCDC; Podocytes; NRK-52E; SD; GBM; SREBP2; uPAR; SM; SREBP1; UACR; SMPDL3b; WT; LDLR; Diabetic kidney disease; ABCA1; CE; KO; RMC; TG; PC; WT1; UPLC; PE; STRING; HBSS; HG

Podocyte injury is considered as the most important early event contributing to diabetic kidney disease (DKD). Recent findings provide new insights into the roles of lipids and lipid-modulating proteins as key determinants of podocyte function in health and kidney disease. CCDC92, a novel member of...