Distinguishing seizures in autoimmune limbic encephalitis from mesial temporal lobe epilepsy with hippocampal sclerosis: Clues of a temporal plus network

• Published in: Journal of the neurological sciences Vol. 467; p. 123288
• Main Authors: Morano, Alessandra, Cerulli Irelli, Emanuele, Fortunato, Francesco, Casciato, Sara, Panzini, Chiara, Milano, Chiara, Versace, Salvatore, Orlando, Biagio, Iorio, Raffaele, Tinelli, Emanuele, Ruffolo, Gabriele, Pizzanelli, Chiara, Vogrig, Alberto, Quarato, Pierpaolo, Giallonardo, Anna Teresa, Di Gennaro, Giancarlo, Gambardella, Antonio, Di Bonaventura, Carlo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.12.2024
• Subjects: Adult; Aged; Autoimmune Diseases - complications; Autoimmune Diseases - physiopathology; Autoimmune limbic encephalitis; Diagnosis; Diagnosis, Differential; Electroencephalography; Epilepsy, Temporal Lobe - complications; Epilepsy, Temporal Lobe - diagnosis; Epilepsy, Temporal Lobe - diagnostic imaging; Female; Hippocampal Sclerosis; Hippocampus - diagnostic imaging; Hippocampus - pathology; Humans; Limbic Encephalitis - complications; Limbic Encephalitis - diagnosis; Limbic Encephalitis - diagnostic imaging; Limbic Encephalitis - physiopathology; Magnetic Resonance Imaging; Male; Mesial temporal lobe epilepsy; Middle Aged; Neurology; Peri-sylvian; Retrospective Studies; Sclerosis; Seizures; Seizures - diagnosis; Seizures - etiology; Temporal plus epilepsy; Young Adult; AE; MTLE; AAE; FBDS; LCA; Peri-sylvian; TLE; Mesial temporal lobe epilepsy; Autoimmune limbic encephalitis; HV; Temporal plus epilepsy; TPOJ; SEEG; aBIC; SSW; ALE; Diagnosis; AIC; NTLE; MTLE-HS; Seizures; faciobrachial dystonic seizures; aikake information criterion; temporo-parieto-occipital junction; latent class analysis; autoimmune-associated epilepsy; hyperventilation; neocortical temporal lobe epilepsy; sequential spikes/spikes-and-slow waves/sharp waves; temporal lobe epilepsy; Adjusted baikake information criterion; autoimmune encephalitis; mesial temporal lobe epilepsy with hippocampal sclerosis; stereo-EEG
• ISSN: 0022-510X; 1878-5883; 1878-5883
• DOI: 10.1016/j.jns.2024.123288

Diagnosing autoimmune limbic encephalitis (ALE) in adults with new-onset seizures can be challenging, especially when seizures represent the predominant manifestation and MRI findings are not straightforward. By comparison with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS), this...