Protective Effects of Angiotensin II Type-1 Receptor Blockade With Olmesartan on Spinal Cord Ischemia-Reperfusion Injury: An Experimental Study on Rats
Background Spinal cord injury is a major complication of thoracoabdominal aortic operations. We aimed to investigate neuroprotective role of olmesartan administered to rats before ischemia against ischemia-reperfusion (I-R) injury. Methods Twenty-four Wistar albino rats were randomly divided into th...
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| Published in | Annals of vascular surgery Vol. 24; no. 6; pp. 801 - 808 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Elsevier Inc
01.08.2010
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| Abstract | Background Spinal cord injury is a major complication of thoracoabdominal aortic operations. We aimed to investigate neuroprotective role of olmesartan administered to rats before ischemia against ischemia-reperfusion (I-R) injury. Methods Twenty-four Wistar albino rats were randomly divided into three groups ( n = 8 per group): group I (control group, the sham-operation group), group II (the I-R group undergoing aortic occlusion without pharmacologic treatment), and group III (olmesartan-treated group receiving 3 mg/kg/d olmesartan for 14 days before ischemia). Spinal cord ischemia was induced by infrarenal aortic clamping for 45 minutes, followed by reperfusion. Neurological status was assessed by using modified Tarlov score preoperatively and at 48 hours postoperatively. Spinal cords were harvested for histopathologic examination with hematoxylin-eosin staining and biochemical analysis for tissue malondialdehyde, superoxide dismutase, and glutathione peroxidase levels. Results The rats in the ischemia group had severe deficits including paraplegia after surgery, and they had a worse neurological status compared with the sham group ( p < 0.05). The mean Tarlov scores in the ischemia and olmesartan-treated groups at 48 hours postoperatively were 1.6 ± 0.4 and 2.2 ± 0.9, respectively ( p < 0.05). Histopathologic analyses demonstrated typical changes of ischemic necrosis in the ischemia group; however, olmesartan attenuated tissue necrosis. Decreased spinal cord tissue malondialdehyde ( p = 0.047) and increased tissue superoxide dismutase ( p = 0.001) and glutathione peroxidase ( p = 0.009) levels were measured in the olmesartan-treated group compared with the ischemia group. Conclusion Olmesartan may protect the spinal cord from I-R injury and reduce the incidence of associated neurological dysfunction after temporary aortic occlusion. |
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| AbstractList | BACKGROUNDSpinal cord injury is a major complication of thoracoabdominal aortic operations. We aimed to investigate neuroprotective role of olmesartan administered to rats before ischemia against ischemia-reperfusion (I-R) injury.METHODSTwenty-four Wistar albino rats were randomly divided into three groups (n = 8 per group): group I (control group, the sham-operation group), group II (the I-R group undergoing aortic occlusion without pharmacologic treatment), and group III (olmesartan-treated group receiving 3 mg/kg/d olmesartan for 14 days before ischemia). Spinal cord ischemia was induced by infrarenal aortic clamping for 45 minutes, followed by reperfusion. Neurological status was assessed by using modified Tarlov score preoperatively and at 48 hours postoperatively. Spinal cords were harvested for histopathologic examination with hematoxylin-eosin staining and biochemical analysis for tissue malondialdehyde, superoxide dismutase, and glutathione peroxidase levels.RESULTSThe rats in the ischemia group had severe deficits including paraplegia after surgery, and they had a worse neurological status compared with the sham group (p < 0.05). The mean Tarlov scores in the ischemia and olmesartan-treated groups at 48 hours postoperatively were 1.6 +/- 0.4 and 2.2 +/- 0.9, respectively (p < 0.05). Histopathologic analyses demonstrated typical changes of ischemic necrosis in the ischemia group; however, olmesartan attenuated tissue necrosis. Decreased spinal cord tissue malondialdehyde (p = 0.047) and increased tissue superoxide dismutase (p = 0.001) and glutathione peroxidase (p = 0.009) levels were measured in the olmesartan-treated group compared with the ischemia group.CONCLUSIONOlmesartan may protect the spinal cord from I-R injury and reduce the incidence of associated neurological dysfunction after temporary aortic occlusion. Spinal cord injury is a major complication of thoracoabdominal aortic operations. We aimed to investigate neuroprotective role of olmesartan administered to rats before ischemia against ischemia-reperfusion (I-R) injury. Twenty-four Wistar albino rats were randomly divided into three groups ( n = 8 per group): group I (control group, the sham-operation group), group II (the I-R group undergoing aortic occlusion without pharmacologic treatment), and group III (olmesartan-treated group receiving 3 mg/kg/d olmesartan for 14 days before ischemia). Spinal cord ischemia was induced by infrarenal aortic clamping for 45 minutes, followed by reperfusion. Neurological status was assessed by using modified Tarlov score preoperatively and at 48 hours postoperatively. Spinal cords were harvested for histopathologic examination with hematoxylin-eosin staining and biochemical analysis for tissue malondialdehyde, superoxide dismutase, and glutathione peroxidase levels. The rats in the ischemia group had severe deficits including paraplegia after surgery, and they had a worse neurological status compared with the sham group ( p < 0.05). The mean Tarlov scores in the ischemia and olmesartan-treated groups at 48 hours postoperatively were 1.6 ± 0.4 and 2.2 ± 0.9, respectively ( p < 0.05). Histopathologic analyses demonstrated typical changes of ischemic necrosis in the ischemia group; however, olmesartan attenuated tissue necrosis. Decreased spinal cord tissue malondialdehyde ( p = 0.047) and increased tissue superoxide dismutase ( p = 0.001) and glutathione peroxidase ( p = 0.009) levels were measured in the olmesartan-treated group compared with the ischemia group. Olmesartan may protect the spinal cord from I-R injury and reduce the incidence of associated neurological dysfunction after temporary aortic occlusion. Spinal cord injury is a major complication of thoracoabdominal aortic operations. We aimed to investigate neuroprotective role of olmesartan administered to rats before ischemia against ischemia-reperfusion (I-R) injury. Twenty-four Wistar albino rats were randomly divided into three groups (n = 8 per group): group I (control group, the sham-operation group), group II (the I-R group undergoing aortic occlusion without pharmacologic treatment), and group III (olmesartan-treated group receiving 3 mg/kg/d olmesartan for 14 days before ischemia). Spinal cord ischemia was induced by infrarenal aortic clamping for 45 minutes, followed by reperfusion. Neurological status was assessed by using modified Tarlov score preoperatively and at 48 hours postoperatively. Spinal cords were harvested for histopathologic examination with hematoxylin-eosin staining and biochemical analysis for tissue malondialdehyde, superoxide dismutase, and glutathione peroxidase levels. The rats in the ischemia group had severe deficits including paraplegia after surgery, and they had a worse neurological status compared with the sham group (p < 0.05). The mean Tarlov scores in the ischemia and olmesartan-treated groups at 48 hours postoperatively were 1.6 +/- 0.4 and 2.2 +/- 0.9, respectively (p < 0.05). Histopathologic analyses demonstrated typical changes of ischemic necrosis in the ischemia group; however, olmesartan attenuated tissue necrosis. Decreased spinal cord tissue malondialdehyde (p = 0.047) and increased tissue superoxide dismutase (p = 0.001) and glutathione peroxidase (p = 0.009) levels were measured in the olmesartan-treated group compared with the ischemia group. Olmesartan may protect the spinal cord from I-R injury and reduce the incidence of associated neurological dysfunction after temporary aortic occlusion. Background Spinal cord injury is a major complication of thoracoabdominal aortic operations. We aimed to investigate neuroprotective role of olmesartan administered to rats before ischemia against ischemia-reperfusion (I-R) injury. Methods Twenty-four Wistar albino rats were randomly divided into three groups ( n = 8 per group): group I (control group, the sham-operation group), group II (the I-R group undergoing aortic occlusion without pharmacologic treatment), and group III (olmesartan-treated group receiving 3 mg/kg/d olmesartan for 14 days before ischemia). Spinal cord ischemia was induced by infrarenal aortic clamping for 45 minutes, followed by reperfusion. Neurological status was assessed by using modified Tarlov score preoperatively and at 48 hours postoperatively. Spinal cords were harvested for histopathologic examination with hematoxylin-eosin staining and biochemical analysis for tissue malondialdehyde, superoxide dismutase, and glutathione peroxidase levels. Results The rats in the ischemia group had severe deficits including paraplegia after surgery, and they had a worse neurological status compared with the sham group ( p < 0.05). The mean Tarlov scores in the ischemia and olmesartan-treated groups at 48 hours postoperatively were 1.6 ± 0.4 and 2.2 ± 0.9, respectively ( p < 0.05). Histopathologic analyses demonstrated typical changes of ischemic necrosis in the ischemia group; however, olmesartan attenuated tissue necrosis. Decreased spinal cord tissue malondialdehyde ( p = 0.047) and increased tissue superoxide dismutase ( p = 0.001) and glutathione peroxidase ( p = 0.009) levels were measured in the olmesartan-treated group compared with the ischemia group. Conclusion Olmesartan may protect the spinal cord from I-R injury and reduce the incidence of associated neurological dysfunction after temporary aortic occlusion. |
| Author | Ucak, Alper Uysal, Bülent Şahin, Mehmet Ali Demirklç, Ufuk Tatar, Harun Öztaş, Emin Inan, Kaan Arslan, Sddk Onan, Burak Güler, Adem |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20638619$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_acvfr_2012_07_013 crossref_primary_10_1016_j_nbd_2012_11_008 crossref_primary_10_1248_bpb_b16_00296 crossref_primary_10_1532_HSF98_20101126 crossref_primary_10_1007_s11064_022_03794_8 crossref_primary_10_1093_jnen_nlab084 crossref_primary_10_1016_j_spinee_2019_12_002 crossref_primary_10_17116_neiro20218505141 crossref_primary_10_1016_j_avsg_2011_02_024 crossref_primary_10_3389_fncel_2019_00510 crossref_primary_10_2147_JIR_S319023 crossref_primary_10_1134_S1819712414030052 crossref_primary_10_1016_j_avsg_2016_12_016 |
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| Snippet | Background Spinal cord injury is a major complication of thoracoabdominal aortic operations. We aimed to investigate neuroprotective role of olmesartan... Spinal cord injury is a major complication of thoracoabdominal aortic operations. We aimed to investigate neuroprotective role of olmesartan administered to... BACKGROUNDSpinal cord injury is a major complication of thoracoabdominal aortic operations. We aimed to investigate neuroprotective role of olmesartan... |
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| SubjectTerms | Angiotensin II Type 1 Receptor Blockers - pharmacology Animals Aorta, Abdominal - surgery Constriction Disease Models, Animal Glutathione Peroxidase - metabolism Imidazoles - pharmacology Male Malondialdehyde - metabolism Motor Activity Necrosis Neuroprotective Agents - pharmacology Olmesartan Medoxomil Paraplegia - etiology Paraplegia - prevention & control Rats Rats, Wistar Reperfusion Injury - etiology Reperfusion Injury - pathology Reperfusion Injury - physiopathology Reperfusion Injury - prevention & control Spinal Cord - drug effects Spinal Cord - metabolism Spinal Cord - pathology Spinal Cord - physiopathology Spinal Cord Ischemia - complications Spinal Cord Ischemia - drug therapy Spinal Cord Ischemia - pathology Spinal Cord Ischemia - physiopathology Superoxide Dismutase - metabolism Surgery Tetrazoles - pharmacology Time Factors |
| Title | Protective Effects of Angiotensin II Type-1 Receptor Blockade With Olmesartan on Spinal Cord Ischemia-Reperfusion Injury: An Experimental Study on Rats |
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